Polarographic behaviour of loratadine and its direct determination in pharmaceutical formulation and human plasma by cathodic adsorptive stripping voltammetry

Stability studies on some benzocycloheptane antihistaminic agents

“…Methods have been described in the literature for the determination of loratadine whether alone or in combination with other drugs or in presence of its metabolites. The methods cited in the literature for the determination of loratadine as raw material or in dosage form (single or combined) included HPLC [3][4][5][6][7][8][9], capillary electrophoresis [10] spectrophotometric [5][6][7][11][12][13][14], polarographic [15,16] and densitometric method [7,17]. Methods used for the determination of loratadine in human plasma included HPLC [18][19][20] and a gas liquid chromatographic method [21].…”

Determination of Some Non-sedating Antihistamines via Their Native Fluorescence and Derivation of Some Quantitative Fluorescence Intensity - Structure Relationships

“…Among these methods are liquid chromatography (HPLC) [6][7][8][9][10][11], gas chromatography (GC) [12], electrochemical [13][14][15][16][17], and spectrophotometric methods (direct UV-, derivative-spectrophotometry, formation of ion-pair complexes, and charge transfer) [18][19][20][21][22].…”

Thermodynamic and Spectrophotometric Studies of Electron Donor-Acceptor Complexation Between Loratadine and Chloranilic Acid

“…Loratadine {(Ethyl-4-(8-chloro-5,6-dihydro-11H-benzo (5,6) cyclohepta (1,2-b) pyridine-1-piperidine carboxylate} is a second generation, non-sedating, long-acting antihistamine which is employed in the symptomatic relief of allergies such as hay fever, urticaria and seasonal allergic rhinitis and it elicits this effect by selective and peripheral antagonistic action on histamine -1 receptors [4]. Several methods have been reported for the determination of loratadine in pharmaceutical preparations including spectrophotometry [5], polarography [6], densitometry [7], capillary electrophoresis [8], gas chromatography [9], high performance liquid chromatography [10], liquid chromatographytandem mass spectrophotometry [11], spectrofluorimetric and potentiometric methods [12].…”

“…Several methods have been reported for the determination of loratadine in pharmaceutical preparations including spectrophotometry [5], polarography [6], densitometry [7], capillary electrophoresis [8], gas chromatography [9], high performance liquid chromatography [10], liquid chromatographytandem mass spectrophotometry [11], spectrofluorimetric and potentiometric methods [12]. Many of these methods require expensive equipment and/or are time-consuming [12]; hence the need to develop a method that is simple, sensitive and fast, yet reliable and reproductive.…”