Effects and parameters of the photobiomodulation in experimental models of third-degree burn: systematic reviewanalysis

Abstract

This systematic review was performed to identify the role of photobiomodulation therapy in experimental models of third-degree burns used to induce oxidative stress. EMBASE, PubMed, and CINAHL databases were searched for studies published between January 2003 and January 2018 on the topics of photobiomodulation therapy and third-degree burns. Any study that assessed the effects of photobiomodulation therapy in animal models of third-degree burns was included in the analysis. A total of 17 studies were selected from 1182 original articles targeted on photobiomodulation therapy and third-degree burns. Two independent raters with a structured tool for rating the research quality critically assessed the articles. Although the small number of studies limits the conclusions, the current literature research indicates that photobiomodulation therapy can be an effective short-term approach to accelerate the healing process of third-degree burns, to increase and modulate the inflammatory process, to accelerate the proliferation of fibroblasts, and to enhance the quality of the collagen network. However, differences still exist in the terminology used to describe the parameters and the dose of photobiomodulation therapy.

Effects of Photobiodulation Therapy in Patients With Third Degree Burns

“…Layer located just below the dermis, richly vascularized and innervated, due to its adipose constitution, it participates intensely in thermal insulation. Due to its deeper position in relation to the other layers, it provides support to the structures and because it is a looser tissue, it slides over the viscera and bones [1]. The connection between the dermis and hypodermis is carried out through elastin and collagen fibers, this layer works as a reservoir of energy, defense, physical shocks and fixation of the skin to adjacent structures, such as muscles and bones.…”

“…However, the healing process resulting from this pathology is slow, providing an environment conducive to infections and greatly increasing the hospitalization rate. For the management of wound treatment, prompt recovery and complete healing are still a major challenge [1].…”