Poly(amino ester)‐Based Polymers for Gene and Drug Delivery Systems and Further Application toward Cell Culture System

Abstract

Various synthetic polymers based on poly(amino ester) (PAE) are suggested as candidates for gene and drug delivery owing to their pH‐responsiveness, which contributes to efficient delivery performance. PAE‐based pH‐responsive polymers are more biodegradable and hydrophilic than other types of pH‐responsive polymers. The functionality of PAE‐based polymers can be reinforced by using different chemical modifications to improve the efficiency of gene and drug delivery. Additionally, PAE‐based polymers are used in many ways in the biomedical field, such as in transdermal delivery and stem cell culture systems. Here, the recent novel PAE‐based polymers designed for gene and drug delivery systems along with their further applications toward adult stem cell culture systems are reviewed. The synthetic tactics are contemplated and pros and cons of each type of polymer are analyzed, and detailed examples of the different types are analyzed.

Efficient Delivery of Globotriaosylceramide Synthase siRNA using Polyhistidine‐Incorporated Lipid Nanoparticles

“…[14,17] In addition, polymeric carriers modified with tertiary amine groups with pK a ≈6.2 exhibited excellent siRNA and gene delivery efficiency. [18,19] The pHis is a polypeptide (pK a of histidine: 6.0-6.4) biodegradable by peptidases in the cytoplasm. [20,21] Considering that the endosomal pH is ≈6.0, the pK a value of ionizable lipids seems to be crucial for endosome escape and siRNA encapsulation.…”