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Controlled drug delivery is one of the probable answers to different problems associated with conventional dosing regimens. Ciprofloxacin (CFX) is an antibiotic, signifying second generation fluoroquinolone which is active against wide‐ranges of microbes. Due to low solubility and bioavailability, it requires a controlled release device for its delivery. An attempt has been made in the present work to develop gelatin grafted poly (vinyl alcohol) (GPVA) hydrogel nanoparticle and study the release behaviour of CFX when incorporated as β‐cyclodextrin CFX inclusion complex and pure CFX. GPVA hydrogel nanoparticles were prepared using two‐step desolvation method and characterized using FTIR, DLS, SEM, and XRD. The in‐vitrorelease at different physiological pH 1.2, 6.8 and 7.4 showed a controlled release of drug from the system when gelatin is grafted with PVA and when an inclusion complex of the drug is introduced in the polymer system. The release kinetic followed zero order with non Fickian Super case II transport mechanism.