Analytical Utilization of the Polarographic and Voltammetric Behavior of Purines and Pyrimidines.

Smith, David L.; Elving, Philip J.

doi:10.1021/ac60188a017

Cited by 68 publications

(27 citation statements)

References 20 publications

(14 reference statements)

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“…In alkaline conditions, hypoxanthine was not reduced [2]. It was also found that hypoxanthine forms a condensed film at the mercury -electrolyte interface [4].…”

Section: Introductionmentioning

confidence: 93%

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Voltammetric and impedance studies of inosine-5′-monophosphate and hypoxanthine

Oliveira-Brett

Silva

Farace

et al. 2003

Bioelectrochemistry

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The oxidation mechanism and adsorption of inosine 5V -monophosphate and hypoxanthine were investigated in solutions of different pH using voltammetric and impedance methods at glassy carbon electrodes. For both compounds, the pH dependence from differential pulse voltammetry showed that the same number of electrons and protons are involved in the rate-determining step of the electrochemical reaction. In the case of hypoxanthine, it was also possible to study the effect of different concentrations. At high concentrations of hypoxanthine, two oxidation peaks were observed, the first due to hypoxanthine oxidation with formation of oligomers and the second due to hypoxanthine oligomer oxidation, both compounds adsorbing strongly. Impedance measurements corroborated the voltammetric results and enabled the study of the adsorption of hypoxanthine on glassy carbon. D

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“…In alkaline conditions, hypoxanthine was not reduced [2]. It was also found that hypoxanthine forms a condensed film at the mercury -electrolyte interface [4].…”

Section: Introductionmentioning

confidence: 93%

“…Electrochemical studies of the reduction of inosine and hypoxanthine carried out at mercury electrodes showed better defined reduction peak currents in acid pH [2,3]. In alkaline conditions, hypoxanthine was not reduced [2].…”

Section: Introductionmentioning

confidence: 96%

Voltammetric and impedance studies of inosine-5′-monophosphate and hypoxanthine

Oliveira-Brett

Silva

Farace

et al. 2003

Bioelectrochemistry

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“…In addition, the pyrimidine forms sparingly soluble compounds with Hg(II) at the surface of mercury electrode, which allows their determination by cathodic stripping voltammeters [3][4][5][6]. Due to low signal-to-noise ratio and their extreme positive oxidation potentials, thymine and cytosine have been assumed to exhibit no electrochemical activity at graphite electrodes [7,8] or carbon-based electrodes in general [9,10]. Brett reported oxidation of thymine and cytosine at glassy carbon electrode in alkaline pH solution after ultrasonic pretreatment [11].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical methods for determination of thymine in medical pipefish samples based on HPMαFP/Ppy/GCE-modified electrode

Han

et al. 2013

Ionics

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A sensitive electrochemical method was developed for the voltammetric determination of thymine at a composite film-modified electrode 1-phenyl-3-methyl-4-(2-furoyl)-5-pyrazolone (HPMαFP)/polypyrrole (Ppy)/glassy carbon electrode (GCE). The electrochemical parameters of thymine were investigated by cyclic voltammetry and differential pulse voltammetry. In pH=7.4, one sensitive oxidation peak of thymine with E pa =0.968 V was observed on the HPMαFP/PPymodified electrode. The difference of peak potential (ΔE pa ) was 188 mV lower than that for bare GCE. Compared to the bare GCE and Ppy/GCE, the HPMαFP/Ppy/GCE-modified electrode showed an excellent electrocatalytic effect on the oxidation of thymine and displayed a shift of the oxidation potential in the negative direction with significant increase in the peak current. Under the optimum condition, the concentration calibration range and detection limit are 2×10

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“…The DNA backbone is a copolymer of phosphoric acid and 2-deoxyribose, with one of the four bases, adenine (A), guanine (G), cytosine (C) and thymine (T), linked to C-1 of each pentose unit. According to previous literature reports thymine has been assumed to exhibit no electrochemical activity at carbon-based electrode in general [12,13]. However, the application of ultrasound in combination with differential pulse voltammetry results in a reliable analytical procedure for thymine measurements that avoids electrode fouling and maintains the electrode characteristics [14].…”

Section: Introductionmentioning

confidence: 99%

The Electrocatalytic Oxidation of Thymine at α‐Cyclodextrin Incorporated Carbon Nanotube‐Coated Electrode

Wang

Luo

2003

Electroanalysis

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Electrocatalytic oxidation of thymine at a-cyclodextrin (a-CD) incorporated carbon nanotube-coated electrode (CNT/CE) was thoroughly studied in alkaline media. CNT showed an electrocatalytic effect on the oxidation of thymine, formation of a supramolecular inclusion complex between a-CD and thymine at CNT/CE further enhanced the sensitivity to thymine. The electrocatalytic behavior was further developed as a sensitive detection scheme for thymine by differential pulse voltammetry. A linear calibration over the concentration range from 2.5 Â 10 À5 to 1.8 Â 10À3 mol/L in pH 10.8 NaHCO 3 -Na 2 CO 3 buffer solution was obtained with a detection limit of 5 Â 10 À6 mol/L.

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Analytical Utilization of the Polarographic and Voltammetric Behavior of Purines and Pyrimidines.

Cited by 68 publications

References 20 publications

Voltammetric and impedance studies of inosine-5′-monophosphate and hypoxanthine

Voltammetric and impedance studies of inosine-5′-monophosphate and hypoxanthine

Electrochemical methods for determination of thymine in medical pipefish samples based on HPMαFP/Ppy/GCE-modified electrode

The Electrocatalytic Oxidation of Thymine at α‐Cyclodextrin Incorporated Carbon Nanotube‐Coated Electrode

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