Poly(d,l-lactic acid)-glycerol-based nanoparticles for curcumin delivery

Yoon, In‐Soo; Park, Ju-Hwan; Kang, Hyo Jin; Choe, Ji Hyeong; Goh, Min Su; Kim, Dae‐Duk; Cho, Hyun‐Jong

doi:10.1016/j.ijpharm.2015.04.046

Cited by 38 publications

(41 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Blank and drug-loaded NLCs were stable up to 24 h without any significant size, PDI or EE changes. The mean diameters of all kinds of NLCs in serum remained at around 100 nm making them suitable for an efficient tumor targeting following intravenous administration (Yoon et al, 2015). The size distribution after 24 h of incubation was similar to the initial measurement.…”

Section: Serum Stabilitysupporting

confidence: 61%

Targeted delivery of etoposide to cancer cells by folate-modified nanostructured lipid drug delivery system

Zhang

Zhang³

et al. 2016

Drug Delivery

View full text Add to dashboard Cite

Context: Cardiotoxicity and myelosuppression of etoposide (ETP) limited its clinical application. Targeted drug delivery system could deliver anticancer agents to the target cancerous cells, thus reducing their toxicity. Objective: In this study, folate (FA) was applied for the construction of nanostructured lipid carriers (NLCs), and used for targeted delivery of ETP to tumors overexpresses the FA receptors. Methods: FA-poly (ethylene glycol)-distearoylphosphatidylethanolamine was synthesized. FA decorated and ETP-loaded NLCs (FA-ETP-NLCs) were prepared and the formulation was optimized by Box-Behnken design. Their particle size (PS), zeta potential and drug encapsulation efficiency (EE) was evaluated. In vitro cytotoxicity studies of FA-ETP-NLCs were tested in CT26, SGC7901, NCI-H209 cell lines. In vivo antitumor efficacies of the carriers were evaluated on mice bearing CT26 cells xenografts. Results: The optimum FA-ETP-NLCs formulations had a PS of 120.86 nm. The growth of CT26, SGC790 or NCI-H209 cells in vitro was obviously inhibited. FA-ETP-NLCs also displayed the best antitumor activity than other formulations in vivo. Conclusion: The results demonstrated that FA-ETP-NLCs were efficient in selective delivery to CT26, SGC790 or NCI-H209 cells overexpressing the FA receptors. Also, FA-ETP-NLCs can sufficiently transfer ETP to the cancer cells, enhance the antitumor capacity. Thus, FA-ETP-NLCs could prove to be a superior nanomedicine to achieve tumor therapeutic efficacy.

show abstract

Section: Serum Stabilitysupporting

confidence: 61%

Targeted delivery of etoposide to cancer cells by folate-modified nanostructured lipid drug delivery system

Zhang

Zhang³

et al. 2016

Drug Delivery

View full text Add to dashboard Cite

show abstract

“…For 1 H-NMR (500 MHz) analysis, PLGA-C was solubilized in deuterated chloroform (CDCl3). 6 CUR-loaded PLGA and PLGA-C NPs were fabricated using a modified emulsificationsolvent evaporation method (Lee et al, 2014;Yoon et al, 2015). In brief, PLGA or PLGA-C (40 mg) and CUR (4 mg) were solubilized in dichloromethane (1 mL), and that polymer/drug solution was added to 8 mL PVA solution (2%, w/v).…”

Section: Preparation and Characterization Of Cur-loaded Npsmentioning

confidence: 99%

“…Among them, poly(lactide-co-glycolide) (PLGA) has been regarded as one of biocompatible and biodegradable materials Danhier et al, 2012). Besides PLGA itself, a number of PLGA derivatives have been investigated to prepare nano-sized drug delivery systems (Dhar et al, 2008;Yoon et al, 2015). In this study, poly(lactide-coglycolide)-cholesterol (PLGA-C) has been introduced to fabricate nanoparticles (NPs) for tumor-targeted drug delivery and cancer imaging for the first time.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cholesterol-modified poly(lactide-co-glycolide) nanoparticles for tumor-targeted drug delivery

Lee

Park

et al. 2016

International Journal of Pharmaceutics

Self Cite

View full text Add to dashboard Cite

“…13 In order to control drug release, biomaterials are introduced to prepare polymeric nanoplatfoms. [14][15][16] However, synthetic polymers may induce biocompatibility concerns. Natural silk is a type of fiber polymer which consists of glue-like silk sericin covering silk fibroin (SF).…”

mentioning

confidence: 99%

Supercritical carbon dioxide-developed silk fibroin nanoplatform for smart colon cancer therapy

Xie¹,

Fan²,

Li³

et al. 2017

IJN

View full text Add to dashboard Cite

Purpose To deliver insoluble natural compounds into colon cancer cells in a controlled fashion. Materials and methods Curcumin (CM)–silk fibroin (SF) nanoparticles (NPs) were prepared by solution-enhanced dispersion by supercritical CO 2 (SEDS) (20 MPa pressure, 1:2 CM:SF ratio, 1% concentration), and their physicochemical properties, intracellular uptake efficiency, in vitro anticancer effect, toxicity, and mechanisms were evaluated and analyzed. Results CM-SF NPs (<100 nm) with controllable particle size were prepared by SEDS. CM-SF NPs had a time-dependent intracellular uptake ability, which led to an improved inhibition effect on colon cancer cells. Interestingly, the anticancer effect of CM-SF NPs was improved, while the side effect on normal human colon mucosal epithelial cells was reduced by a concentration of ~10 μg/mL. The anticancer mechanism involves cell-cycle arrest in the G 0 /G 1 and G 2 /M phases in association with inducing apoptotic cells. Conclusion The natural compound-loaded SF nanoplatform prepared by SEDS indicates promising colon cancer-therapy potential.

show abstract

Poly(d,l-lactic acid)-glycerol-based nanoparticles for curcumin delivery

Cited by 38 publications

References 40 publications

Targeted delivery of etoposide to cancer cells by folate-modified nanostructured lipid drug delivery system

Targeted delivery of etoposide to cancer cells by folate-modified nanostructured lipid drug delivery system

Cholesterol-modified poly(lactide-co-glycolide) nanoparticles for tumor-targeted drug delivery

Supercritical carbon dioxide-developed silk fibroin nanoplatform for smart colon cancer therapy

Contact Info

Product

Resources

About