Poly (∊-caprolactone) Fiber: An Overview

Azimi, Bahareh; Nourpanah, Parviz; Rabiee, Mohammad; Arbab, Shahram

doi:10.1177/155892501400900309

Cited by 119 publications

(108 citation statements)

References 115 publications

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“…The function of the polymer-film filter is to cool the aerosol,3 thus, it would seem that the polymer composing the film should be heat resistant, although, ε-caprolactone, also known as polycaprolactone, tends to have a low-melting point which is thickness dependent 24. The intensity of the heat produced by the iQOS, under both cleaned and uncleaned conditions, was sufficient to melt the polymer-film filter, even though it was not in direct contact with the heater.…”

Section: Discussionmentioning

confidence: 99%

iQOS: evidence of pyrolysis and release of a toxicant from plastic

2018

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ObjectiveTo evaluate performance of the I quit original smoking (iQOS) heat-not-burn system as a function of cleaning and puffing topography, investigate the validity of manufacturer’s claims that this device does not burn tobacco and determine if the polymer-film filter is potentially harmful.MethodsiQOS performance was evaluated using five running conditions incorporating two different cleaning protocols. Heatsticks were visually and stereomicroscopically inspected preuse and postuse to determine the extent of tobacco plug charring (from pyrolysis) and polymer-film filter melting, and to elucidate the effects of cleaning on charring. Gas chromatography–mass spectrometry headspace analysis was conducted on unused polymer-film filters to determine if potentially toxic chemicals are emitted from the filter during heating.ResultsFor all testing protocols, pressure drop decreased as puff number increased. Changes in testing protocols did not affect aerosol density. Charring due to pyrolysis (a form of organic matter thermochemical decomposition) was observed in the tobacco plug after use. When the manufacturer’s cleaning instructions were followed, both charring of the tobacco plug and melting of the polymer-film filter increased. Headspace analysis of the polymer-film filter revealed the release of formaldehyde cyanohydrin at 90°C, which is well below the maximum temperature reached during normal usage.DiscussionDevice usage limitations may contribute to decreases in interpuff intervals, potentially increasing user’s intake of nicotine and other harmful chemicals. This study found that the tobacco plug does char and that charring increases when the device is not cleaned between heatsticks. Release of formaldehyde cyanohydrin is a concern as it is highly toxic at very low concentrations.

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Section: Discussionmentioning

confidence: 99%

iQOS: evidence of pyrolysis and release of a toxicant from plastic

2018

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“…Azimi et. al .produced gelatin nanoparticles using one and two‐step desolvation method and studied the in vitro release of bovine serum albumin (BSA) concluding a sustained and prolonged release of protein drugs by the system . Coester et.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Investigation of Controlled Release of Ciprofloxacin and Its β‐Cyclodextrin Inclusion Complex from Gelatin Grafted Poly(vinyl alcohol) (GPVA) Nanoparticles

2019

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Controlled drug delivery is one of the probable answers to different problems associated with conventional dosing regimens. Ciprofloxacin (CFX) is an antibiotic, signifying second generation fluoroquinolone which is active against wide‐ranges of microbes. Due to low solubility and bioavailability, it requires a controlled release device for its delivery. An attempt has been made in the present work to develop gelatin grafted poly (vinyl alcohol) (GPVA) hydrogel nanoparticle and study the release behaviour of CFX when incorporated as β‐cyclodextrin CFX inclusion complex and pure CFX. GPVA hydrogel nanoparticles were prepared using two‐step desolvation method and characterized using FTIR, DLS, SEM, and XRD. The in‐vitrorelease at different physiological pH 1.2, 6.8 and 7.4 showed a controlled release of drug from the system when gelatin is grafted with PVA and when an inclusion complex of the drug is introduced in the polymer system. The release kinetic followed zero order with non Fickian Super case II transport mechanism.

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“…Many efforts have been employed to develop starch-based polymers for conserving the petrochemical resources, reducing environmental impacts and searching more applications [25–27]. On the other hand, PCL poly (ε-caprolactone) or simply polycaprolactone is synthetic biodegradable aliphatic polyester which has attracted considerable attention in recent years, particularly in the biomedical applications [28]. A number of polymers have been worked for their compatibility to modify the thermal, rheological as well as biophysical properties of PCL, based on its application [29–36].…”

Section: Introductionmentioning

confidence: 99%

Starch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications

et al. 2017

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BackgroundIn this study, starch and polycaprolactone (PCL), composite nanofibers were fabricated by co-axial needle electrospinning technique. Processing parameters such as polymer concentration, flow rate and voltage had a marked influence on the composite fiber diameter. Fourier transform infrared spectroscopy, scanning electron microscopy (SEM), mechanical and physical properties (such as density, viscosity and electrical conductivity) of the composite fibres were evaluated. Moreover, a cell culture test was performed in order to determine their cytotoxicity for wound dressing application.ResultsThe effect of starch ratio in the solution on the properties and morphological structure of the fibers produced was presented. With lower starch concentration values, the fibers have greater ultimate tensile strength characteristic (mostly 4 and 5 wt%). According to SEM results, it can be figured out that the nanofibers fabricated have good spinnability and morphology. The mean diameter of the fibers is about 150 nm. According to results of cell culture study, the finding can be determined that the increase of starch in the fiber also increases the cell viability.ConclusionsComposite nanofibers of starch/PCL have been prepared using a co-axial needle electrospinning technique. PCL was successfully encapsulated within starch. Fiber formation was observed for different ratio of starch. With several test, analysis and measurement performed, some important parameters such as quality and effectuality of each fiber obtained for wound dressing applications were discussed in detail.

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Poly (∊-caprolactone) Fiber: An Overview

Cited by 119 publications

References 115 publications

iQOS: evidence of pyrolysis and release of a toxicant from plastic

iQOS: evidence of pyrolysis and release of a toxicant from plastic

In Vitro Investigation of Controlled Release of Ciprofloxacin and Its β‐Cyclodextrin Inclusion Complex from Gelatin Grafted Poly(vinyl alcohol) (GPVA) Nanoparticles

Starch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications

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