Poly-l-lactic acid scaffold incorporated chitosan-coated mesoporous silica nanoparticles as pH-sensitive composite for enhanced osteogenic differentiation of human adipose tissue stem cells by dexamethasone delivery

Daryasari, Mohammad Porgham; Telgerd, Mehdi Dusti; Karami, Mohammad Hossein; Zandi-Karimi, Ali; Javar, Hamid Akbari; Khoobi, Mehdi; Seyedjafari, Ehsan; Birhanu, Gebremariam; Khosravian, Pegah; SadatMahdavi, Fatemeh

doi:10.1080/21691401.2019.1658594

Cited by 44 publications

(28 citation statements)

References 43 publications

(53 reference statements)

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“…Ideally, composite scaffolds are required to have an approximate compressive strength of 100–230 MPa; elastic modulus closer to 7–30 GPa; tensile strength of 50–151 MPa; porosity between 60% and 90%; and an average pore size of >150 μm [ 133 , 134 ]. Besides, smart combination of biodegradable polymers and bioactive ceramics have the ability to control fast autocatalytic degradation effect of acidic end groups resulting from hydrolysis of some polymer chains through buffering the pH of the surrounding solution [ 135 ].…”

Section: Medical Application Of 3d Printingmentioning

confidence: 99%

Three dimensional printed nanostructure biomaterials for bone tissue engineering

Marew

Birhanu

2021

Regenerative Therapy

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The suffering from organ dysfunction due to damaged or diseased tissue/bone has been globally on the rise. Current treatment strategies for non-union bone defects include: the use of autografts, allografts, synthetic grafts and free vascularized fibular grafts. Bone tissue engineering has emerged as an alternative for fracture repair to satisfy the current unmet need of bone grafts and to alleviate the problems associated with autografts and allografts. The technology offers the possibility to induce new functional bone regeneration using synergistic combination of functional biomaterials (scaffolds), cells, and growth factors. Bone scaffolds are typically made of porous biodegradable materials that provide the mechanical support during repair and regeneration of damaged or diseased bone. Significant progress has been made towards scaffold materials for structural support, desired osteogenesis and angiogenesis abilities. Thanks for innovative scaffolds fabrication technologies, bioresorbable scaffolds with controlled porosity and tailored properties are possible today. Despite the presence of different bone scaffold fabrication methods, pore size, shape and interconnectivity have not yet been fully controlled in most of the methods. Moreover, scaffolds with tailored porosity for specific defects are still difficult to manufacture. Nevertheless, such scaffolds can be designed and fabricated using three dimensional (3D) printing approaches. 3D printing technology, as an advanced tissue scaffold fabrication method, offers the opportunity to produce complex geometries with distinct advantages. The technology has been used for the production of various types of bodily constructs such as blood vessels, vascular networks, bones, cartilages, exoskeletons, eyeglasses, cell cultures, tissues, organs and novel drug delivery devices. This review focuses on 3D printed scaffolds and their application in bone repair and regeneration. In addition, different classes of biomaterials commonly employed for the fabrication of 3D nano scaffolds for bone tissue engineering application so far are briefly discussed.

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Section: Medical Application Of 3d Printingmentioning

confidence: 99%

Three dimensional printed nanostructure biomaterials for bone tissue engineering

Marew

Birhanu

2021

Regenerative Therapy

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“…Moreover, as both substances are important structural components of extracellular matrices on vertebrates and crustaceans, they can act as bioactive components for tissue regeneration. Such was the case in the contributions by Kavya et al [194] and Porgham Daryasari et al [195], who employed those elements to induce osteogenesis through two different approaches. In the first approach, Kavya et al designed a crosslinked chitosan/CS scaffold reinforced with nanometric SiO 2 .…”

Section: Delivery Of Glycan-based Biomoleculesmentioning

confidence: 98%

Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules

Castillo

Lozano

2020

Pharmaceutics

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The enormous versatility of mesoporous silica nanoparticles permits the creation of a large number of nanotherapeutic systems for the treatment of cancer and many other pathologies. In addition to the controlled release of small drugs, these materials allow a broad number of molecules of a very different nature and sizes. In this review, we focus on biogenic species with therapeutic abilities (proteins, peptides, nucleic acids, and glycans), as well as how nanotechnology, in particular silica-based materials, can help in establishing new and more efficient routes for their administration. Indeed, since the applicability of those combinations of mesoporous silica with bio(macro)molecules goes beyond cancer treatment, we address a classification based on the type of therapeutic action. Likewise, as illustrative content, we highlight the most typical issues and problems found in the preparation of those hybrid nanotherapeutic materials.

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“…These scaffolds can thus effectively control and stimulate the desired cellular responses and subsequent tissue reactions for bone regeneration [ 181 ]. In another study, a composite scaffold of PLLA incorporated dexamethasone loaded MSNs coated with chitosan (MSNs-DEX@CS/PLLA) were prepared to enhance the osteogenic potential of pure poly-l-lactic acid (PLLA) scaffolds [ 182 ]. These MSN-based nanocarriers have a conductive surface that can improve the scaffold’s osteogenic potential, resulting in better control in the pH-sensitive delivery of dexamethasone at the site of implantation.…”

Section: Update On Msn Applications In Nanomedicinesmentioning

confidence: 99%

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

et al. 2021

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The efficient and safe delivery of therapeutic drugs, proteins, and nucleic acids are essential for meaningful therapeutic benefits. The field of nanomedicine shows promising implications in the development of therapeutics by delivering diagnostic and therapeutic compounds. Nanomedicine development has led to significant advances in the design and engineering of nanocarrier systems with supra-molecular structures. Smart mesoporous silica nanoparticles (MSNs), with excellent biocompatibility, tunable physicochemical properties, and site-specific functionalization, offer efficient and high loading capacity as well as robust and targeted delivery of a variety of payloads in a controlled fashion. Such unique nanocarriers should have great potential for challenging biomedical applications, such as tissue engineering, bioimaging techniques, stem cell research, and cancer therapies. However, in vivo applications of these nanocarriers should be further validated before clinical translation. To this end, this review begins with a brief introduction of MSNs properties, targeted drug delivery, and controlled release with a particular emphasis on their most recent diagnostic and therapeutic applications.

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Poly-l-lactic acid scaffold incorporated chitosan-coated mesoporous silica nanoparticles as pH-sensitive composite for enhanced osteogenic differentiation of human adipose tissue stem cells by dexamethasone delivery

Abstract: SadatMahdavi (2019) Poly-l-lactic acid scaffold incorporated chitosan-coated mesoporous silica nanoparticles as pH-sensitive composite for enhanced osteogenic differentiation of human adipose tissue stem cells by dexamethasone delivery,

Cited by 44 publications

References 43 publications

Three dimensional printed nanostructure biomaterials for bone tissue engineering

Three dimensional printed nanostructure biomaterials for bone tissue engineering

Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

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