Polarized Light (λ400–2000 nm) on Third-Degree Burns in Diabetic Rats: Immunohistochemical Study

Abstract

Our results suggest that the use of polarized light at 20 J/cm(2) effectively improves the healing of third-degree burns on diabetic animals at both early and late stages of repair.

Effects and parameters of the photobiomodulation in experimental models of third-degree burn: systematic reviewanalysis

“…Instrument heated until red and incandescent (11. 1%) [24,25] immersion in water at 95 °C (5.5%) [15], immersion in water at 100 °C (5.5%) [23], or cylindrical brass rod cooled to 77 K (5.5%) [21]. These find-ings suggested a good standardization between the experi-mental models of third-degree burns, allowing the reproduc-ibility of the experimental models (Table 1).…”

“…Of these, 1164 were excluded for not meeting the inclusion criteria of this systematic review: repeated study (n = 5), in vitro study (n = 120), clinical study (n = 62), systematic review (n = 76), ab-stract only (n = 47), it is not of third-degree burn (n = 854). Finally, 17 studies [4,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] in which diverse treatment pa-rameters of injuries were assessed were included for critical evaluation of the effectiveness of PBMT in third-degree burn. The 17 selected studies totaled a sample of 845 animals and showed some common characteristics, namely the use of adult male Wistar rat with a mean weight of 278.5 g as an experimental model and the dorsal region of the animals as the region where burns were performed in all (100%) studies.…”

“…Table 3 shows the parameters used in the selected studies. Whereas 72.2% of studies used a laser with a wavelength in the red spectrum, some authors chose a 632.8-nm laser [20,21]; others used a laser with a wavelength in the range of 660 nm [4, 10-12, 14, 15, 18, 19, 22], 685 nm [17], and 640 nm [13,23], and 5.5% used a laser with a wavelength of 890 nm [16], 11.1% used a laser with a wavelength of 780 nm [18,19,22], 11.1% used a laser with a wavelength of 400 nm [24,25], 5.5% used a laser with a wavelength of 520 and 550 nm [22], and used a laser with a wavelength of 2000 nm [24,25]. In relation to the power of the lasers, a very large variation was detected, ranging from 10 mW [20,21] to 100 mW [10,11]; the intermediate powers were as follows: 75 mW [16], 40 mW [22], 50 mW [10] (Table 4).…”

Evaluation of the Effects of Polarized Light (λ400–200 nm) on the Healing of Third-Degree Burns in Induced Diabetic and Nondiabetic Rats

“…It is important to note that the vascular response is very important in diabetic wound healing, as vascular diseases are a common complication in patients with uncontrolled diabetes and that that causes delay in the repair process. 28 Oliveira et al 29 showed, in the recent study, the effectiveness of PL with the low dose (10.2 J/cm 2 ) in improving the healing of third-degree burns in diabetic animals at both early (mainly on the angiogenesis) and late (mainly on re-epithelialization of repair) stages. 29 Meireles et al 17 have also confirmed the positive effect of the use of phototherapy on the healing of burns.…”

“…28 Oliveira et al 29 showed, in the recent study, the effectiveness of PL with the low dose (10.2 J/cm 2 ) in improving the healing of third-degree burns in diabetic animals at both early (mainly on the angiogenesis) and late (mainly on re-epithelialization of repair) stages. 29 Meireles et al 17 have also confirmed the positive effect of the use of phototherapy on the healing of burns. However, the positive effect was found with the use of a laser device, which is very costly when compared to PL devices.…”