Polarity of cortical electrical stimulation differentially affects neuronal activity of deep and superficial layers of rat motor cortex

Yazdan-Shahmorad, Azadeh; Kipke, Daryl R.; Lehmkuhle, Mark J.

doi:10.1016/j.brs.2010.11.004

Cited by 25 publications

(30 citation statements)

References 78 publications

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“…Upon completion of the experiment, electrolytic lesions were made followed by histological analysis to determine the electrode site locations within the different cortical layers (Yazdan-Shahmorad et al, 2011a,b, Parikh et al, 2009). In all cases, electrodes extracted from the brain were intact and were kept attached to the skull/headcap (Figure 2b).…”

Section: Methodsmentioning

confidence: 99%

“…100μm coronal slices were stained with a standard cresyl-violet (Nissl) staining method (Figure 2a). Exact stereotaxic positions of lesion marks and probe tracts were identified by co-registering histological images to the estimated probe locations from the images of the intact electrode arrays (Yazdan-Shahmorad et al, 2011a,b, Parikh et al, 2009). …”

Section: Methodsmentioning

confidence: 99%

“…Each unit was modeled with point process likelihood framework to relate the spiking propensity of each unit to factors associated with the stimulation parameters (frequency and amplitude) in the time intervals before the onset and after the offset of stimulation as described in detail in our previous work (Yazdan-Shahmorad et al, 2011a). The point process framework provides a flexible, computationally efficient approach for maximum likelihood estimation, goodness-of fit assessment, model selection, and neural coding (Truccolo et al, 2005).…”

Section: Methodsmentioning

confidence: 99%

“…To be able to understand and interpret the therapeutic effects of CES, it is critical to investigate the effects of CES parameters on neural activity in targeted regions of the brain. In our previous paper, we have shown a significant difference between the effects of pulse polarity (anodic versus cathodic) on unit firing rate recorded from different cortical layers (Yazdan-Shahmorad et al, 2011a). Our results showed an increase in unit activity following anodic stimulation and a decrease in unit activity following cathodic stimulation in lower layers (V-VI) units 500 ms following the offset of stimulation.…”

Section: Introductionmentioning

confidence: 98%

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High gamma power in ECoG reflects cortical electrical stimulation effects on unit activity in layers V/VI

2013

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Objective Cortical electrical stimulation (CES) has been used extensively in experimental neuroscience to modulate neuronal or behavioral activity, which has led this technique to be considered in neurorehabilitation. Because the cortex and the surrounding anatomy have irregular geometries as well as inhomogeneous and anisotropic electrical properties, the mechanisms by which CES has therapeutic effects is poorly understood. Therapeutic effects of CES can be improved by optimizing the stimulation parameters based on the effects of various stimulation parameters on target brain regions. Approach In this study we have compared the effects of CES pulse polarity, frequency, and amplitude on unit activity recorded from rat primary motor cortex with the effects on the corresponding local field potentials (LFP), and electrocorticograms (ECoG). CES was applied at the surface of the cortex and the unit activity and LFPs were recorded using a penetrating electrode array, which was implanted below the stimulation site. ECoGs were recorded from the vicinity of the stimulation site. Main results Time-frequency analysis of LFPs following CES showed correlation of gamma frequencies with unit activity response in all layers. More importantly, high gamma power of ECoG signals only correlated with the unit activity in lower layers (V-VI) following CES. Time-frequency correlations, which were found between LFPs, ECoGs and unit activity, were frequency- and amplitude-dependent. Significance The signature of the neural activity observed in LFP and ECoG signals provides a better understanding of the effects of stimulation on network activity, representative of large numbers of neurons responding to stimulation. These results demonstrate that the neurorehabilitation and neuroprosthetic applications of CES targeting layered cortex can be further improved by using field potential recordings as surrogates to unit activity aimed at optimizing stimulation efficacy. Likewise, the signatures of unit activity observed as changes in high-gamma power in ECoGs suggest that future cortical stimulation studies could rely on less invasive feedback schemes that incorporate surface stimulation with ECoG reporting of stimulation efficacy.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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High gamma power in ECoG reflects cortical electrical stimulation effects on unit activity in layers V/VI

2013

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“…This notion is further supported by a study that performed recordings in both superficial and deeper layers of the motor cortex in response to electrical stimulation of the cortical surface; neurons in deeper layers were found to be more sensitive to AF stimuli. 53 Thus clinically, at least for suprachoroidal prostheses, AF stimulation is recommended when using symmetric biphasic pulses.…”

Section: Stimulus Parameter Influence On Thresholdsmentioning

confidence: 99%

Factors Affecting Perceptual Thresholds in a Suprachoroidal Retinal Prosthesis

Shivdasani

Sinclair

Dimitrov

et al. 2014

Invest. Ophthalmol. Vis. Sci.

112

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With suprachoroidal stimulation, anodic-first pulses with a monopolar return are most efficacious. To enable high rates, an appropriate combination of pulse width and interphase gap must be chosen to ensure low thresholds and electrode voltages. Electrode-retina distance needs to be monitored carefully owing to its influence on thresholds. These results inform implantable stimulator specifications for a suprachoroidal retinal prosthesis. (ClinicalTrials.gov number, NCT01603576.).

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Coagulation Bath‐Assisted 3D Printing of PEDOT:PSS with High Resolution and Strong Substrate Adhesion for Bioelectronic Devices

Zheng

Wang

Zhang

et al. 2022

Adv Materials Technologies

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Poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is a promising material because of its favorable electrical and mechanical properties, stability in ambient environments, and biocompatibility. It finds broad application in energy storage, flexible electronics, and bioelectronics. Additive manufacturing opens a plethora of new avenues to form and shape PEDOT:PSS, allowing for the rapid construction of customized geometries. However, there are difficulties in printing PEDOT:PSS while maintaining its attractive properties. A 3D printing method for PEDOT:PSS using a room‐temperature coagulation bath‐based direct ink writing technique is reported. This technique enables fabrication of PEDOT:PSS into parts that are of high resolution and high conductivity, while maintaining stable electrochemical properties. The coagulation bath can be further modified to improve the mechanical properties of the resultant printed part via a one‐step reaction. Furthermore, it is demonstrated that a simple post‐processing step allows the printed electrodes to strongly adhere to several substrates under aqueous conditions, broadening their use in bioelectronics. Employing 3D printing of PEDOT:PSS, a cortex‐wide neural interface is fabricated, and intracranial electrical stimulation and simultaneous optical monitoring of mice brain activity with wide field calcium imaging are demonstrated. This reported 3D‐printing technique eliminates the need for cumbersome experimental setups while offering desired material properties.

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Polarity of cortical electrical stimulation differentially affects neuronal activity of deep and superficial layers of rat motor cortex

Abstract: Background-Cortical electrical stimulation (CES) techniques are practical tools in neurorehabilitation that are currently being used to test models of functional recovery after neurologic injury. However, the mechanisms by which CES has therapeutic effects, are not fully understood.

Cited by 25 publications

References 78 publications

High gamma power in ECoG reflects cortical electrical stimulation effects on unit activity in layers V/VI

High gamma power in ECoG reflects cortical electrical stimulation effects on unit activity in layers V/VI

Factors Affecting Perceptual Thresholds in a Suprachoroidal Retinal Prosthesis

Coagulation Bath‐Assisted 3D Printing of PEDOT:PSS with High Resolution and Strong Substrate Adhesion for Bioelectronic Devices

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