Poly(ethylene glycol)‐crosslinked fullerenes for high efficient phototherapy

Lee, Dong Jin; Ahn, Yong Sik; Youn, Yu Seok; Lee, Eun Seong

doi:10.1002/pat.3074

Cited by 22 publications

(11 citation statements)

References 26 publications

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“…prepared a carrier based on folic acid functionalized graphene with a pyrene‐γ‐CD ⋅ C 60 complex adsorbed at its surface through π–π interactions (GO‐FA‐CDx ⋅ C 60 ) . GO‐FA‐CDx ⋅ C 60 promoted folic acid receptor mediated cellular uptake and showed not only photoinduced cytotoxicity, but also photothermal activity toward HeLa cells …”

Section: Photoinduced Cytotoxicity Of Fullerenes Incorporated Into Somentioning

confidence: 99%

“…[78] GO-FA-CDx·C 60 promoted folic acid receptor mediated cellular uptake and showedn ot only photoinduced cytotoxicity,b ut also photothermal activity towardH eLa cells. [79,80] Calvaresi et al reportedt hat lysozyme was able to disperse even pristine C 60 monomolecularly in water with a1 :1 stoichi- ometry. [81,82] The lysozyme·C 60 complexp roduced 1 O 2 following visible-light irradiation and showedp hotoinduced cytotoxicity toward HeLa cells.…”

Section: Photoinduced Cytotoxicities Of C 60mentioning

confidence: 99%

See 1 more Smart Citation

Photodynamic Activity of Fullerene Derivatives Solubilized in Water by Natural‐Product‐Based Solubilizing Agents

Antoku

Sugikawa

Ikeda

2018

Chemistry A European J

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Water-soluble fullerenes prepared by using solubilizing agents based on natural products are promising photosensitizers for photodynamic therapy. Cyclodextrin, β-1,3-glucan, lysozyme, and liposomes can stably solubilize not only C and C , but also some C derivatives in water. To improve the solubilities of fullerenes, specific methods have been developed for each solubilizing agent. Water-soluble C and C exhibit photoinduced cytotoxicity under near-ultraviolet irradiation, but not at wavelengths over 600 nm, which are the appropriate wavelengths for photodynamic therapy. However, dyad complexes of solubilized C derivatives combined with light-harvesting antenna molecules improve the photoinduced cytotoxicities at wavelengths over 600 nm. Furthermore, controlling the fullerene and antenna molecule positions within the solubilizing agents affects the performance of the photosensitizer.

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Section: Photoinduced Cytotoxicity Of Fullerenes Incorporated Into Somentioning

confidence: 99%

Section: Photoinduced Cytotoxicities Of C 60mentioning

confidence: 99%

Photodynamic Activity of Fullerene Derivatives Solubilized in Water by Natural‐Product‐Based Solubilizing Agents

Antoku

Sugikawa

Ikeda

2018

Chemistry A European J

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“…Besides, the arthritic foot surface temperature of the mice increased to 45°C after 2h injection. The generated ROS efficiently inhibited arthritic progress after 5 days irradiation [127].…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 95%

Biological applications of hydrophilic C60 derivatives (hC60s)− a structural perspective

Zhu

Sollogoub

Zhang

2016

European Journal of Medicinal Chemistry

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Abstract:Reactive oxygen species (ROS) generation and radical scavenging are dual properties of hydrophilic C60 derivatives (hC60s). hC60s eliminate radicals in dark, while they produce reactive oxygen species (ROS) in the presence of irradiation and oxygen. Compared to the pristine C60 suspension, the aqueous solution of hC60s is easier to handle in vivo. hC60s are diverse and could be placed into two general categories: covalently modified C60 derivatives and pristine C60 solubilized non-covalently by macromolecules. In order to present in detail, the above categories are broken down into 8 parts: C60(OH)n, C60 with carboxylic acid, C60 with quaternary ammonium salts, C60 with peptide, C60 containing sugar, C60 modified covalently or non-covalently solubilized by cyclodextrins (CDs), pristine C60 delivered by liposomes, functionalized C60-polymer and pristine C60 solubilized by polymer. Each hC60 shows the propensity to be ROS producer or radical scavenger. This preference is dependent on hC60s structures. For example, major application of C60(OH)n is radical scavenger, while pristine C60/γ-CD complex usually serves as ROS producer. In addition, the electron acceptability and innate hydrophobic surface confer hC60s with O2 uptake inhibition, HIV inhibition and membrane permeability. In this review, we summarize the preparation methods and biological applications of hC60s according to the structures.

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“…In this connection, multimeric conjugate of chlorin e 6 , folate and C 60 79 presents a special interest for application in the combined photothermal/photodynamic therapy of cancer. [78] The conjugate 79 synthesis is shown at the Scheme 19. Chlorin e 6 and folate were activated with DCC and N-hydroxysuccinimide (NHS) to form the respective succinates.…”

Section: Porphyrin-and Chlorin-fullerenes and Pdtmentioning

confidence: 99%