Poly(amidoamine)-modified mesoporous silica nanoparticles as a mucoadhesive drug delivery system for potential bladder cancer therapy

Wang, Beilei; Zhang, Kebiao; Wang, Jiadong; Zhao, Ruibo; Zhang, Quan; Kong, Xiangdong

doi:10.1016/j.colsurfb.2020.110832

Cited by 65 publications

(46 citation statements)

References 43 publications

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“…These released components could synergistically promote the adhesion, proliferation, migration, and angiogenetic differentiation of HUVECs at the wound sites, thereby accelerating wound healing. Following the same concepts, various types of MSNs [214,215], such as MSN@CS-HCA developed by [216], tannic acid (TA)-loaded MSNs by [217], and GQDs@HMSN(EM) by Wang et al (2020) [218], have been synthesized for a similar purpose of accelerating wound healing.…”

Section: Msn Application In Wound Healing and Antibacterial Effectsmentioning

confidence: 99%

“…These characteristics affect the particles’ behavior under biological conditions such as dissolution, drug load, and target delivery [ 29 ]. One of the remarkable features of MSNs is the presence of both internal and external surfaces, serving as a platform for various modifications, which ultimately determine its therapeutic performance, such as controlled release and targeted delivery of drugs [ 91 , 92 , 93 ]. Customizing MSNs by conjugating organic and inorganic compounds is a prerequisite for acquiring multifunctional property and can be achieved through two main approaches: co-condensation and post-synthetic modification [ 58 , 59 , 75 , 94 ].…”

Section: The Fundamentals Of Msn-based Drug Deliverymentioning

confidence: 99%

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An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

et al. 2021

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The efficient and safe delivery of therapeutic drugs, proteins, and nucleic acids are essential for meaningful therapeutic benefits. The field of nanomedicine shows promising implications in the development of therapeutics by delivering diagnostic and therapeutic compounds. Nanomedicine development has led to significant advances in the design and engineering of nanocarrier systems with supra-molecular structures. Smart mesoporous silica nanoparticles (MSNs), with excellent biocompatibility, tunable physicochemical properties, and site-specific functionalization, offer efficient and high loading capacity as well as robust and targeted delivery of a variety of payloads in a controlled fashion. Such unique nanocarriers should have great potential for challenging biomedical applications, such as tissue engineering, bioimaging techniques, stem cell research, and cancer therapies. However, in vivo applications of these nanocarriers should be further validated before clinical translation. To this end, this review begins with a brief introduction of MSNs properties, targeted drug delivery, and controlled release with a particular emphasis on their most recent diagnostic and therapeutic applications.

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Section: Msn Application In Wound Healing and Antibacterial Effectsmentioning

confidence: 99%

Section: The Fundamentals Of Msn-based Drug Deliverymentioning

confidence: 99%

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

et al. 2021

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“…that facilitate their application in industry and medicine. For example, in [227] MSNs were modified by poly(amido)amine dendrimers (PAMAM) of the first and second generations for imparting mucoadhesive properties to the carrier. Bioadhesion of these polymers was caused by electrostatic interactions between positively charged dendrimers and negatively charged mucin of urothelium.…”

Section: Mesoporous Silica Nanoparticles Modified By Synthetic Polymersmentioning

confidence: 99%

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Kashapov

Ibragimova

Pavlov

et al. 2021

IJMS

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Encapsulation of cargoes in nanocontainers is widely used in different fields to solve the problems of their solubility, homogeneity, stability, protection from unwanted chemical and biological destructive effects, and functional activity improvement. This approach is of special importance in biomedicine, since this makes it possible to reduce the limitations of drug delivery related to the toxicity and side effects of therapeutics, their low bioavailability and biocompatibility. This review highlights current progress in the use of lipid systems to deliver active substances to the human body. Various lipid compositions modified with amphiphilic open-chain and macrocyclic compounds, peptide molecules and alternative target ligands are discussed. Liposome modification also evolves by creating new hybrid structures consisting of organic and inorganic parts. Such nanohybrid platforms include cerasomes, which are considered as alternative nanocarriers allowing to reduce inherent limitations of lipid nanoparticles. Compositions based on mesoporous silica are beginning to acquire no less relevance due to their unique features, such as advanced porous properties, well-proven drug delivery efficiency and their versatility for creating highly efficient nanomaterials. The types of silica nanoparticles, their efficacy in biomedical applications and hybrid inorganic-polymer platforms are the subject of discussion in this review, with current challenges emphasized.

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“…Samanta et al have followed a similar approach of exploiting lipid bilayer around MSN to assist folate receptor targeted drug delivery in ovarian cancer [ 301 ]. Several other efforts have also been reported, exploiting organic/inorganic hybrid nanocarriers, L-tartaric acid, mucoadhesive delivery systems, organosilica-based drug delivery systems, to improve the biocompatibility of MSN [ 302 , 303 , 304 , 305 ]. Besides, cancer cell membranes have been utilized to coat MSN to improve immunocompatibility [ 306 , 307 ].…”

Section: Challenges Regarding Msn Application In Cancer Therapymentioning

confidence: 99%

Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy

Barui

Cauda

2020

Pharmaceutics

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The presence of leaky vasculature and the lack of lymphatic drainage of small structures by the solid tumors formulate nanoparticles as promising delivery vehicles in cancer therapy. In particular, among various nanoparticles, the mesoporous silica nanoparticles (MSN) exhibit numerous outstanding features, including mechanical thermal and chemical stability, huge surface area and ordered porous interior to store different anti-cancer therapeutics with high loading capacity and tunable release mechanisms. Furthermore, one can easily decorate the surface of MSN by attaching ligands for active targeting specifically to the cancer region exploiting overexpressed receptors. The controlled release of drugs to the disease site without any leakage to healthy tissues can be achieved by employing environment responsive gatekeepers for the end-capping of MSN. To achieve precise cancer chemotherapy, the most desired delivery system should possess high loading efficiency, site-specificity and capacity of controlled release. In this review we will focus on multimodal decorations of MSN, which is the most demanding ongoing approach related to MSN application in cancer therapy. Herein, we will report about the recently tried efforts for multimodal modifications of MSN, exploiting both the active targeting and stimuli responsive behavior simultaneously, along with individual targeted delivery and stimuli responsive cancer therapy using MSN.

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Poly(amidoamine)-modified mesoporous silica nanoparticles as a mucoadhesive drug delivery system for potential bladder cancer therapy

Cited by 65 publications

References 43 publications

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy

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