Poly(ethylene oxide)–poly(propylene oxide) block copolymer micelles as drug delivery agents: Improved hydrosolubility, stability and bioavailability of drugs

Chiappetta, Diego Andrés; Sosnik, Alejandro

doi:10.1016/j.ejpb.2007.03.022

Cited by 519 publications

(370 citation statements)

References 161 publications

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“…In contrast, hydrophobic blocks form the inner micellar core, a hydrophobic domain, which facilitates the incorporation of poorly water soluble drugs by physical interaction or chemical conjugation leading to higher solubility extents (Croy et al, 2006). PEO-PPO [poly-(ethylene oxide)-poly-(propylene oxide)] block copolymers (linear poloxamers and branched poloxamines) are some of the significant commercially available micelle forming materials approved by Food and Drug Administration (Chiappetta et al, 2007). Polymeric micelles are more stable than the conventional micelles even at concentration below CMC (Sosnik et al, 2010).…”

Section: Figmentioning

confidence: 99%

Interaction of Nanoparticles in Biological Systems and their Role in Therapeutical Treatment of Tuberculosis and Cancer

Meena¹,

Singh²,

Sahare³

et al. 2014

JLA

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The kind of interactions which nanoparticles show in the biological systems is very interesting. Nanoparticles (NPs) on entering the living system immediately come in contact with proteins which serve many applications of nanoparticles including bio-signalling, therapeutics and drug delivery systems. Moreover, many inorganic oxide nanoparticles can also serve the purpose of antibacterial/antiviral by assisting in the production of reactive oxygen species (ROS). The role of nanoparticles in therapeutics is very significant and increasing day-by-day as it assures better treatment to the patient by enhancing activity of drug, improving bioavailability, flexibility in deciding route of administration and long term stability of drug resulting in better treatments of diseases. NPs such as solid lipid NPs, polymeric NPs, porous NPs, liposomes are being used for treatment of various types of diseases. Numerous carriers based drug delivery systems incorporating anti-TB drugs have been developed for target site actions. NPs encapsulating anti-cancer drugs such as doxorubicin, paclitaxel have also been developed for treatment of different types of cancers. Results of these studies give hopes to the researchers for the use of nanoparticles in the field of therapeutics. The NPs can be toxic as well as nontoxic to the biological system. Therefore, some adverse effects, such as, cytotoxicity on inhaling some kinds of nanoparticles must be kept in mind for judicious use of such systems during synthesis or during handling. The paper describes recent developments in the field by reviewing the available literature.

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Section: Figmentioning

confidence: 99%

Interaction of Nanoparticles in Biological Systems and their Role in Therapeutical Treatment of Tuberculosis and Cancer

Meena¹,

Singh²,

Sahare³

et al. 2014

JLA

View full text Add to dashboard Cite

show abstract

“…However, the commercially available Pluronic preparations may contain admixtures of the PO homopolymer as well as di-and triblock copolymers, exhibiting lower degrees of polymerization than expected [29]. These copolymers are available in a wide range of molecular weights and EO/PO ratios [1]. They have amphiphilic properties characterised by their HLB values (hydrophilic-lipophilic balance), in which the number of hydrophilic EO (x) and hydrophobic PO (y) units can be altered to vary the size, hydrophilicity and lipophilicity easily [27,29].…”

Section: Introductionmentioning

confidence: 99%

“…Due to the hydrophobic nature of the core, these entities particularly suitable for the solubilization of water insoluble molecules, protection of unstable agents from chemical degradation and metabolism by biological agents, and sustained release in different formulations [1,5]. Among the polymers displaying micelleformation ability, the most broadly investigated amphiphilic materials are derivatives of PEO-PPO block copolymers [1,6,7] which form swellable hydrogels. Swollen hydrogels, which give more emollient effect than conventional ointments due to their high water content, have been preferred for topical-transdermal drug delivery in recent years.…”

Section: Introductionmentioning

confidence: 99%

“…Polymeric micelles are nanoscopic (> 100 nm) structures formed by amphiphilic block copolymers composed of hydrophilic and hydrophobic chains that selfassemble in water, above a certain concentration named the critical micelle concentration (CMC) [1,4]. Micelles comprise of an inner and outer domain referred to as core and shell, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…However, a persisting drawback is low solubility in physiological aqueous environment of about 50 % of approved active molecules, resulting in poor bioavailability [1]. Limited solubility also constitutes a hurdle in the development of topical formulations, and improved solubility usually correlates well with higher bioavailability [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Poly(ethylene oxide)–Poly(propylene oxide)-Based Copolymers for Transdermal Drug Delivery: An Overview

Yapar¹,

Ýnal²

2013

Trop. J. Pharm Res

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Stimuli‐Responsive Materials for Controlled Release of Theranostic Agents

Wang

Shim

Levinson

et al. 2014

Adv Funct Materials

316

193

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Stimuli-responsive materials are so named because they can alter their physicochemical properties and/or structural conformations in response to specific stimuli. The stimuli can be internal, such as physiological or pathological variations in the target cells/tissues, or external, such as optical and ultrasound radiations. In recent years, these materials have gained increasing interest in biomedical applications due to their potential for spatially and temporally controlled release of theranostic agents in response to the specific stimuli. This article highlights several recent advances in the development of such materials, with a focus on their molecular designs and formulations. The future of stimuli-responsive materials will also be explored, including combination with molecular imaging probes and targeting moieties, which could enable simultaneous diagnosis and treatment of a specific disease, as well as multi-functionality and responsiveness to multiple stimuli, all important in overcoming intrinsic biological barriers and increasing clinical viability.

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Poly(ethylene oxide)–poly(propylene oxide) block copolymer micelles as drug delivery agents: Improved hydrosolubility, stability and bioavailability of drugs

Cited by 519 publications

References 161 publications

Interaction of Nanoparticles in Biological Systems and their Role in Therapeutical Treatment of Tuberculosis and Cancer

Interaction of Nanoparticles in Biological Systems and their Role in Therapeutical Treatment of Tuberculosis and Cancer

Poly(ethylene oxide)–Poly(propylene oxide)-Based Copolymers for Transdermal Drug Delivery: An Overview

Stimuli‐Responsive Materials for Controlled Release of Theranostic Agents

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