Poly(ethylene oxide)-Based Delivery Systems

Apicella, A.; Cappello, B; Nobile, Mario; Rotonda, Maria Immacolata La; Mensitieri, Giuseppe; Nicolais, L.; Seccia, S.

doi:10.1021/bk-1994-0545.ch009

Cited by 10 publications

(8 citation statements)

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“…However, for a higher molecular weight PEO tablet (4 x lo6) the synchronized gel layer is not obtained and the gel layer thickness keeps increasing, as observed from HPMC matric~s .~J O This observation is in good agreement with results obtained by others. 13 It was observed that the swollen PEO gel, even after the front meets at the core of tablets, lasts a much longer time, 2 to 4 h depending upon the PEO molecular weight, compared to other swellable/erodible polymers such as P M W A A and PVA.5J5 As a result, it is expected that the release kinetics are governed by the erosioddrug diffusion process aRer the swelling front meets at the core of the tablet. with the increasing molecular weight of PEOs of 0.9 x lo6, 2…”

Section: Resultsmentioning

confidence: 99%

“…m Abstract published in Advance ACS Abstracts, February 1, 1995. Cross-linked poly(ethy1ene oxide) (PEO) has been investigated for controlled drug delivery.12 However, it has been shown recently that drug release from un-cross-linked low molecular weight PEO of MW = 0.6 x lo6 (laminated films) ensures a constant release rate by achieving synchronized gel thickness. 13 On the other hand, the drug release from the high molecular weight PEO of MW = 4 x lo6 is predominantly controlled by the swelling of the polymer rather than by the erosion of the polymer. This results in a nonconstant release induced by the diffusion of drugs through the swollen gel layer.…”

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confidence: 99%

“…This results in a nonconstant release induced by the diffusion of drugs through the swollen gel layer. 13 In this study, some factors affecting the release of drugs from compressed PEO tablets are presented: molecular weight, stirring rate, drug solubility, and drug loading.…”

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Drug Release from Compressed Hydrophilic POLYOX‐WSR Tablets

Kim

1995

Journal of Pharmaceutical Sciences

107

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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Drug Release from Compressed Hydrophilic POLYOX‐WSR Tablets

Kim

1995

Journal of Pharmaceutical Sciences

107

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“…The higher release rates displayed by the alginate capsules, which exhibited the lowest erosion, could be attributed mainly to the loose swollen gelatinous mass. This mass facilitates liquid penetration and provides increased free volume, greater contact area between the poorly soluble furosemide and the dissolution medium, higher drug diffusivity, and therefore faster release [18]. Furthermore, in capsules swelling is more pronounced and the quantity of absorbed medium is higher, favoring drug release.…”

Section: Drug-release Studiesmentioning

confidence: 99%

Development and Evaluation of oral multiple-unit and single-unit hydrophilic controlled-release systems

2000

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This study compared the release behavior of single-unit (tablets, capsules) and multipleunit (minitablets in capsules) controlled-release systems of furosemide. The swelling and erosion behaviors of these systems, which contained the swellable hydrophilic polymers sodium alginate (high viscosity) and Carbopol 974P, were compared. Swelling and erosion experiments showed a high degree of swelling and limited erosion for the Carbopol preparations, whereas less swelling but greater erosion was observed for the sodium alginate preparations. The sodium alginate preparations were eroded in 6 hours, while Carbopol preparations exhibited limited erosion within this period of time. These results appear to be attributed to the physicochemical characteristics of the polymers used in this study. Polymer characteristics greatly influenced the release of furosemide (model drug) from the formulations prepared and tested. Sodium alginate had a less pronounced sustained release effect compared with Carbopol (ie, in 8 hours all 3 sodium alginate dosage forms displayed complete release of furosemide, while only 30% of the drug was released from Carbopol dosage forms). Finally, all 3 Carbopol dosage forms (single-and multiple-unit) displayed similar release behavior while sodium alginate dosage forms displayed a different and more distinctive behavior. Minitablets and tablets showed a greater sustained release effect compared with capsules. Evaluation of the release data indicates that the release mechanism for sodium alginate formulations may be attributed to erosion/dissolution, while for Carbopol it may be attributed mainly to polymer relaxation and diffusion of the drug from the polymer surface.

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“…Polymers are by far the most used drugdelivery systems, the most used being polyethylene glycol (PEG), polyethylene oxide, poly εcaprolactone, chitosan, alginate, polyvinyl alcohol (PVA), polymethyl methacrylate, cellulose, etc. [56][57][58][59][60][61][62][63][64][65][66][67] Also, proteins (collagen being the most abundant) are known as support for drugdelivery systems, but usually their high chemical and physical instability present technical problems related to synthesis and storage. [68][69][70][71] PVA is extremely useful for chemoembolization, and in certain conditions can be loaded with various antitumoral drugs, such as cisplatin, doxorubi cin, mitomycin C, and ethiodol.…”

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confidence: 99%

Multifunctional materials for bone cancer treatment

Marques¹,

Ferreira²,

Andronescu³

et al. 2014

IJN

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The purpose of this review is to present the most recent findings in bone tissue engineering. Special attention is given to multifunctional materials based on collagen and collagen–hydroxyapatite composites used for skin and bone cancer treatments. The multi-functionality of these materials was obtained by adding to the base regenerative grafts proper components, such as ferrites (magnetite being the most important representative), cytostatics (cisplatin, carboplatin, vincristine, methotrexate, paclitaxel, doxorubicin), silver nanoparticles, antibiotics (anthracyclines, geldanamycin), and/or analgesics (ibuprofen, fentanyl). The suitability of complex systems for the intended applications was systematically analyzed. The developmental possibilities of multifunctional materials with regenerative and curative roles (antitumoral as well as pain management) in the field of skin and bone cancer treatment are discussed. It is worth mentioning that better materials are likely to be developed by combining conventional and unconventional experimental strategies.

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Poly(ethylene oxide)-Based Delivery Systems

Cited by 10 publications

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Drug Release from Compressed Hydrophilic POLYOX‐WSR Tablets

Drug Release from Compressed Hydrophilic POLYOX‐WSR Tablets

Development and Evaluation of oral multiple-unit and single-unit hydrophilic controlled-release systems

Multifunctional materials for bone cancer treatment

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