Poloxamer 407 microspheres for orotransmucosal drug delivery. Part II: In vitro/in vivo evaluation

Monti, Daniela; Burgalassi, Susi; Rossato, Maurício; Albertini, Beatrice; Passerini, Nadia; Rodriguez, Lorenzo; Chetoni, Patrizia

doi:10.1016/j.ijpharm.2010.08.018

Cited by 30 publications

(14 citation statements)

References 29 publications

(30 reference statements)

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“…Similar observation was previously reported where PluF-127 micelles improved the effective permeability of paclitaxel through rat small intestine [59]. Surfactants have been shown to increase drug permeability by altering membrane properties, thus allowing drug absorption by passive diffusion through the paracellular pathway [60]. Pluronics were also found to be permeability enhancers acting through inhibition of efflux pumps and lowering membrane fluidity [61].…”

Section: Ex-vivo Permeability Studiessupporting

confidence: 81%

Different Approaches for Enhancement of Curcumin Aqueous Solubility and Dissolution rate

Hassan

El-Mahdy

El-Badry

et al. 2019

Journal of advanced Biomedical and Pharmaceutical Sciences

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Curcumin (CUR) is a nature polyphenolic phytoingredient. CUR showed anti-inflammatory, anti-oxidant, anti-fungal and anticancer activities. The therapeutic efficacy of CUR was limited due to its poor aqueous solubility, poor oral bioavailability. Poor solubility of drugs is the major challenge associated with formulation development. Therefore, the aim of present work was to enhance CUR aqueous solubility and dissolution rate using Physical mixture and its solid dispersion. CUR solid dispersions were prepared by solvent evaporation and Freeze drying techniques using different polymers, such as β-cyclodextrins, polyvinyl pyrrolidone (PVP K30), polyethylene glycol 6000 and Pluronic ® F-127. The prepared physical mixtures, solid dispersions were characterized using different techniques such as (DSC), (FTIR) and (XRD). Furthermore, the solubility and the dissolution rate of the drug in its different systems were explored. The results of physical characterization of the different systems show no interaction between them. Dissolution studies of CUR solid dispersions showed that the highest drug dissolution rate was achieved at CUR/ Pluronic®F-127 weight ratio of 1:3. Also, complete drug dissolution was obtained for CUR/Pluronic F-127 solid dispersion after 30 min compared to 35 % dissolution for CUR alone after the same time. Also, CUR permeability coefficient through rat skin for Pluronic®F-127 micelles and solid dispersion were two times higher than that of the CUR alone. The obtained results concluded that, the preparation of solid dispersion of Pluronic®F-127 solid dispersions by freeze drying method is a promising one to overcome CUR shortcomings through enhancing its aqueous solubility, dissolution rate and skin permeability.

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Section: Ex-vivo Permeability Studiessupporting

confidence: 81%

Different Approaches for Enhancement of Curcumin Aqueous Solubility and Dissolution rate

Hassan

El-Mahdy

El-Badry

et al. 2019

Journal of advanced Biomedical and Pharmaceutical Sciences

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show abstract

“…The microparticles, sublingually administered in rabbits, compared to a market oral tablet, revealed an absolute bioavailability higher than that of reference in spite of a lower dosage of drug [133].…”

Section: Particulate Systemsmentioning

confidence: 84%

A focus on mucoadhesive polymers and their application in buccal dosage forms

Russo

Selmin

Baldassari

et al. 2016

Journal of Drug Delivery Science and Technology

130

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“…These two formulae were selected for this investigation. SLN made of Gelucire50/13 and poloxamer 407 were supposed to have relatively higher adhesion to mucin because of their hydrophilic characters . The test is the first to describe the nanoparticle adhesion in terms of retardation of drug release.…”

Section: Resultsmentioning

confidence: 99%

“…SLN made of Gelucire50/13 and poloxamer 407 were supposed to have relatively higher adhesion to mucin because of their hydrophilic characters. 38,39 The test is the first to describe the nanoparticle adhesion in terms of retardation of drug release. By investigating the adhesion properties of CurSLN to mucin using modified mucin particle method, the results showed that the amount of free drug after 3 h of the experiment from both formulae decreased in the presence of mucin, where Cur recovered from G50/13-PX407 in the presence of mucin was 27% as compared with 39% recovered in the absence of mucin, with a significant difference (p = 0.002), whereas for the formula (G50/13-G50/13), the amount of Cur recovered was 21.84% as compared with 29.4% in the presence and absence of mucin, respectively (Fig.…”

Section: Evaluation Of Mucoadhesive Properties Of Curslnmentioning

confidence: 99%

Gelucire-Based Nanoparticles for Curcumin Targeting to Oral Mucosa: Preparation, Characterization, and Antimicrobial Activity Assessment

Hazzah

Farid

Nasra

et al. 2015

Journal of Pharmaceutical Sciences

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Poloxamer 407 microspheres for orotransmucosal drug delivery. Part II: In vitro/in vivo evaluation

Cited by 30 publications

References 29 publications

Different Approaches for Enhancement of Curcumin Aqueous Solubility and Dissolution rate

Different Approaches for Enhancement of Curcumin Aqueous Solubility and Dissolution rate

A focus on mucoadhesive polymers and their application in buccal dosage forms

Gelucire-Based Nanoparticles for Curcumin Targeting to Oral Mucosa: Preparation, Characterization, and Antimicrobial Activity Assessment

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