Poly(ethylene glycol) as a 'green solvent’ for the RAFT polymerization of methyl methacrylate

West, Andrew; Barner‐Kowollik, Christopher; Perrier, Sébastien

doi:10.1016/j.polymer.2010.06.022

Cited by 31 publications

(24 citation statements)

References 50 publications

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“…An appealing solution to the problem is the use of living radical polymerization techniques, which have offered the same control over molecular weight as well as low polydispersity for polymers. In particular, reversible addition–fragmentation chain transfer (RAFT) polymerization is an attractive approach for making well‐defined polymers because of its applicability to a wide range of monomers, suitability for a broad range of functional groups, and tolerance to various solvents . Therefore, it was postulated that the use of RAFT polymerization would be an ideal methodology for the preparation of a wide variety of polymers that could be used for the fabrication of gels.…”

Section: Introductionmentioning

confidence: 99%

Phenylboronate-diol crosslinked polymer/SWCNT hybrid gels with reversible sol-gel transition

Liu

Chen

et al. 2013

Polym. Adv. Technol.

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This work demonstrates the successful incorporation of functionalized single‐walled carbon nanotubes (f‐SWCNTs) into the phenylboronate‐diol crosslinked polymer gel to create a hybrid system with reversible sol–gel transition. The phenylboronic acid‐containing and diol‐containing polymers were first separately prepared by the reversible addition–fragmentation chain transfer polymerization. Covalent functionalization of single‐walled carbon nanotubes (SWCNTs) with an azide‐derivatized, diol‐containing polymer was then accomplished by a nitrene addition reaction. Subsequently, the hybrid gels were prepared by crosslinking the mixture of f‐SWCNTs and diol‐containing polymer with the phenylboronic acid‐containing polymer. The hybrid gel has been characterized by scanning electron microscopy (SEM) and rheological analysis. The SEM measurement demonstrated a homogeneous dispersion of f‐SWCNTs within the gel matrices. Rheological experiments also demonstrated that the hybrid gel exhibited storage moduli significantly higher than those of the native gel obtained from the phenylboronic acid‐containing and diol‐containing polymers. The hybrid gel can be switched into their starting polymer (f‐SWCNTs) solutions by adjusting the pH of the system. Moreover, the hybrid gel revealed a self‐healing property that occurred autonomously without any outside intervention. By employing this dynamic character, it is possible to regenerate the used gel, and thus, it has the potential to perform in a range of dynamic or bioresponsive applications Copyright © 2013 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Phenylboronate-diol crosslinked polymer/SWCNT hybrid gels with reversible sol-gel transition

Liu

Chen

et al. 2013

Polym. Adv. Technol.

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“…Moreover, such solvents have been advocated to be optimal media LRPs. [30][31] Encouraged by this observation, we first studied the RAFT (co)polymerizations of NIPAAM and Nisopropyl acrylamide mixed with polyethylene glycolmethylether acrylate (NIPAAM/PEGA) in DEG and in 1,4-dioxane, mediated by the succinimide bearing RAFT agent(SUCRA). In this experiment no nanoparticles were present.…”

Section: Polymerization Reaction Of Thermo-responsive Shell On the Ramentioning

confidence: 99%

Functionalization of Strongly Interacting Magnetic Nanocubes with (Thermo)Responsive Coating and Their Application in Hyperthermia and Heat-Triggered Drug Delivery

