Pollutant-sex specific differences in respiratory hospitalization and mortality risk attributable to short-term exposure to ambient air pollution

Shin, Hwashin Hyun; Parajuli, Rajendra Prasad; Gogna, Priyanka; Maquiling, Aubrey; Dehghani, Parvin

doi:10.1016/j.scitotenv.2020.143135

Cited by 21 publications

(13 citation statements)

References 114 publications

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“…We observed that the risk of O 3 on IPF hospitalization was more pronounced in women, in line with studies which generally found women had a higher respiratory hospitalization risk from O 3 exposure, particularly during the cold season [ 33 ]. And for NO 2 effects, we only found significant associations in men.…”

Section: Discussionsupporting

confidence: 90%

“…In addition, O 3 can cause breathing difficulty by bronchoconstriction, thereby increasing the risk of hospitalization among individuals with existing respiratory diseases including IPF [ 32 ]. Animal and human studies have suggested that O 3 can reach and accumulate at the lower lungs because of its low water solubility, leading to inflammation and impaired small airways function, and potential hospitalization risk [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…sex hormones, airway diameter, lung size) and gender-specific (socioeconomic and cultural factors, e.g. occupation, personal activity) differences of air pollution effects on respiratory health outcomes still largely remain inconsistent across studies [ 33 ], and future studies are warranted to gain better insights into these two different pathways.…”

Section: Discussionmentioning

confidence: 99%

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Air pollution and hospitalization of patients with idiopathic pulmonary fibrosis in Beijing: a time-series study

et al. 2022

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Background A small number of studies suggested that air pollution was associated with idiopathic pulmonary fibrosis (IPF) exacerbation, incidence and mortality. However, no studies to date were conducted in regions where air pollution is substantial. We aimed to investigate whether there are associations between acute increases in air pollution and hospitalization of patients with a confirmed primary diagnosis of IPF in Beijing. Methods Daily count of IPF hospitalizations (International Classification of Disease-10th Revision, J84.1) was obtained from an administrative database for 2013–2017 while daily city-wide average concentrations of PM10, PM2.5, NO2, Ozone, SO2 were obtained from 35 municipal monitoring stations for the same period. The association between daily IPF hospitalization and average concentration of each pollutant was analyzed with a generalized additive model estimating Poisson distribution. Results Daily 24-h mean PM2.5 concentration during 2013–2017 was 76.7 μg/m3. The relative risk (RR) of IPF hospitalization per interquartile range (IQR) higher (72 μg/m3) in PM2.5 was 1.049 (95% CI 1.024–1.074) and 1.031 (95% CI 1.007–1.056) for lag0 and moving averages 0–1 days respectively. No significant associations were observed for other lags. Statistically significant positive associations were also observed at lag0 with SO2, Ozone and NO2 (in men only). Positive associations were seen at moving averages 0–30 days for PM10 (RR per 86 μg/m3: 1.021, 95% CI 0.994–1.049), NO2 (RR per 30 μg/m3: 1.029, 95% CI 0.999–1.060), and SO2 (RR per 15 μg/m3: 1.060 (95% CI 1.025–1.097), but not with PM2.5 or Ozone. Conclusions Despite improvement in air quality since the implementation of clean air policy in 2013, acute exposure to higher levels of air pollution is significantly associated with IPF hospitalization in Beijing. Air quality policy should be continuously enforced to protect vulnerable IPF populations as well as the general public.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Air pollution and hospitalization of patients with idiopathic pulmonary fibrosis in Beijing: a time-series study

et al. 2022

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“…We found a larger effect of particulate matter–ALRI association among men than women, which is similar to the results of the sex-specific effects of particulate matter pollution reported previously ( 19 ). This may be due to the biological differences between men and women populations, such as hormones, sizes of airway diameters and lung sizes, and build, which will, in turn, result in the difference in the transport of pollutants and tissue deposition ( 17 , 32 ). In addition, the observed associations between particulate matter and ALRI were stronger during the cold season, which is in line with the several previous studies ( 26 , 33 – 35 ).…”

