Poland since 1989

Substituted pyrrolyl-cyanopyridines on the platform of acylethynylpyrroles via their 1 : 2 annulation with acetonitrile under the action of lithium metal

“…For instance, pyrrole–pyridine ensembles are known as inhibitors of P38 kinase, 1 TNF (tumor necrosis factor) and IL1 (interleukin-1), 2 EGFR (epidermal growth factor receptor), 3 Ras-protein (proto-oncogenes that are frequently mutated in human cancers), 4 and prolyl 4-hydroxylase, 5,6 are active tuberculostatics 7 and antioxidants. 8 They have remarkable antiproliferative activities in vitro against melanoma, 9 have anti-HIV activity, 10 are capable of reducing misfolded rhodopsin for treating an inherited retinitis pigmentosa 11 and modulate capsid assembly and block hepatitis B virus replication. 12 The leucine aminopeptidase-based fluorescent detector of tumor cells also includes the pyrrolyl-pyridine structural unit.…”