Poly(lactic acid-co-glycolic acid)–poly(ethylene glycol)–poly(lactic acid-co-glycolic acid) thermogel as a novel submucosal cushion for endoscopic submucosal dissection

Yu, Lin; Xu, Wei; Shen, Wen; Cao, Liqin; Liu, Yan; Li, Zhao‐Shen; Ding, Jiandong

doi:10.1016/j.actbio.2013.12.007

Cited by 81 publications

(63 citation statements)

References 51 publications

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“…This unique thermogelling property enables this type of material to act as an injectable medical material: at low temperatures such as room temperature, the aqueous sol is injectable and can mix with drugs; after being injected into the body, it gels rapidly in approximately half a minute to form a drug-releasing matrix in situ if the sol-gel transition temperature T gel is between refrigerator (usually 4°C) and body temperature (37°C) and the precipitation temperature is above the body temperature17. Thus far, the use of these thermogels has been attempted in drug delivery464748, post-operative antiadhesion49 and other biomedical applications50.…”

Section: Discussionmentioning

confidence: 99%

Tumor regression achieved by encapsulating a moderately soluble drug into a polymeric thermogel

Chen

et al. 2014

Sci Rep

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For cancer chemotherapy, a tumor regression without any surgical resection and severe side effects is greatly preferred to merely slowing down the growth of tumors. Here, we report a formulation composed of irinotecan (IRN) and poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA). IRN is a clinically used antitumor drug with active and inactive chemical forms in equilibrium, and the major form at physiological conditions is inactive but still has side effects. The aqueous solution of the PLGA-PEG-PLGA is a sol at room temperature and physically gels at body temperature, forming a thermogel. We successfully mixed this moderately soluble drug into the amphiphilic copolymer aqueous solution for the first time. The mixture was subcutaneously injected into nude mice with xenografted SW620 human colon tumors. Excellent in vivo antitumor efficacy was observed in the group that received the IRN-loaded thermogel. The tumor was significantly regressed after being treated with the IRN/thermogel, and the side effects (blood toxicity and body weight decrease) were very mild. These results might be attributed to the ideal sustained release profile and period of release of the drug from the thermogel and to the significant enhancement of the fraction of the active form of the drug by the thermogel.

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Section: Discussionmentioning

confidence: 99%

Tumor regression achieved by encapsulating a moderately soluble drug into a polymeric thermogel

Chen

et al. 2014

Sci Rep

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“…[16,[32][33][34][35][36]. However, the composition window of PLGA-PEG-PLGA triblock copolymers to form a thermogel is quite narrow [37,38].…”

Section: Introductionmentioning

confidence: 97%

Sustained intravitreal delivery of dexamethasone using an injectable and biodegradable thermogel

et al. 2015

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“…Basic and preclinical applications of injectable in situ-forming hydrogels using various cells, like stem cells, have been developed for the treatment of damaged or diseased tissue. [214][215][216][217] Presently, the clinical use of injectable in situ-forming hydrogels in regenerative medicine is in a nascent stage because most research is still being conducted in animal models for bone and cartilage regeneration and vascular autografts. Although a number of injectable in situ-forming hydrogels are commercially available, research must continue to elucidate the mechanisms of tissue development in these materials and determine which cell type is appropriate for each prospective clinical application.…”

Section: Injectable In Situ-forming Hydrogels As Transplants In Regenmentioning

confidence: 99%

Stimuli-Responsive InjectableIn situ-Forming Hydrogels for Regenerative Medicines

Kim

Kwon

et al. 2015

Polymer Reviews

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Research on injectable in situ-forming hydrogels has been conducted in diverse biomedical applications for a long period. These hydrogels exhibit sol-to-gel phase transition in accordance with the external stimuli such as temperature change. Also, unlike the traditional surgical procedures the hydrogels have the distinct properties of easy management and minimal invasiveness via simple aqueous state injections at target sites. Currently, numerous polymer materials have been reported as potential stimulusinduced in situ-forming hydrogels. In this review, a comprehensive overview of the state-of-the-art of these rapidly developing materials has been outlined. In situ-forming hydrogels formed by electrostatic and hydrophobic interactions as well as their mechanistic characteristics and biomedical applications in regenerative medicine have also been discussed. The review concludes with perspectives on the future of stimulus-induced in situ-forming hydrogels.

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Poly(lactic acid-co-glycolic acid)–poly(ethylene glycol)–poly(lactic acid-co-glycolic acid) thermogel as a novel submucosal cushion for endoscopic submucosal dissection

Cited by 81 publications

References 51 publications

Tumor regression achieved by encapsulating a moderately soluble drug into a polymeric thermogel

Tumor regression achieved by encapsulating a moderately soluble drug into a polymeric thermogel

Sustained intravitreal delivery of dexamethasone using an injectable and biodegradable thermogel

Stimuli-Responsive InjectableIn situ-Forming Hydrogels for Regenerative Medicines

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