Polarography of Some Purine Derivatives

Electrochemical Determination of HIV Drug Abacavir Based on Its Reduction

“…The role of covalent hydration may be an important factor resulting in confusion about the number of electrons transferred in the reductions of III and IV in the literature. − Comparison of limiting currents of I , III , and IV in sufficiently acidic solutions with limiting current of equimolar solutions of benzaldehyde, benzoin oxime, and Cd 2+ ions (for which the number of electrons transferred in the reduction process is known) has shown (after correction for the role of hydration) that for all three compounds ( I , III , IV ) there are four electrons transferred in the first reduction process.…”

“…9 To develop an electroanalytical procedure for determination of ABA (I), based on its reduction, its behavior was compared with the reduction of electroreduction of adenine and its phosphate derivatives, the only 6-aminopurines reduced at the dropping mercury electrode (DME). [10][11][12][13][14][15][16][17][18][19][20] Unfortunately, the conclusions about the electrode processes involved in the reduction differed considerably. There was no agreement about the number of electrons transferred in the first reduction step, the number of reduction waves, or the role of pH and the buffer composition.…”

Organic Polarography

“…Data are given for imidazoleacrylic acid (356) , violuric acid and its metal chelates (368), aspergillic acid (95) , quinoxaline (602) , 6-substituted quinoxalines (603), quin-0xaline-2~3-dithiol (638) , 0-and mphenanthrolines (142) , 3-substituted-2thioketo-4-keto-lJ2,3,4,5,6,7,8-octahydroquinazolines (482) , porphyrindin (465) , 8-chlorotheophylline (6S7) , 1,3dimethyl-4-amino-5-nitrosouracil (397) , adenosine, adenylic acid, and related compounds (389) The determination has been used for thiobarbituric acid derivatives and 4methyl-2-thiouracil in pharmaceutical preparations (398), and for adenine in the pancreas (154) and blood (373).…”

“…Polarographic studies of cyclic compounds containing more than one nitrogen atom have been numerous. Data are given for imidazoleacrylic acid (356), violuric acid and its metal chelates (368), aspergillic acid (95), quinoxaline (602), 6-substituted quinoxalines (60S), quinoxaline-2,3-dithiol (598), o-and mphenanthrolines (142), 3-substituted-2thioketo -4 -keto-1,2,3,4,5,6,7,8-octahydroquinazolines (482), porphyrindin (465), 8-chlorotheophylline (637), 1,3dimethyl-4-amino-5-nitrosouracil (397), adenosine, adenylic acid, and related compounds (389).…”

Analytical Utilization of the Polarographic and Voltammetric Behavior of Purines and Pyrimidines.

“…Purine, adenine, and hypoxanthine are reduced only in acidic solution; 2,6-diaminopurine, which has been investigated (13,14) only at low pH, is also likely nonreducible under alkaline conditions. The order of ease of reduction is purine > adenine, 2,6diaminopurine > hypoxanthine.…”