Poly (L-glutamic acid)-Paclitaxel Conjugates for Cancer Treatment

Zhang, Shuang‐Qing

doi:10.5772/21474

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…To overcome these problems, various drug delivery systems (DDS) have been widely researched for cancer therapy in recent years. They exhibited several advantages, such as (a) improved water solubility of hydrophobic drugs, (b) reduced nonspecific uptake and side effects, (c) prolonging blood circulation time, and (d) enabling passive or active targeting of drugs to the tumor tissues [2]. Contemporary drug delivery research is focused on nanoscale delivery systems, such as polymeric prodrugs, liposomes, nanogels, polymeric nanoparticles, or micelles.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of pH-sensitive, water-soluble paclitaxel prodrugs based on norbornene-functional polylactide by copper-free click chemistry

Wang

Zhou

Zheng

et al. 2016

International Journal of Polymeric Materials and Polymeric Biom

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2016) Synthesis of pH-sensitive, water-soluble paclitaxel prodrugs based on norbornene-functional polylactide by copper-free click chemistry, International Journal of Polymeric Materials and Polymeric Biomaterials, 65:15,[789][790][791][792][793][794][795][796] ABSTRACT In this study, a novel polymeric prodrug based on norbornene-functional polylactide with functionalized paclitaxels (LEV-PTXL) covalently conjugated to water-soluble polymer carrier via a pH-sensitive hydrazone bond was developed. A series of water-soluble PTXL prodrugs with decent drug contents of 17.3 and 24.7 wt% (denoted as PTXL prodrugs 1 and 2) were prepared. The molecular structures and characteristics were confirmed by 1 H NMR, Fourier transform infrared, and gel permeation chromatography. In vitro release studies showed that PTXL release rate from polymeric prodrug were significantly accelerated under acidic medium, due to the acid-cleavable hydrazone linkage. As illustrated by cytotoxicity study, while the corresponding polymer carrier was nontoxic, the polymeric prodrug exhibited higher therapeutic efficacy toward MCF-7 and A549 (IC50 ¼ 0.19 and 4.94 µg PTXL equiv/mL, respectively) cancer cells. The norbornene-functional polylactide-based polymeric prodrug has appeared as a novel anticancer nanomedicine for cancer therapy. GRAPHICAL ABSTRACT ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Synthesis of pH-sensitive, water-soluble paclitaxel prodrugs based on norbornene-functional polylactide by copper-free click chemistry

Wang

Zhou

Zheng

et al. 2016

International Journal of Polymeric Materials and Polymeric Biom

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Nanomedicines Based Drug Delivery Systems for Anti-Cancer Targeting and Treatment

Jain¹,

Jain²,

Mahajan³

2015

CDD

113

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Cancer is defined as an uncontrolled growth of abnormal cells. Current treatment strategies for cancer include combination of radiation, chemotherapy and surgery. The long-term use of conventional drug delivery systems for cancer chemotherapy leads to fatal damage of normal proliferate cells and this is particularly used for the management of solid tumors, where utmost tumor cells are not invaded quickly. A targeted drug delivery system (TDDS) is a system, which releases the drug at a preselected biosite in a controlled manner. Nanotechnology based delivery systems are making a significant impact on cancer treatment and the polymers play key role in the development of nanopraticlulate carriers for cancer therapy. Some important technological advantages of nanotherapeutic drug delivery systems (NDDS) include prolonged half-life, improved bio-distribution, increased circulation time of the drug, controlled and sustained release of the drug, versatility of route of administration, increased intercellular concentration of drug and many more. This review covers the current research on polymer based anticancer agents, the rationale for development of these polymer therapeutical systems and discusses the benefits and challenges of cancer nanomedicines including polymer-drug conjugates, micelles, dendrimers, immunoconjugates, liposomes, nanoparticles.

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Poly (L-glutamic acid)-Paclitaxel Conjugates for Cancer Treatment

Cited by 2 publications

References 38 publications

Synthesis of pH-sensitive, water-soluble paclitaxel prodrugs based on norbornene-functional polylactide by copper-free click chemistry

Synthesis of pH-sensitive, water-soluble paclitaxel prodrugs based on norbornene-functional polylactide by copper-free click chemistry

Nanomedicines Based Drug Delivery Systems for Anti-Cancer Targeting and Treatment

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