Poly (MAH-β-cyclodextrin-co-NIPAAm) hydrogels with drug hosting and thermo/pH-sensitive for controlled drug release

Wang, Yue; Yang, Ning; Wang, Dandan; Yang, He; Chen, Li; Zhao, Yiping

doi:10.1016/j.polymdegradstab.2017.11.023

Cited by 41 publications

(23 citation statements)

References 30 publications

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“…On the other hand, the temperature also influences the swelling ratio of the formed gel that is closely related to the rate of dissolution and erosion. The most common polymers, which are used for the preparation of thermo-responsive systems are N-isopropylacrylamide, acrylamide, acryl acid and poly(ethylene glycol) [38][39][40].…”

Section: Responsive Cyclodextrinsmentioning

confidence: 99%

“…The smart system is able to recognize the changing of the pH and releases the active ingredient [41,42]. On the other hand, the pH of the stomach is also less than the colon pH, so using pH sensitive polymer can help to avoid the harmful effects of low pH [36,38]. The mechanism for cyclodextrins is that, the chargeable cyclodextrin molecule entraps the active pharmaceutical ingredients (API) and the pH changes alters the surface charge.…”

Section: Responsive Cyclodextrinsmentioning

confidence: 99%

See 1 more Smart Citation

Cyclodextrins in Drug Delivery Systems and Their Effects on Biological Barriers

et al. 2019

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Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One of their most important properties, is that their inner cavity is hydrophobic, while their surface is hydrophilic. This enables them for the complex formation with lipophilic molecules. They have several applications in the pharmaceutical field like solubility enhancers or the building blocks of larger drug delivery systems. On the other hand, they have numerous effects on cells or biological barriers. In this review the most important properties of cyclodextrins and cyclodextrin-based drug delivery systems are summarized with special focus on their biological activity.

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Section: Responsive Cyclodextrinsmentioning

confidence: 99%

Section: Responsive Cyclodextrinsmentioning

confidence: 99%

Cyclodextrins in Drug Delivery Systems and Their Effects on Biological Barriers

et al. 2019

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“…Some typical bands of CD (1064, 1659, and 2940 cm −1) remained unaffected in the IR spectrum of MA-β-CD, suggesting that the structure of β-CD remains almost unchanged upon functionalization [52]. In addition, the peaks at 1659 and 1737 cm −1 , due to MA, may be the main evidence of the incorporation of MA in the β-CD backbone [33,[53][54][55][56]. Both 1 H NMR and FTIR spectroscopies revealed β-CD modification with the insertion of MA.…”

Section: Synthesis Of Maleic Acid-β-cyclodextrin (Ma-β-cd)mentioning

confidence: 94%

Uncommon Sorption Mechanism of Aromatic Compounds onto Poly(Vinyl Alcohol)/Chitosan/Maleic Anhydride-β-Cyclodextrin Hydrogels

et al. 2020

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Aromatic hydrocarbons are extensive environmental pollutants occurring in both water and air media, and their removal is a priority effort for a healthy environment. The use of adsorbents is among the several strategies used for the remediation of these compounds. In this paper, we aim the synthesis of an amphiphilic hydrogel with the potential for the simultaneous sorption of a set of monocyclic and polycyclic aromatic hydrocarbons associated with toxicity effects in humans. Thus, we start by the synthesis of a copolymer-based in chitosan and β-cyclodextrin previously functionalized with the maleic anhydride. The presence of β-cyclodextrin will confer the ability to interact with hydrophobic compounds. The resulting material is posteriorly incorporated in a cryogel of poly(vinyl alcohol) matrix. We aim to improve the amphiphilic ability of the hydrogel matrix. The obtained hydrogel was characterized by swelling water kinetics, thermogravimetric analysis, rheological measurements, and scanning electron microscopy. The sorption of aromatic hydrocarbons onto the gel is characterized by pseudo-first-order kinetics and Henry isotherm, suggesting a physisorption mechanism. The results show that the presence of maleic anhydride-β-cyclodextrin and chitosan into hydrogels leads to an increase in the removal efficiency of the aromatic compounds. Additionally, the capacity of this hydrogel for removing these pollutants from a fossil fuel sample has also been tested.

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“…They quickly swell and contract because of natural changes, for example, pH, temperature, magnetic or electric field because of the presence of certain functional groups along the polymeric chain [1]. Imaginative medication conveyance advances in view of insightful hydrogels have extraordinary benefit [2,3]. The pH-responsive hydrogels are considered as an appealing for the controlled release of medications because of their pH responsively moves in various locales of the body in both typical and pathological conditions [4].…”

Section: Introductionmentioning

confidence: 99%

“…The pH-responsive hydrogels are considered as an appealing for the controlled release of medications because of their pH responsively moves in various locales of the body in both typical and pathological conditions [4]. 3 Biopolymers hydrogels provide great applications in pharmaceutical field due to nonpoisonous quality, high biocompatibility and biodegradability [5]. Sodium alginate (SA) is a characteristic polysaccharide of a purified carbohydrate extracted from brown seaweeds by utilizing dilute alkali [6].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of oral drug delivery, a pH – sensitive silver nanocomposite based on sodium alginate extracted from Sargassum asperifolium collected from Jazan coasts, KSA

Mohamed

2019

Preprint

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The pH-sensitive nanocomposite composed of sodium alginate/ Pectin/ Tannic acidsilver SA/Pec/TA-Ag was prepared using microwave irradiation and employed as a carrier for Propranolol drug. Physico-chemical characteristics of the prepared systems using Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Field Emission Scanning Electron Microscope (FESEM), High-Resolution Transmission Electron Microscope (HRTEM), Dynamic light Scattering instrument (DLS), and Energy Dispersive X-Ray Analysis (EDX). The percentage drug release was 96% at pH 7.4 within 420 min. The drug release data was fitted into different kinetic models included zero order, First order, Higuchi and Ritger-Peppas model. The release mechanism is non-Fickian character where it controlled by diffusion and relaxation of polymer chains. It can be concluded that SA/Pec/TA-Ag nanocomposite is candidate for the oral drug carrier specific for intestinal system and has stability against gastric fluid.

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Poly (MAH-β-cyclodextrin-co-NIPAAm) hydrogels with drug hosting and thermo/pH-sensitive for controlled drug release

Cited by 41 publications

References 30 publications

Cyclodextrins in Drug Delivery Systems and Their Effects on Biological Barriers

Cyclodextrins in Drug Delivery Systems and Their Effects on Biological Barriers

Uncommon Sorption Mechanism of Aromatic Compounds onto Poly(Vinyl Alcohol)/Chitosan/Maleic Anhydride-β-Cyclodextrin Hydrogels

Synthesis and characterization of oral drug delivery, a pH – sensitive silver nanocomposite based on sodium alginate extracted from Sargassum asperifolium collected from Jazan coasts, KSA

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