Section: Discussionmentioning

confidence: 99%

Size-Specific Particulate Matter Associated With Acute Lower Respiratory Infection Outpatient Visits in Children: A Counterfactual Analysis in Guangzhou, China

Liang

Meng

Yang

et al. 2021

Front. Public Health

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The burden of lower respiratory infections is primarily evident in the developing countries. However, the association between size-specific particulate matter and acute lower respiratory infection (ALRI) outpatient visits in the developing countries has been less studied. We obtained data on ALRI outpatient visits (N = 105,639) from a tertiary hospital in Guangzhou, China between 2013 and 2019. Over-dispersed generalized additive Poisson models were employed to evaluate the excess risk (ER) associated with the size-specific particulate matter, such as inhalable particulate matter (PM10), coarse particulate matter (PMc), and fine particulate matter (PM2.5). Counterfactual analyses were used to examine the potential percent reduction of ALRI outpatient visits if the levels of air pollution recommended by the WHO were followed. There were 35,310 pneumonia, 68,218 bronchiolitis, and 2,111 asthma outpatient visits included. Each 10 μg/m3 increase of 3-day moving averages of particulate matter was associated with a significant ER (95% CI) of outpatient visits of pneumonia (PM2.5: 3.71% [2.91, 4.52%]; PMc: 9.19% [6.94, 11.49%]; PM10: 4.36% [3.21, 5.52%]), bronchiolitis (PM2.5: 3.21% [2.49, 3.93%]; PMc: 9.13% [7.09, 11.21%]; PM10: 3.12% [2.10, 4.15%]), and asthma (PM2.5: 3.45% [1.18, 5.78%]; PMc: 11.69% [4.45, 19.43%]; PM10: 3.33% [0.26, 6.49%]). The association between particulate matter and pneumonia outpatient visits was more evident in men patients and in the cold seasons. Counterfactual analyses showed that PM2.5 was associated with a larger potential decline of ALRI outpatient visits compared with PMc and PM10 (pneumonia: 11.07%, 95% CI: [7.99, 14.30%]; bronchiolitis: 6.30% [4.17, 8.53%]; asthma: 8.14% [2.65, 14.33%]) if the air pollutants were diminished to the level of the reference guidelines. In conclusion, short-term exposures to PM2.5, PMc, and PM10 are associated with ALRI outpatient visits, and PM2.5 is associated with the highest potential decline in outpatient visits if it could be reduced to the levels recommended by the WHO.

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“…Elderly individuals, pregnant women and children (discussed later), people with disabilities, and those with chronic medical conditions (including immunodeficiency) are at the highest risk. [112][113][114] Considering the fact that impoverished populations have a higher probability of chronic diseases, exposure to environmental pollution can affect individuals with underlying asthma, COPD, and pulmonary fibrosis 115 differentially, putting them at greater risk of hospitalization 116,117 and mortality, as demonstrated recently in European cities. 118…”

Section: Vulnerable Populationsmentioning

confidence: 99%

Climate change and global issues in allergy and immunology

Pacheco¹,

Guidos

Annesi‐Maesano

et al. 2021

Journal of Allergy and Clinical Immunology

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Pollutant-sex specific differences in respiratory hospitalization and mortality risk attributable to short-term exposure to ambient air pollution

Cited by 21 publications

References 114 publications

Air pollution and hospitalization of patients with idiopathic pulmonary fibrosis in Beijing: a time-series study

Air pollution and hospitalization of patients with idiopathic pulmonary fibrosis in Beijing: a time-series study

Size-Specific Particulate Matter Associated With Acute Lower Respiratory Infection Outpatient Visits in Children: A Counterfactual Analysis in Guangzhou, China

Climate change and global issues in allergy and immunology

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