Poly(ethylene glycol) dicarboxylate/poly(ethylene oxide) hydrogel film co-crosslinked by electron beam irradiation as an anti-adhesion barrier

Haryanto,; Singh, Deepti; Han, Sung Soo; Son, Jun Hyuk; Kim, Seong Cheol

doi:10.1016/j.msec.2014.10.028

Cited by 17 publications

(6 citation statements)

References 39 publications

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“…However, gamma rays unavoidably produce nuclear waste (Nasef 2004) and provide a lower irradiation dose, which limits the variety of materials being grafted (Kim and Huh 2012). Intensive studies have been conducted to assess the ability of EB irradiation to graft/copolymerize functional components on various thermoplastic and thermoset polymers (Gürsel et al 2008; Haryanto et al 2015); thus, MDPB could be grafted onto other types of dental resins, such as (di)methacrylate-based resin used for restorative treatments. However, the proper determination of the coating/irradiation conditions is essential to accomplish grafting.…”

Section: Discussionmentioning

confidence: 99%

“…Among these techniques, radiation-induced grafting can initiate the covalently attached side chain of functional components on the activated sites of the polymer surface by using high-energy radiation (i.e., gamma rays, electron beams [EBs]; Nasef 2004) while avoiding unwanted chemical impurities (e.g., initiator residues), retarders, and accelerators (Haryanto et al 2015). It has been reportedly used for numerous decades in the biomedical, environmental, and industrial fields (Clough 2001; García-Vargas et al 2014; Pino-Ramos et al 2016; Amdjadi et al 2017).…”

Section: Introductionmentioning

confidence: 99%

“…It is also compatible and beneficial for indirect dental restorations that are custom-made and irregular in shape, owing to its capability to generate radicals on its surface and interior (Kim and Huh 2012). Here, the EB irradiation method was selected because the radiation dose is easily controlled (Haryanto et al 2015) and does not produce nuclear waste, which is unavoidable for gamma ray irradiation (Nasef 2004).…”

Section: Introductionmentioning

confidence: 99%

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Immobilizing Bactericides on Dental Resins via Electron Beam Irradiation

et al. 2021

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Polymerizable bactericides, such as quaternary ammonium compound–based monomers, have been intensively studied as candidates for immobilizing antibacterial components on dental resin. However, they predominantly exhibit a bacteriostatic behavior, rather than bactericidal, as the immobilized components are left with insufficient molecular movement to disrupt the bacterial surface structure through contact-mediated action. In this study, we developed a novel strategy to increase the density of the immobilized bactericide and enhance its antibacterial/antibiofilm properties by combining a surface-grafting technique with electron beam irradiation. A solution of the quaternary ammonium compound–based monomer, 12-methacryloyloxydodecylpyridinium bromide (MDPB), was coated on polymethyl methacrylate (PMMA) resin specimens at the concentrations of 30, 50, and 80 wt%. The coated resins were subsequently exposed to 10 MeV of electron beam irradiation at 50 and 100 kGy, followed by thermal stabilization at 60 °C. The antibacterial effect was evaluated by inoculating a Streptococcus mutans suspension on the coated PMMA resin samples, which exhibited bactericidal effects even after 28 d of aging ( P < 0.05, Tukey’s honestly significant difference test). Transmission electron microscopy and bacteriolytic activity evaluation revealed that the S. mutans cells had sustained membrane depolarization. Furthermore, the antibiofilm effects against S. mutans and bacteria collected from human saliva were assessed. The thickness and the percentage of membrane-intact cells of the S. mutans and multispecies biofilms formed on the MDPB-immobilized surfaces were significantly lower than the uncoated PMMA specimens, even after 28-d aging ( P < 0.05, Tukey’s honestly significant difference test). Thus, the immobilization of antibacterial MDPB via electron beam irradiation induced rapid membrane depolarization, increasing membrane permeability and eventually causing cell death. Our strategy substantially enhances the antibacterial properties of the resinous materials and inhibits biofilm formation, therefore demonstrating significant potential for preventing infectious diseases in the oral environment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Immobilizing Bactericides on Dental Resins via Electron Beam Irradiation

et al. 2021

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“…When the cells come into contact with the adjacent cell it will stop growing. 68 Since control (2D) sample has limited space and hence dead cells are observed due to growth constrain. HA nanowires provide larger surface area and high aspect ratio which permits the cell to proliferate for a longer period of time.…”

Section: Possible Growth Mechanism Of Ha Nanowiresmentioning

confidence: 99%

Enhanced cell viability of hydroxyapatite nanowires by surfactant mediated synthesis and its growth mechanism

Nathanael

Hong

et al. 2016

RSC Adv.

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“…The physical properties of anti-adhesion films can be adjusted by controlling the amount of cross-linking through the control of the E-Beam dose. Currently, the cross-linking state and its subsequent effects, such as changes in biodegradability, can be evaluated by measuring swelling through the immersion method and conducting preclinical experiments using mice [ 12 ]. These methods are invasive and nonquantitative; therefore, there is a need for a nondestructive, noncontact performance inspection method that can nondestructively monitor the degree of cross-linking of anti-adhesion films.…”

Section: Introductionmentioning

confidence: 99%

Terahertz Spectral Properties of PEO-Based Anti-Adhesion Films Cross-Linked by Electron Beam Irradiation

Bark

Maeng

Kim³

et al. 2022

Polymers

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We investigated the spectral property changes in anti-adhesion films, which were cross-linked and surface-modified through electron beam irradiation, using terahertz time-domain spectroscopy (THz-TDS). Polyethylene oxide (PEO), which is a biocompatible and biodegradable polymer, was the main component of these anti-adhesion films being manufactured for testing. The terahertz characteristics of the films were affected by the porosity generated during the freeze-drying and compression processes of sample preparation, and this was confirmed using optical coherence tomography (OCT) imaging. An anti-adhesion polymer film made without porosity was measured by using the THz-TDS method, and it was confirmed that the refractive index and absorption coefficient were dependent on the crosslinking state. To our knowledge, this is the first experiment on the feasibility of monitoring cross-linking states using terahertz waves. The THz-TDS method has potential as a useful nondestructive technique for polymer inspection and analysis.

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Poly(ethylene glycol) dicarboxylate/poly(ethylene oxide) hydrogel film co-crosslinked by electron beam irradiation as an anti-adhesion barrier

Cited by 17 publications

References 39 publications

Immobilizing Bactericides on Dental Resins via Electron Beam Irradiation

Immobilizing Bactericides on Dental Resins via Electron Beam Irradiation

Enhanced cell viability of hydroxyapatite nanowires by surfactant mediated synthesis and its growth mechanism

Terahertz Spectral Properties of PEO-Based Anti-Adhesion Films Cross-Linked by Electron Beam Irradiation

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