Poly(ɛ-caprolactone)nanocapsules as carrier systems for herbicides: Physico-chemical characterization and genotoxicity evaluation

Grillo, Renato; Santos, Nathália Zocal Pereira dos; Maruyama, Cíntia Rodrigues; Rosa, André Henrique; Lima, Renata de; Fraceto, Leonardo Fernandes

doi:10.1016/j.jhazmat.2012.06.019

Cited by 204 publications

(202 citation statements)

References 38 publications

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“…These values for MagPCL-NC zeta potential are in agreement with previous results presented 43 for PCL nanoparticles. The negative values reflect the presence of carboxylic groups at the polymer extremities, since PCL is a polyester [25,26].…”

Section: Optimization Of Maghemite-loaded Pcl Nanocapsulesmentioning

confidence: 99%

Superparamagnetic maghemite loaded poly (ε- caprolactone) nanocapsules : characterization and synthesis optimization

et al. 2014

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Iron oxide nanoparticles (ION) have been studied for essential applications, like detection of biological constituents (virus, bacterials, cell, nucleic acids, protein, enzyme, etc.), magnetic bioseparation and clinic therapy and diagnosis (such as MRI magnetic fluid and hyperthermia). In this work, γ-Fe 2 O 3 has been synthetized by a adapted sol-gel method and entraped in poly ε-caprolactone (PCL) nanocapsules. The superparamagnetic nanocapsules have been formulated by double emulsion evaporation method. Some variables affecting the polydispersity index, zeta potential surface and size of nanocapsules were studied aiming optimize the formulation process of maghemite-loaded PCL nanocapsules. The following parameters were selected: sonication time, PCL concentration in organic phase, PVA concentration in external aqueous phase and maghemite/PCL weight ratio. Under these experimental conditions, the resulting nanocapsules displayed a mean size of about 346 nm and a maghemite content of about 7.5 µg/mg of nanocapsules and superparamagnetic behaviour at room temperature.

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Section: Optimization Of Maghemite-loaded Pcl Nanocapsulesmentioning

confidence: 99%

Superparamagnetic maghemite loaded poly (ε- caprolactone) nanocapsules : characterization and synthesis optimization

et al. 2014

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“…It has also been observed that negligible metribuzin residue left in soil after wheat harvesting and this residue was within prescribed limit of EPA (Kumar et al 2010). The release of atrazine from polymeric matrix occurred by diffusion of AI through the matrix (Grillo et al 2012).…”

Section: +3mentioning

confidence: 85%

Polysaccharides as safer release systems for agrochemicals

Campos

Oliveira

Fraceto

et al. 2014

Agron. Sustain. Dev.

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Agrochemicals are used to improve the production of crops. Conventional formulations of agrochemicals can contaminate the environment, in particular in the case of intensive cropping. Hence, there is a need for controlledrelease formulations of agrochemicals such as polysaccharides to reduce pollution and health hazards. Natural polysaccharides are hydrophilic, biodegradable polymers. This article reviews the use of polysaccharides in the form of micro-and nanoparticles, beads and hydrogels. The main points are: (1) slow release formulations minimize environmental impact by reducing agrochemical leaching, volatilization and degradation. For example, 50 % of the encapsulated insecticide chlorpyrifos is released in 5 days, whereas free chlorpyrifos is released in 1 day. (2) Slow release formulations increase the water-holding capacity of soil. (3) Slow release formulations better control weeds in the long run. (4) Polymer-clay formulations store ionic plant nutrients. (5) Polymer hydrogel formulations reduce compaction, erosion, and water run-off. They increase soil permeability and aeration, infiltration rates, and microbial activity, and, in turn, plant performance. In conclusion, polysaccharide formulations can be used for safer use of agrochemicals.

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“…Nos últimos anos a tecnologia de liberação controlada/modificada tem ganhado destaque, pois ela emergiu como uma importante alternativa capaz de resolver alguns dos problemas que acompanham o uso de substâncias ativas de interesse em alguns setores, 6 como por exemplo o agrícola (pesticidas e herbicidas), [7][8][9][10][11] alimentício, [12][13] o farmacêutico, [14][15][16][17] e, ineditamente, poderá ser aplicada para os cátions metálicos essenciais às plantas visando o aumento da eficiência dos fertilizantes, ou seja, aumento da disponibilidade destes no solo, minimização dos impactos ambientais e garantia de um desenvolvimento mundial considerado sustentável. Esta tecnologia propicia a liberação dos princípios ativos no decorrer de um determinado tempo através de processos físico-químicos, tais como dessorção e/ou erosão, sendo capaz de permitir a alteração das propriedades físico-químicas dos ativos para a liberação controlada/adequada destes, 6,18 possibilitando a atuação de forma contínua e prolongada dos cátions metálicos.…”

