Poly(cyclooctene)-based monolithic columns for capillary high performance liquid chromatography prepared via ring-opening metathesis polymerization

Schlemmer, Bettina; Gatschelhofer, Christina; Pieber, Thomas R.; Sinner, Frank; Buchmeiser, Michael R.

doi:10.1016/j.chroma.2006.07.058

Cited by 35 publications

(26 citation statements)

References 33 publications

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“…Buchmeiser and coworkers first developed various organic monolithic columns with inner diameter ranging from 50 m to 5 cm via ringopening metathesis polymerization for HPLC and CLC [87]. They also prepared the hybrid monolithic columns via ROMP by using cis-cyclooctene (COE), tris(cyclooct-4-enyl-1-oxy)methylsilane as monomers, 2-propanol and toluene as porogens, and RuCl 2 (Py) 2 (IMesH 2 )(CHC 6 H 5 ) (Py = pyridine, IMesH 2 = 1,3-dimesityl-4,5-dihydroimidazolin-2-ylidene) as initiator within the confines of 200 m id fused-silica capillary [87]. Recently, 5-norborn-2-enemethyl bromide (NBE-CH 2 Br) and tris(5-norborn-2-enemethoxy)methylsilane ((NBE-CH 2 O) 3 SiCH 3 ) (Fig.…”

Section: Other Polymerization Approaches Of Monomers Containing Silanesmentioning

confidence: 99%

Recent advances in preparation and application of hybrid organic‐silica monolithic capillary columns

Lin

Zhang

et al. 2012

Electrophoresis

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Hybrid organic-silica monolithic columns, regarded as a second generation of silica-based monoliths, have received much interest due to their unique properties over the pure silicabased monoliths. This review mainly focuses on development in the fields of preparation of hybrid monolithic columns in a capillary and their application for CEC and capillary liquid chromatography separation, as well as for sample pretreatment of solid-phase microextraction and immobilized enzyme reactor since July 2010. The preparation approaches are comprehensively summarized with three routes: (i) general sol-gel process using trialkoxysilanes and tetraalkoxysilanes as coprecursors; (ii) "one-pot" process of alkoxysilanes and organic monomers concomitantly proceeding sol-gel chemistry and free radical polymerization; and (iii) other polymerization approaches of organic monomers containing silanes. The modification of hybrid monoliths containing reactive groups to acquire the desired surface functionality is also described.

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Section: Other Polymerization Approaches Of Monomers Containing Silanesmentioning

confidence: 99%

Recent advances in preparation and application of hybrid organic‐silica monolithic capillary columns

Lin

Zhang

et al. 2012

Electrophoresis

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“…With the aid of such a column, proteins were separated for the first time at neutral pH by RP-CEC. Furthermore, Schlemmer et al [15] prepared monolithic columns for capillary HPLC via ringopening metathesis polymerization (ROMP) with ciscyclooctene (COE) and tris(cyclooct-4-enyl-1-oxy)methylsilane (CL) as monomers, 2-propanol and toluene as porogens, and RuCl 2 (Py) 2 (IMesH 2 )(CHC 6 H 5 ) (Py = pyridine, IMesH2 = 1,3-dimesityl-4,5-dihydroimidazolin-2-ylidene) as the initiator. With such a column, a mixture of six standard proteins, including ribonuclease A, insulin, albumin, lysozyme, myoglobin, and b-lactoglobulin, was separated successfully with a relative standard deviation (RSD) in retention times (t R ) ranging from 2.9 to 3.9%.…”

Section: Monoliths For Reversed Phase Chromatographymentioning

confidence: 97%

Recent development of monolithic materials as matrices in microcolumn separation systems

Zhu

Zhang²,

Yuan

et al. 2007

J of Separation Science

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This review summarizes the development of monolithic materials, including both organic and inorganic polymers, according mainly to the papers published in the past two years. Due to their good permeability, fast mass transfer, high stability, and their ease of modification, such materials have been widely used in microcolumn separation systems, not only as stationary phases for CEC and capillary HPLC, but also as substances for sample concentration and enzyme reactor. All the research results demonstrate that monolithic materials in microseparation systems can be expected to play an increasingly important role in the analysis of complex samples.

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“…COE-based supports have a backbone structure with sec-allylic carbons, which have a higher oxidative stability than NBE-based monoliths with tert-allylic carbons. [17,26] Although the "living" nature of the polymer chains allows for greater reproducibility, the same basic principles that govern the pore sizes of free-radicalpolymerized monoliths also govern pore sizes in ROMP-based monoliths. Increasing the temperature leads to smaller pore sizes, and the ROMP monoliths are typically synthesized around 0 8C.…”

Section: Nbe-and Cis-coe-based Systemsmentioning

confidence: 98%

Catalysts Immobilized on Organic Polymeric Monolithic Supports: From Molecular Heterogeneous Catalysis to Biocatalysis

Anderson

Buchmeiser

2011

ChemCatChem

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This review describes the synthetic routes to various types of organic polymeric monoliths. Significant concentration is applied to the role of these continuous, porous structures in both heterogeneous catalysis and biocatalysis. A monolith is composed of a solitary mass filled with interconnected pores, which include both large flow‐through pores and smaller meso‐ or micropores. These porous monolithic materials have several advantages over conventional packed beds of porous polymeric beads, owing to their macroporosity and lack of interstitial spacing. Their large pores contribute to mass transfer, which allows the structure to withstand higher back pressures than conventional packed beds, whereas their small pores still operate by diffusion. The effect of multiple parameters, such as the temperature, the cross‐link density, and the type and content of porogenic solvent on the pore formation and pore size distribution is outlined for monoliths prepared through free radical polymerization and ring‐opening metathesis polymerization (ROMP). Post‐functionalization of these monoliths to control the surface chemistry of the supports and/or affix functional catalysts is elucidated, as well as employment of these supports in continuous catalytic reactions. Significant advances in supported catalysis for metathesis, Heck, Suzuki, Sonogashira–Hagihara, and biocatalytic reactions are described.

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Poly(cyclooctene)-based monolithic columns for capillary high performance liquid chromatography prepared via ring-opening metathesis polymerization

Cited by 35 publications

References 33 publications

Recent advances in preparation and application of hybrid organic‐silica monolithic capillary columns

Recent advances in preparation and application of hybrid organic‐silica monolithic capillary columns

Recent development of monolithic materials as matrices in microcolumn separation systems

Catalysts Immobilized on Organic Polymeric Monolithic Supports: From Molecular Heterogeneous Catalysis to Biocatalysis

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