Kakwere

Leal

Materia

et al. 2015

ACS Appl. Mater. Interfaces

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Herein we prepare nanohybrids by incorporating iron oxide nanocubes (cubic-IONPs) within a thermo-responsive polymer shell that can act as drug carriers for doxorubicin(doxo). The cubic-shaped nanoparticles employed are at the interface between superparamagnetic and ferromagnetic behavior and have an exceptionally high specific absorption rate (SAR) but their functionalization is extremely challenging compared to bare superparamagnetic iron oxide nanoparticles as they strongly interact with each other. By conducting the polymer grafting reaction using reversible addition-fragmentation chain transfer (RAFT) polymerization in a viscous solvent medium, we have here developed a facile approach to decorate the nanocubes with stimuli-responsive polymers. When the thermo-responsive shell is composed of poly(N-isopropyl acrylamide-co-polyethylene glycolmethylether acrylate), nanohybrids have a phase transition temperature, the lower critical solution temperature (LCST), above 37 °C in physiological conditions. Doxo loaded nanohybrids exhibited a negligible drug release below 37 °C but showed a consistent release of their cargo on demand by exploiting the capability of the nanocubes to generate heat under an alternating magnetic field (AMF). Moreover, the drug free nanocarrier does not 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 2 exhibit cytotoxicity even when administered at high concentration of nanocubes (1g/L of iron) and internalized at high extent (260 pg of iron per cell). We have also implemented the synthesis protocol to decorate the surface of nanocubes with poly(vinylpyridine) polymer and thus prepare pH-responsive shell coated nanocubes.

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“…Among the controlled / living radical polymerization techniques discovered in the last twenty years, nitroxide-mediated polymerization ATRP (Neugebauer 2015, Chmielarz 2016, Liu and Hobbs 2018, nitroxidemediated polymerization, NMP (Nicolas, Guillaneuf et al, 2013, Kermagoret and Gigmes 2016, Ballard, Aguirre et al, 2017and reversible addition-removal chain transfer (RAFT) (West, Barner-Kowollik et al, 2010, Yeole and Hundiwale 2011, Ma'Radzi, Sugihara et al, 2014, Sütekin and Güven 2018polymerization techniques have been used extensively in molecular architecture design. Sensitive polymer very welldefined displaying Molecular weight distributions, high end group suitability and various complex architectures are unique for the synthesis of materials.…”

Section: Introductionmentioning

confidence: 99%

“…There is little research in the literature with RAFT polymerization for block copolymers using PEG Macro RAFT agents. We anticipate that novel studies will contribute to create infrastructure for creating infrastructure for the preparation of block copolymers with high economic efficiency, preparation of new health, cosmetics and nano technological materials (West, Barner-Kowollik et al, 2010, Fu, Lei et al, 2017.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of PMMA-b-PEG-b- PMMA by controlled Polymerization Using Macro-RAFT Agents

BAĞLAN>

Yıldıko

Čakmak

et al. 2018

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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In this work controlled radical polymerization (CRP) of methyl methacrylate was carried out in the presence of the Poly(ethylene glycol)(PEG) xanthate reversible addition fragmentation (RAFT) chain transfer agent designated as (CTA 1) and (CTA 2). Firstly, PEGs having different molecular weights (400 and 600 g/mol) were reacted KOH and CS 2 and the terminated 4-chloro benzoyl chloride to obtain PEG-xathates. RAFT agent possessing PEG chain was used in the RAFT polymerization of MMA to yield PMMA-b-PEG-b-PMMA tri-block copolymers which can be used in various potential applications. With the gravimetric follow of the reaction, the control mechanism works well and the molecular weight has grown linearly. The structures of the synthesized macro RAFT agents and polymers were characterized by 1 H-NMR, 13 C-NMR and FT-IR spectroscopic methods.

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Poly(ethylene glycol) as a 'green solvent’ for the RAFT polymerization of methyl methacrylate

Cited by 31 publications

References 50 publications

Phenylboronate-diol crosslinked polymer/SWCNT hybrid gels with reversible sol-gel transition

Phenylboronate-diol crosslinked polymer/SWCNT hybrid gels with reversible sol-gel transition

Functionalization of Strongly Interacting Magnetic Nanocubes with (Thermo)Responsive Coating and Their Application in Hyperthermia and Heat-Triggered Drug Delivery

Synthesis of PMMA-b-PEG-b- PMMA by controlled Polymerization Using Macro-RAFT Agents

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