Section: Introductionunclassified

“…Um deles é o cálculo da taxa de encapsulamento dos nutrientes na matriz polimérica, como também a concentração de nutriente que este sistema libera no decorrer de um determinado tempo. [6][7][8][9][10][11][12][13][14][15][16][17][18] Assim, são requeridas técnicas analíticas para a quantificação da concentração dos cátions metálicos nesses processos.…”

Section: Introductionunclassified

Otimização multivariada de metodologia para digestão de micropartículas poliméricas carreadoras de cátions metálicos

et al. 2016

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Recebido em 28/03/2016, aceito em 06/07/2016, publicado na web em 16/08/2016 MULTIVARIATE OPTIMIZATION OF METHODOLOGY FOR POLYMERIC MICROPARTICLE DIGESTION METALLIC CATION CARRIERS. There are not reports in the literature of digestion processes of metallic cation carrier microparticles. Multivariate experimental designs were utilized to ensure an appropriate digestion for further analysis by atomic absorption spectroscopy. It was used a heater plate and the polimeric degradation was evaluated utilizing an analyzer of total organic carbon (TOC). For the total carbon (TC) content, the full factorial design 2 4 pointed the significance of sample volume (V Am ), in relation to the variables acid volume (V Ac ), temperature (T) and digestion time (t). However, according to the normal distribution graph it was noted a possible significance of the T and t effects. The same was observed for TOC, including the V Am × V Ac × T effect suggestive of complex behavior. In the central composite design all variables were again studied and the V AM was significant, promoting a TC decreasing at the lower evaluated level. By ANOVA a quadratic model without lack of fit was found, with the significant quadratic term. The best digestion condition was: 5.00 mL of sample, 10.00 mL of nitric acid, 60 ºC and 90 min. The multivariate optimization allowed an efficient digestion, with the initial carbon concentration of 4.60 mg L -1 decreased to 0.55 mg L -1 .Keywords: metallic cations; polymeric microparticles; sample preparation; digestion; multivariate experimental designs. INTRODUÇÃOOs cátions metálicos são parte essencial dos fertilizantes, pois eles são responsáveis por várias funções nas plantas, que vão desde a participação na síntese de proteínas, até sua presença em enzimas que participam de processos da fotossíntese. 1-2 Fertilizantes ou adubos são compostos químicos inorgânicos ou orgânicos utilizados para propiciar os nutrientes essenciais ao desenvolvimento das plantas, e são aplicados na agricultura para um maior rendimento da produção. 3 No entanto, atualmente, estudos 4-5 demonstram que para a maioria dos fertilizantes usados, parte dos seus nutrientes são perdidos no ambiente, podendo ocasionar uma série de contaminações ambientais. Por exemplo, os fertilizantes que possuem em sua composição nitratos e fosfatos podem perder parte desses compostos em processos de lixiviação, propiciando o processo de eutrofização em águas de mananciais e lençóis freáticos. Ainda, os fertilizantes quando não aplicados de forma correta podem proporcionar desequilíbrios no ecossistema e aumento do número das fontes de toxicidade aguda e carcinogênicas para os seres humanos. [4][5] Desta forma, o uso adequado dos fertilizantes é uma atividade que deve ser levada em consideração, visando à sustentabilidade econômica, ambiental e social do agronegócio mundial.Nos últimos anos a tecnologia de liberação controlada/modificada tem ganhado destaque, pois ela emergiu como uma importante alternativa capaz de resolver alguns dos problemas que acompanham ...

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Poly(ɛ-caprolactone)nanocapsules as carrier systems for herbicides: Physico-chemical characterization and genotoxicity evaluation

Cited by 204 publications

References 38 publications

Superparamagnetic maghemite loaded poly (ε- caprolactone) nanocapsules : characterization and synthesis optimization

Superparamagnetic maghemite loaded poly (ε- caprolactone) nanocapsules : characterization and synthesis optimization

Polysaccharides as safer release systems for agrochemicals

Otimização multivariada de metodologia para digestão de micropartículas poliméricas carreadoras de cátions metálicos

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