Polarity-Dependent Misperception of Subjective Visual Vertical during and after Transcranial Direct Current Stimulation (tDCS)

Santos-Pontelli, Taiza E. G.; Rimoli, Brunna P.; Favoretto, Diandra B; Mazin, Suleimy Cristina; Truong, Dennis Q.; Leite, João P.; Pontes-Neto, Octávio M.; Babyar, Suzanne; Reding, Michael; Bikson, Marom; Edwards, Dylan

doi:10.1371/journal.pone.0152331

Cited by 22 publications

(23 citation statements)

References 59 publications

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“…Restoration of "normal" bilateral PIVC balance may provide an opportunity for training more accurate postural control at least for a brief initial interval of tDCS. These findings also indicate that vestibular stimulation via GVS did not change mean COP-Xs as explained in previous studies with healthy subjects [6,7]. The lack of change via GVS may strengthen the argument that postural awareness and control are cortical functions that prioritize visual and proprioceptive sensory input over direct vestibular sensory input.…”

supporting

confidence: 83%

“…The lack of change via GVS may strengthen the argument that postural awareness and control are cortical functions that prioritize visual and proprioceptive sensory input over direct vestibular sensory input. The current density used in our study (2 mA/25 cm 2 or 0.08 mA/cm 2 ), as described previously [6], may have been too weak to produce an adequate, prolonged neuronal response.…”

mentioning

confidence: 87%

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Center of Pressure Speed Changes with tDCS Versus GVS in Patients with Lateropulsion after Stroke

et al. 2016

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supporting

confidence: 83%

mentioning

confidence: 87%

Center of Pressure Speed Changes with tDCS Versus GVS in Patients with Lateropulsion after Stroke

et al. 2016

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“…This functional distinction between TPJ and early visual cortex is in line with the role of TPJ in multisensory integration for perception of upright. A significant SVV shift has also been shown using transcranial direct current stimulation (tDCS) over TPJ ( 258 ). This shift was dependent on tDCS electrode placement, with SVV deviation toward the side of anode placement.…”

Section: Perception Of Upright and Cerebral Cortexmentioning

confidence: 99%

Perception of Upright: Multisensory Convergence and the Role of Temporo-Parietal Cortex

Kheradmand

Winnick

2017

Front. Neurol.

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We inherently maintain a stable perception of the world despite frequent changes in the head, eye, and body positions. Such "orientation constancy" is a prerequisite for coherent spatial perception and sensorimotor planning. As a multimodal sensory reference, perception of upright represents neural processes that subserve orientation constancy through integration of sensory information encoding the eye, head, and body positions. Although perception of upright is distinct from perception of body orientation, they share similar neural substrates within the cerebral cortical networks involved in perception of spatial orientation. These cortical networks, mainly within the temporo-parietal junction, are crucial for multisensory processing and integration that generate sensory reference frames for coherent perception of self-position and extrapersonal space transformations. In this review, we focus on these neural mechanisms and discuss (i) neurobehavioral aspects of orientation constancy, (ii) sensory models that address the neurophysiology underlying perception of upright, and (iii) the current evidence for the role of cerebral cortex in perception of upright and orientation constancy, including findings from the neurological disorders that affect cortical function.

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“…After stroke, vertical misperception and postural imbalance are frequent and negatively impact functional recovery ( 14 – 17 ). Targeting the TPJ, we recently showed that it is possible to manipulate perception of verticality ( 18 ) and postural control ( 19 ) in a polarity dependent manner during and after conventional tDCS over TPJ bilaterally (bipolar-balanced montage) ( 20 ). These studies provided support for restoration of visual vertical misperception and improved postural imbalance after stroke using tDCS over TPJ ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

Manipulation of Human Verticality Using High-Definition Transcranial Direct Current Stimulation

et al. 2018

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Background: Using conventional tDCS over the temporo-parietal junction (TPJ) we previously reported that it is possible to manipulate subjective visual vertical (SVV) and postural control. We also demonstrated that high-definition tDCS (HD-tDCS) can achieve substantially greater cortical stimulation focality than conventional tDCS. However, it is critical to establish dose-response effects using well-defined protocols with relevance to clinically meaningful applications.Objective: To conduct three pilot studies investigating polarity and intensity-dependent effects of HD-tDCS over the right TPJ on behavioral and physiological outcome measures in healthy subjects. We additionally aimed to establish the feasibility, safety, and tolerability of this stimulation protocol.Methods: We designed three separate randomized, double-blind, crossover phase I clinical trials in different cohorts of healthy adults using the same stimulation protocol. The primary outcome measure for trial 1 was SVV; trial 2, weight-bearing asymmetry (WBA); and trial 3, electroencephalography power spectral density (EEG-PSD). The HD-tDCS montage comprised a single central, and 3 surround electrodes (HD-tDCS3x1) over the right TPJ. For each study, we tested 3x2 min HD-tDCS3x1 at 1, 2 and 3 mA; with anode center, cathode center, or sham stimulation, in random order across days.Results: We found significant SVV deviation relative to baseline, specific to the cathode center condition, with consistent direction and increasing with stimulation intensity. We further showed significant WBA with direction governed by stimulation polarity (cathode center, left asymmetry; anode center, right asymmetry). EEG-PSD in the gamma band was significantly increased at 3 mA under the cathode.Conclusions: The present series of studies provide converging evidence for focal neuromodulation that can modify physiology and have behavioral consequences with clinical potential.

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Polarity-Dependent Misperception of Subjective Visual Vertical during and after Transcranial Direct Current Stimulation (tDCS)

Cited by 22 publications

References 59 publications

Center of Pressure Speed Changes with tDCS Versus GVS in Patients with Lateropulsion after Stroke

Center of Pressure Speed Changes with tDCS Versus GVS in Patients with Lateropulsion after Stroke

Perception of Upright: Multisensory Convergence and the Role of Temporo-Parietal Cortex

Manipulation of Human Verticality Using High-Definition Transcranial Direct Current Stimulation

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