Poly(2-oxazoline) functionalized surfaces: from modification to application

Tauhardt, Lutz; Kempe, Kristian; Gottschaldt, Michael; Schubert, Ulrich S.

doi:10.1039/c3cs60161g

Cited by 131 publications

(96 citation statements)

References 49 publications

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“…[21][22][23][24][25] POxs have generated considerable interest in part because they are able to maintain their antifouling character for longer periods than PEG, suffering less oxidative damage in biological and oxidative media. [21][22][23][24][25] POxs have generated considerable interest in part because they are able to maintain their antifouling character for longer periods than PEG, suffering less oxidative damage in biological and oxidative media.…”

Section: Poly(2-oxazoline)smentioning

confidence: 99%

Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates

2015

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Nonspecific protein adsorption and/or microbial adsorption on biomedical materials adversely affects the efficacy of a range of biomedical systems, from implants and biosensors to nanoparticles. To address this problem, antibiofouling polymers can be coated on biomedical devices or built into nanoparticles to confer protein and/or microbial repellent properties. The current review provides an overview of the range of synthetic polymers currently used to this end and explores their biomedical potential. The most widely-used antifouling polymer, poly(ethylene glycol) (PEG) is reviewed alongside several promising alternatives, including zwitterionic polymers, poly(hydroxyfunctional acrylates), poly(2-oxazoline)s, poly (vinylpyrrolidone), poly(glycerol), peptides and peptoids. For each material, notable applications for both nanomedicine and macroscopic surface coatings are highlighted.

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Section: Poly(2-oxazoline)smentioning

confidence: 99%

Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates

2015

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“…However, this difference alone is unlikely to explain the differences in the ability of the polymers to support epithelial cells or fibroblasts in the adhesion, motility and growth assays. Our studies demonstrating that polymer-coated glass substrates support cell adhesion conflict with other studies which have 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 shown that PMeOx-coated surfaces inhibited bacterial binding, so-called anti-fouling behaviour [28]. However, in view of the marked differences in the structural properties of bacterial cell walls and mammalian cell membranes, it is not unreasonable to expect differences in binding.…”

Section: Discussionmentioning

confidence: 70%

Biocompatibility of poly(2-alkyl-2-oxazoline) brush surfaces for adherent lung cell lines

et al. 2015

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Development of synthetic surfaces that are highly reproducible and biocompatible for in vitro cell culture offers potential for development of improved models for studies of cellular physiology and pathology. They may also be useful in tissue engineering by removal of the need for biologically-derived components such as extracellular matrix proteins. We synthesised four types of 2-alkyl-2-oxazoline polymers ranging from the hydrophilic poly(2-methyl-2-oxazoline) to the hydrophobic poly(2-n-butyl-2-oxazoline). The polymers were terminated using amine-functionalised glass coverslips, enabling the synthetic procedure to be reproducible and scaleable. The polymer-coated glass slides were tested for biocompatibility using human epithelial (16HBE 14o-) and fibroblastic (MRC5) cell lines.Differences in adhesion and motility of the two cell types was observed, with the poly(2-isopropyl-2-oxazoline) polymer equally supporting the growth of both cell types, whereas poly(2-n-butyl-2-oxazoline) showed selectivity for fibroblast growth. In summary, 2-alkyl-2-oxazoline polymers may be a useful tool for building in vitro model cell culture models with preferential adhesion of specific cell types.

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“…1c. In order to start the sensitization process, as reported in literature [21][22][23], the fiber tips were then immersed into H 2 SO 4 solution maintaining a constant temperature at 80 • C using a hot plate. After H 2 O 2 was added into the H 2 SO 4 solution with a concentration ratio of H 2 SO 4 :H 2 O 2 = 3:1 (also known as the piranha solution) the fiber tip was kept for another 20 min.…”

Section: Sensitization Of Fiber Tipmentioning

confidence: 99%

Ultrafast FRET at fiber tips: Potential applications in sensitive remote sensing of molecular interaction

Polley

Singh

Giri

et al. 2015

Sensors and Actuators B: Chemical

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Poly(2-oxazoline) functionalized surfaces: from modification to application

Cited by 131 publications

References 49 publications

Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates

Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates

Biocompatibility of poly(2-alkyl-2-oxazoline) brush surfaces for adherent lung cell lines

Ultrafast FRET at fiber tips: Potential applications in sensitive remote sensing of molecular interaction

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