Poly(HEMA)-collagen composite as a biomaterial for hard tissue replacement

Štol, M.; Smetana, Karel; Korbelár, P; Adam, M.

doi:10.1016/0267-6605(93)90084-k

Cited by 8 publications

(2 citation statements)

References 14 publications

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“…Poly-HEMA, which was used as the main monomer in this study, is widely used as a hydrophilic and biocompatible material, and is generally known to be safe to attach directly to the body surface. [15] DMAPM was used to introduce amino groups into the phenylborate copolymers to enhance the binding ability of VPBA with glucose. This is why cationic amino groups in DMAPM are likely to induce anionic PBA on the basis of an electrostatic interaction, resulting in the enhanced responsibility of VPBA in the hydrogel to glucose, as shown in Scheme 1.…”

Section: Resultsmentioning

confidence: 99%

Glucose-responsive hydrogel electrode for biocompatible glucose transistor

Kajisa¹,

Sakata

2017

Science and Technology of Advanced Materials

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In this paper, we propose a highly sensitive and biocompatible glucose sensor using a semiconductor-based field effect transistor (FET) with a functionalized hydrogel. The principle of the FET device contributes to the easy detection of ionic charges with high sensitivity, and the hydrogel coated on the electrode enables the specific detection of glucose with biocompatibility. The copolymerized hydrogel on the Au gate electrode of the FET device is optimized by controlling the mixture ratio of biocompatible 2-hydroxyethylmethacrylate (HEMA) as the main monomer and vinylphenylboronic acid (VPBA) as a glucose-responsive monomer. The gate surface potential of the hydrogel FETs shifts in the negative direction with increasing glucose concentration from 10 μM to 40 mM, which results from the increase in the negative charges on the basis of the diol-binding of PBA derivatives with glucose molecules in the hydrogel. Moreover, the hydrogel coated on the gate suppresses the signal noise caused by the nonspecific adsorption of proteins such as albumin. The hydrogel FET can serve as a highly sensitive and biocompatible glucose sensor in in vivo or ex vivo applications such as eye contact lenses and sheets adhering to the skin.

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Section: Resultsmentioning

confidence: 99%

Glucose-responsive hydrogel electrode for biocompatible glucose transistor

Kajisa¹,

Sakata

2017

Science and Technology of Advanced Materials

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“…HEMA is a hydrophilic monomer and is using in biomedical field [21]. Poly(HEMA) has also adequate biocompatibility and uses in medical science as implant [22]. The goal of this research work is to determine the influence of PG and HEMA on the preparation of a bio-artificial polymeric material using gelatin polymer that would be used as an excellent alternative to tissue scaffold material for artificial bone tissue engineering and drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Phosphate Glass Reinforced Gelatin Blend Bioactive Composite Films

Dey

Alamgir

Parvin

et al. 2014

J. Res. Updates Polym. Sci.

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Bioactive composite films were prepared using bioresorbable phosphate glass powder and biodegradable polymer gelatin (G) through solution casting process. Biocompatible monomer, 2-hydroxyethyl methacrylate (HEMA) was used as the cross-linking agent and bioresorbable phosphate glass (PG) powder was used as reinforcement filler. The composite films were obtained at various ratios of G, PG and HEMA. The PG modified gelatin composite (PG/G) film was fabricated at a weight ratio of 12:88 while HEMA modified gelatin composite (HEMA/G) film at 50:50 ratio. On the other hand, hybrid gelatin composite film, containing both PG and HEMA, was obtained using a G/PG/HEMA ratio of 44:12:44. Incorporation of PG improved the mechanical properties of the composite films. Morphological property of the composite films was investigated by stereo microscope and it revealed that the composite films were porous in nature. The thermal behaviour of the films was studied using thermogravimetric analysis. Water uptake of the films was also performed.

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