Poly (glycerol sebacate)-poly (ε-caprolactone) blend nanofibrous scaffold as intrinsic bio- and immunocompatible system for corneal repair

Salehi, Sahar; Czugala, Marta; Stafiej, Piotr; Fathi, Mohammadhossein; Bahners, Thomas; Gutmann, Jochen S.; Singer, Bernhard B.; Fuchsluger, Thomas Armin

doi:10.1016/j.actbio.2017.01.013

Cited by 69 publications

(58 citation statements)

References 52 publications

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“…Poly(glycerol-sebacate) (PGS), a biocompatible and biodegradable soft elastomer first introduced by Wang and co-workers [6], has recently attracted much attention since its properties appeared to be particularly interesting for regenerative medicine. PGS has been studied for a broad range of applications including cardiovascular patches [7,8], heart valves [9], as well as for cartilage [10,11], bone [12], corneal [13] and nerve [14,15] tissue engineering, for the retina [16,17] and tympanic membrane healing [18,19]. Synthesis of PGS involves a two-step procedure: First, the PGS pre-polymer (PGS p ) is synthesized from pre-polycondensation of glycerol and sebacic acid, then the cross-linked polymer can be obtained by additional vacuum heat treatment of the PGS p precursor.…”

Section: Introductionmentioning

confidence: 99%

Electrospun PCL/PGS Composite Fibers Incorporating Bioactive Glass Particles for Soft Tissue Engineering Applications

et al. 2020

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Poly(glycerol-sebacate) (PGS) and poly(epsilon caprolactone) (PCL) have been widely investigated for biomedical applications in combination with the electrospinning process. Among others, one advantage of this blend is its suitability to be processed with benign solvents for electrospinning. In this work, the suitability of PGS/PCL polymers for the fabrication of composite fibers incorporating bioactive glass (BG) particles was investigated. Composite electrospun fibers containing silicate or borosilicate glass particles (13-93 and 13-93BS, respectively) were obtained and characterized. Neat PCL and PCL composite electrospun fibers were used as control to investigate the possible effect of the presence of PGS and the influence of the bioactive glass particles. In fact, with the addition of PGS an increase in the average fiber diameter was observed, while in all the composite fibers, the presence of BG particles induced an increase in the fiber diameter distribution, without changing significantly the average fiber diameter. Results confirmed that the blended fibers are hydrophilic, while the addition of BG particles does not affect fiber wettability. Degradation test and acellular bioactivity test highlight the release of the BG particles from all composite fibers, relevant for all applications related to therapeutic ion release, i.e., wound healing. Because of weak interface between the incorporated BG particles and the polymeric fibers, mechanical properties were not improved in the composite fibers. Promising results were obtained from preliminary biological tests for potential use of the developed mats for soft tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Electrospun PCL/PGS Composite Fibers Incorporating Bioactive Glass Particles for Soft Tissue Engineering Applications

et al. 2020

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“…The recent three years brought a few more publications from the scope of PGS electrospinning, with a focus on applications for soft tissue engineering and nerve tissue engineering [19][20][21][22][23][24][25], and a few more about the electrospinning process with PGS as one of the components [26][27][28][29][30][31]. None of them, however, were devoted to investigations of electrospinning of PLA-PGS blends.…”

mentioning

confidence: 99%

Poly(Glycerol Sebacate)–Poly(l-Lactide) Nonwovens. Towards Attractive Electrospun Material for Tissue Engineering

2019

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Two types of poly(glycerol sebacate) (PGS) prepolymers were synthesized and electrospun with poly(l-lactic acid) (PLA), resulting in bicomponent nonwovens. The obtained materials were pre-heated in a vacuum, at different times, to crosslink PGS and investigate morphological and structural dependencies in that polymeric, electrospun system. As both PGS and PLA are sensitive to pre-heating (crosslinking) conditions, research concerns both components. More interest is focused on the properties of PGS, considering further research for mechanical properties and subsequent experiments with PGS synthesis. Electrospinning of PGS blended with PLA does not bring difficulties, but obtaining elastomeric properties of nonwovens is problematic. Even though PGS has many potential advantages over other polyesters when soft tissue engineering is considered, its full utilization via the electrospinning process is much harder in practice. Further investigations are ongoing, especially with the promising PGS prepolymer with a higher esterification degree and its variations.

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“…[ 96 ] As a result, PGSp must be blended with a spinnable carrier polymer to allow non‐destructive fiber formation by electrospinning. According to its specific application ranging from soft to hard TE also including drug delivery, synthetic polymers like PCL, [ 16,19,21,29,33,38,45,97–111 ] poly(vinyl alcohol) (PVA), [ 96,112–114 ] poly(butylene succinate‐ co ‐dilinoleic succinate) PBS‐DLS, [ 115,116 ] PLA, [ 117 ] poly( l ‐lactic acid) (PLLA), [ 118,119 ] (PEO), [ 120 ] PLGA, [ 121,122 ] polyethersulfone (PSF), [ 123 ] polyhydroxybutyrate (PHB), [ 124 ] polyvinylpyrrolidone (PVP), [ 125,126 ] TPU, [ 35 ] and natural polymers like collagen, [ 127 ] gelatin, [ 128 ] fibrinogen, [ 129 ] zein, [ 130,131 ] and chitin and lignin [ 132 ] have been used for blending with PGS for successful electrospinning. Additional to blending PGS with another polymer, electrospinning of PGS within a core–shell system has been reported too where the sacrificial polymer is used as a shell which will be removed after PGS cross‐linking.…”

Section: Fabrication Techniques For Pgs‐based Biomaterialsmentioning

confidence: 99%

Poly(Glycerol Sebacate) in Biomedical Applications—A Review of the Recent Literature

Vogt

Ruther

Salehi

et al. 2021

Adv Healthcare Materials

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100

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Poly(glycerol sebacate) (PGS) continues to attract attention for biomedical applications owing to its favorable combination of properties. Conventionally polymerized by a two‐step polycondensation of glycerol and sebacic acid, variations of synthesis parameters, reactant concentrations or by specific chemical modifications, PGS materials can be obtained exhibiting a wide range of physicochemical, mechanical, and morphological properties for a variety of applications. PGS has been extensively used in tissue engineering (TE) of cardiovascular, nerve, cartilage, bone and corneal tissues. Applications of PGS based materials in drug delivery systems and wound healing are also well documented. Research and development in the field of PGS continue to progress, involving mainly the synthesis of modified structures using copolymers, hybrid, and composite materials. Moreover, the production of self‐healing and electroactive materials has been introduced recently. After almost 20 years of research on PGS, previous publications have outlined its synthesis, modification, properties, and biomedical applications, however, a review paper covering the most recent developments in the field is lacking. The present review thus covers comprehensively literature of the last five years on PGS‐based biomaterials and devices focusing on advanced modifications of PGS for applications in medicine and highlighting notable advances of PGS based systems in TE and drug delivery.

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Poly (glycerol sebacate)-poly (ε-caprolactone) blend nanofibrous scaffold as intrinsic bio- and immunocompatible system for corneal repair

Cited by 69 publications

References 52 publications

Electrospun PCL/PGS Composite Fibers Incorporating Bioactive Glass Particles for Soft Tissue Engineering Applications

Electrospun PCL/PGS Composite Fibers Incorporating Bioactive Glass Particles for Soft Tissue Engineering Applications

Poly(Glycerol Sebacate)–Poly(l-Lactide) Nonwovens. Towards Attractive Electrospun Material for Tissue Engineering

Poly(Glycerol Sebacate) in Biomedical Applications—A Review of the Recent Literature

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