Polar secondary metabolites of Ferula persica roots

Iranshahi, Mehrdad; Mojarab, Mehdi; Sadeghian, Hamid; Hanafi‐Bojd, Mohammad Yahya; Schneider, Bernd

doi:10.1016/j.phytochem.2007.08.001

Cited by 25 publications

(25 citation statements)

References 8 publications

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“…Ferula spp. and essential oils derived from these species are another important source of unique organosulfur compounds [14,16,[43][44][45]. In the present study, we defined the chemical profile of essential oils extracted from different parts of F. iliensis and evaluated the effect of these oils on phagocyte functions in vitro.…”

Section: Discussionmentioning

confidence: 99%

Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils

Özek

Schepetkin

Utegenova

et al. 2017

Journal of Leukocyte Biology

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Essential oil extracts from have been used traditionally in Kazakhstan for treatment of inflammation and other illnesses. Because little is known about the biologic activity of these essential oils that contributes to their therapeutic properties, we analyzed their chemical composition and evaluated their phagocyte immunomodulatory activity. The main components of the extracted essential oils were ()-propenyl -butyl disulfide (15.7-39.4%) and ()-propenyl -butyl disulfide (23.4-45.0%). essential oils stimulated [Ca] mobilization in human neutrophils and activated ROS production in human neutrophils and murine bone marrow phagocytes. Activation of human neutrophil [Ca] flux by essential oils was dose-dependently inhibited by capsazepine, a TRPV1 channel antagonist, indicating that TRPV1 channels mediate this response. Furthermore, essential oils stimulated Ca influx in TRPV1 channel-transfected HEK293 cells and desensitized the capsaicin-induced response in these cells. Additional molecular modeling with known TRPV1 channel agonists suggested that the active component is likely to be ()-propenyl -butyl disulfide. Our results provide a cellular and molecular basis to explain at least part of the beneficial therapeutic properties of FEOs.

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Section: Discussionmentioning

confidence: 99%

Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils

Özek

Schepetkin

Utegenova

et al. 2017

Journal of Leukocyte Biology

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“…-T he specieso ft he genus Ferula L. represent ar ich source of biologically active secondary metabolites and have been widely investigated duringthe last two decades.Plants of this genus have been used in the traditional medicine since ancient times,most frequently as antispasmodic, anthelmintic,antiflatulence,antidiarrheal, wound-healing, aphrodisiac,a nd antidiabeticr emedies [1][2][3][4].A dditionally, asafoetida, an oleo-gum resin obtained mainly from the underground parts of F. assafoetida L. (but also from F. aliacea Boiss., F. foetida Regel, F. narthex Boiss., F. rigidula Fisch.exDC.,and F. rubricaulis Boiss.) is commonly used in human diet, especially in India and Nepal [1].Onthe other hand, atoxic variety of F. communis L. is responsible for the lethal hemorrhagic syndromek nown as ferulosis,w hich mainly affects cattle and horses [5].…”

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confidence: 99%

Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffeliiGriseb. ex Heuff. and Its Metabolites

Pavlović

Petrović

Milenković

et al. 2015

Chemistry & Biodiversity

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The antimicrobial and cytotoxic activities of isolates (CHCl3 and MeOH extracts and selected metabolites) obtained from the underground parts of the Balkan endemic plant Ferula heuffelii Griseb. ex Heuff. were assessed. The CHCl3 and MeOH extracts exhibited moderate antimicrobial activity, being more pronounced against Gram-positive than Gram-negative bacteria, especially against Staphylococcus aureus (MIC=12.5 μg/ml for both extracts) and Micrococcus luteus (MIC=50 and 12.5 μg/ml, resp.). Among the tested metabolites, (6E)-1-(2,4-dihydroxyphenyl)-3,7,11-trimethyl-3-vinyldodeca-6,10-dien-1-one (2) and (2S*,3R*)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2,3-dihydro-7-hydroxy-2,3-dimethylfuro[3,2-c]coumarin (4) demonstrated the best antimicrobial activity. Compounds 2 and 4 both strongly inhibited the growth of M. luteus (MIC=11.2 and 5.2 μM, resp.) and Staphylococcus epidermidis (MIC=22.5 and 10.5 μM, resp.) and compound 2 additionally also the growth of Bacillus subtilis (MIC=11.2 μM). The cytotoxic activity of the isolates was tested against three human cancer cell lines, viz., cervical adenocarcinoma (HeLa), chronic myelogenous leukemia (K562), and breast cancer (MCF-7) cells. The CHCl3 extract exhibited strong cytotoxic activity against all cell lines (IC50 <11.0 μg/ml). All compounds strongly inhibited the growth of the K562 and HeLa cell lines. Compound 4 exhibited also a strong activity against the MCF-7 cell line, comparable to that of cisplatin (IC50 =22.32±1.32 vs. 18.67±0.75μM).

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“…As shown in the literature research above, this is a very well documented and widely used approach. To test the feasibility of this approach, it is subjected to a detailed review:  Analytical-scale separation and determination of molecular structure is a very well-researched area in the scientific field of substance discovery in plant extracts [40][41][42][43][44][45][46]. Nevertheless, these techniques are optimized with the focus being to identify one or at least a few substances.…”

Section: Solid-liquid-extractionmentioning

confidence: 99%

Characterization of Feed Properties for Conceptual Process Design Involving Complex Mixtures, Such as Natural Extracts

Josch¹,

Both²,

Strube³

2012

FNS

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The number of products used as agro-chemicals, food additives, flavors, aromas, pharmaceuticals and nutraceuticals which are made by fermentation or extraction from plants has increased significantly. Despite this growth, initial predictions for a potential product purification process for these complex mixtures remains entirely experimentally based. The present work represents an initial study to demonstrate the benefits of a systematic approach. For process development of chemically well-studied systems model based process design methods are already available. Therefore the proposed approach focuses on a method for the efficient characterization of the physical properties of the key components. Once this is adequately defined, unit operations and their potential to separate the feed components can be modeled. The current state of research is discussed. Based on this evaluation the most efficient method for conceptual process development has been identified and further developed. The resulting methodology consists of model-based cost accounting accompanied by experimental model-parameter determination. The latter is carried out at in miniaturized laboratory-scale measurement cells for each unit operation using the complete original feed. The model-based modelparameter determination from these experiments is accompanied by a comprehensive error analysis. The experimental plan currently includes the determination of thermodynamic equilibrium conditions in the mixture directly from the raw material mixture. Transport kinetics and fluid dynamic parameters are first estimated from known correlations or preexisting knowledge. Later on these parameters are determined exactly in mini-plant experiments. Furthermore, biological and botanical-based guidelines are developed to identify thermodynamically favored basic operations. Finally, the developed approaches are successfully validated using two plant extracts. Firstly, it could be proven that the botanical pre-selection can reduce the experimental plan significantly. Secondly, it was shown that the experimental equilibrium data of the kinetics and fluid dynamics can have a significant impact on the separation costs. Therefore, detailed rigorous modeling approaches have to be chosen instead of short-cut methods in order to make any valid process development conclusions or to further optimize the system.

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Polar secondary metabolites of Ferula persica roots

Cited by 25 publications

References 8 publications

Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils

Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils

Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffeliiGriseb. ex Heuff. and Its Metabolites

Characterization of Feed Properties for Conceptual Process Design Involving Complex Mixtures, Such as Natural Extracts

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