Poly[3-(3,4-dihydroxyphenyl)glyceric Acid] from <i>Anchusa italica</i> Roots

Barbakadze, Vakhtang; Gogilashvili, Lali; Amiranashvili, Lela; Merlani, Maia; Mulkijanyan, Karen; Churadze, Manana; Salgado, Antonio; Chankvetadze, Bezhan

doi:10.1177/1934578x1000500722

Cited by 9 publications

(13 citation statements)

References 23 publications

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“…Five species of genus Anchusa have been found in Iran (Mozaffarian, 1996;Kazemi, 2013). A. italica has been demonstrated to contain alkaloids, tannins, saponins, triterpenes, and polyphenols such as anthocyanins and flavonoids (Barbakadze et al, 2010). In traditional medicine, A. italica extract is used as a stimulant, tonic, palliative in biliary diseases, diuretic, sedative, antiarthritic, anti-asthma, and laxative.…”

Section: Introductionmentioning

confidence: 99%

Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion

Torki

Khalaji-Pirbalouty

Lorigooini

et al. 2018

Braz. J. Pharm. Sci.

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Stroke is the third leading cause of mortality and disability in industrial countries. Treatment with herbs with antioxidant properties has been reported to be an alternative to the conventional treatments. This study was conducted to investigate the effect of Anchusa italica extract on hippocampal injury induced by transient global cerebral ischemia and reperfusion in the rat. To do so, 50 rats were randomly assigned to five groups; control, sham, ischemia, and 50 or 100 mg/kg of Anchusa italica treated animals. Ischemia was induced by occlusion of carotid artery for 30 minutes. Afterward, behavioral tests and biochemical analyses were conducted. Induction of ischemia/reperfusion caused a decline in learning and passive avoidance memory in rats. Moreover, Anchusa italica caused an increase in learning and improved the passive avoidance memory. Induction of ischemia/reperfusion caused a decrease in the antioxidant capacity of the brain and serum as well as an increase in the malondialdehyde of the brain and serum. Anchusa italica led to an increase in the antioxidant capacity of the brain and serum and decrease in the malondialdehyde of the brain and serum. Overall, because of its protective effects on spatial memory, passive avoidance learning, antioxidant capacity, and lipid peroxidation during ischemia/reperfusion, Anchusa italica might be beneficial in ischemic patients.

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Section: Introductionmentioning

confidence: 99%

Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion

Torki

Khalaji-Pirbalouty

Lorigooini

et al. 2018

Braz. J. Pharm. Sci.

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“…The intensive survey revealed no reported chemical information for three species, namely, A. palestina , H. ledifolium , and O. giganteum whereas only poly[3-(3,4-dihydroxyphenyl)glyceric acid and some alkaloids were reported from A. italica . [ 39 40 ] Phenolics of classes flavonoids, coumarins, simple phenols (e.g., thymol and eugenol), and their derivatives were reported to occur in various extracts and volatile oils obtained from O. natrix . [ 41 – 43 ] Volatile oil was the main fraction studied for A. biebersteinii ; 1,8-cineole and camphor were the major oxygenated oil components reported in various studies.…”

Section: Resultsmentioning

confidence: 99%

Xanthine oxidase inhibitory activity of the methanolic extracts of selected Jordanian medicinal plants

et al. 2011

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Background:The search for novel xanthine oxidase (XO) inhibitors with a higher therapeutic activity and fewer side effects are desired not only to treat gout but also to combat various other diseases associated with the XO activity. At present, the potential of developing successful natural products for the management of XO-related diseases is still largely unexplored. In the present study, we have screened the methanolic extracts of various Jordanian medicinal plants for their XO inhibitory activities using an optimized protocol.Materials and Methods:The methanolic extracts of 23 medicinal plants, belonging to 12 families, were tested in vitro, at 200 μg/ml concentrations, for their XO inhibitory potential. The dose-dependent inhibition profiles of the most active plants were further evaluated by estimating the IC50 values of their corresponding extracts.Results:Six plants were found most active (% inhibition more than 39%). These plants are Salvia spinosa L. (IC50 = 53.7 μg/ml), Anthemis palestina Boiss. (168.0 μg/ml), Chrysanthemum coronarium L. (199.5 μg/ml), Achillea biebersteinii Afansiev (360.0 μg/ml), Rosmarinus officinalis L. (650.0 μg/ml), and Ginkgo biloba L. (595.8 μg/ml). Moreover, four more plants, namely Lavandula angustifolia Mill. (28.7% inhibition), Helianthemum ledifolium (L.) Mill. (28.4%), Majorana syriaca (L.) Kostel. (25.1%), and Mentha spicata L. (22.5%) showed a XO inhibitory activity in the range of 22–30%.Conclusion:The study showed that many of the tested plant species are potential sources of natural XO inhibitors that can be developed, upon further investigation, into successful herbal drugs for treatment of gout and other XO-related disorders.

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“…We have recently reported the synthesis and cationic polymerization of 2‐methoxycarbonyl‐3‐(3,4‐dimethoxyphenyl)oxirane (MDMPO) as an unsymmetrically 2,3‐disubstituted oxirane monomer 3. Poly(MDMPO) was designed on the basis of poly[2‐hydroxycarbonyl‐3‐(3,4‐dimethoxyphenyl)oxirane] (poly[3‐(3,4‐dihydroxyphenyl)glyceric acid]) which is proposed to be an important ingredient contained in folk medicines widely used in southern European countries. In spite of the bulky structure, MDMPO was found to yield a polyether, and the resulting polymer had a rather stiff conformation leading to intramolecular charge transfer (ICT) interactions.…”

Section: Introductionmentioning

confidence: 99%

Polymerization of Bulky of Oxirane Monomers Leading to Polyethers Exhibiting Intramolecular Charge Transfer Interactions

Merlani

Song

Wang

et al. 2019

Macro Chemistry & Physics

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Three novel oxirane monomers, 2‐methoxycarbonyl‐3‐(3,4‐dibenzyloxyphenyl)oxirane (MDBPO), 2‐benzyloxycarbonyl‐3‐(3,4‐dibenzyloxyphenyl)oxirane (BDBPO), and 2‐t‐butyloxycarbonyl‐3‐(3,4‐dibenzyloxyphenyl)oxirane (TBDBPO) are prepared and polymerized using BF3‐OEt2 in CH2Cl2 to yield polyethers. The monomers smoothly lead to polymers under the cationic conditions in spite of the monomers' rather bulky structures. The obtained polymers exhibit characteristic UV spectra with intramolecular charge transfer (ICT) bands through hetero π‐stacked structure formed between the side‐chain carbonyl group and the phenyl group directly connects to the main chain. The relative intensity of the ICT bands is the strongest for poly(TBDBPO) having bulky t‐butyl ester group. This spectral feature is considered to have connection with rigidity of polymer chain. Poly(TBDBPO) having the bulkiest side‐chain group is considered to possess the most rigid chain conformation that can account for its strongest ICT interactions that may occur between the carbonyl group and the phenyl group directly attached to the main chain. The proposed rigid chain conformation of poly(TBDBPO) is supported by the fact that the polymer does not show clear Tg while the other two polymers do.

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Poly[3-(3,4-dihydroxyphenyl)glyceric Acid] from Anchusa italica Roots

Cited by 9 publications

References 23 publications

Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion

Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion

Xanthine oxidase inhibitory activity of the methanolic extracts of selected Jordanian medicinal plants

Polymerization of Bulky of Oxirane Monomers Leading to Polyethers Exhibiting Intramolecular Charge Transfer Interactions

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