Pola Pemberian Antibiotik Di Era Pandemi Covid-19 (Studi Kasus Di Rumah Sakit Nasional Diponegoro)

Putra, Dominikus Evano; Pramudo, Setyo Gundi; Arkhaesi, Nahwa; Retnoningrum, Dwi

doi:10.36408/mhjcm.v8i2.578

Cited by 6 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar findings were also reported in Dr. R. Koesma Tuban General Hospital, Indonesia, levofloxacin with 83.10 DDD/patient-days [ 16 ]. On the contrary, azithromycin had the highest DDD/100-patient days at Diponegoro National Hospital, Indonesia, while levofloxacin placed second in number [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Quantity of antibiotic use and its association with clinical outcomes in COVID-19 patients: A snapshot from a provincial referral hospital in Indonesia

Yossadania,

Hayati,

Harapan

et al. 2023

Narra J

View full text Add to dashboard Cite

Irrational antibiotic use in Indonesia is considered high, yet there are still lacks reliable information regarding the issue. The quantity of antibiotic use studies, in particular during coronavirus disease 2019 (COVID-19) pandemic, was not well reported. The aim of this study was to evaluate antibiotic use in COVID-19 patients at a province referral hospital in Aceh, Indonesia, Dr Zainoel Abidin Hospital, and to assess the association between antibiotic use and COVID-19 clinical outcomes. The defined daily dose (DDD) method was used and expressed in DDDs per 100 patient-days as in hospital setting. The data were obtained from inpatient confirmed COVID-19 patients between March 2020 and December 2021. A logistic regression was used to determine the association between patients’ characteristics and antibiotic usage with clinical outcomes. A total of 361 treated COVID-19 patients were included using a random sampling technique and analyzed. Out of 361 patients, 89.2% of them were treated with antibiotic(s). All the antibiotics were given empirically except for cefazoline (5.5%) that was used as prophylaxis to obstetric patients who underwent the c-section. Azithromycin was the most prescribed antibiotic and levofloxacin had the highest DDD. Our data suggested that there was no association between antibiotic use and clinical outcomes of COVID-19 patients (p=0.128). Having sepsis and another pulmonary disease however were associated with mortality of COVID-19 patients with adjusted odds ratio (aOR) 14.14; 95%CI 2.94–67.90, p=0.001 and aOR 8.64; 95%CI 3.30–22.63, p<0.001, respectively. In addition, patients older than 60-year-old had a higher chance to an unfavorable outcome compared to those younger than 30-year-old, aOR: 7.61; 95%CI: 1.07–53.94. In conclusion, the use of antibiotics is prevalent among COVID-19 and it is not directly associated with clinical outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

“…A similar azithromycin DDD calculation of 44.54 DDD/100-patient days was reported at Prof. Dr. R. D. Kandou General Hospital (tertiary hospital), Indonesia [ 19 ]. Diponegoro National Hospital revealed a higher number of 73.73 DDD/100-patient days among COVID-19 patients [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Quantity of antibiotic use and its association with clinical outcomes in COVID-19 patients: A snapshot from a provincial referral hospital in Indonesia

Yossadania,

Hayati,

Harapan

et al. 2023

Narra J

View full text Add to dashboard Cite

show abstract

“…This study is similar to a study that analyzed the antibiotics utilization with the ATC DDD/ 100 bed days method in the early COVID-19 pandemic where there was the use of beta-lactam antibiotics (ceftriaxone, carbapenems, cephalosporins/betalactamase inhibitors) and azithromycin in a hospital (Gay et al, 2012). Another study stated that the most antibiotics given to COVID-19 patients were azithromycin, levofloxacin, and ceftriaxone, with the value of DDD/bed days respectively 48.12; 44.01; and 21.13 DDD/ 100 bed days (Putra et al, 2021). Sputum cultures of COVID-19 patients were carried out on research samples and observed bacteria growing to determine the possibility of bacterial co-infection in patients.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Antibiotic Use in COVID-19 Patients at a Hospital in Sidoarjo

Kristanti

Yulia²,

Herawati³

2022

JFIKI

View full text Add to dashboard Cite

Background: Antibiotics are given to COVID-19 patients to treat bacterial co-infections, but excessive and inappropriate antibiotic use can increase antibiotic resistance. Objective: The study aims to analyze the antibiotic use and bacterial susceptibility in COVID-19 patients at a hospital in Sidoarjo - East Java. Method: The research design used was a prospective cross-sectional study using data collection of sputum culture, bacterial susceptibility, medical records, and Pharmacy antibiotics usage from August to October 2021. The Research sample is moderate-to-severe COVID-19 patients. Result: The results showed that in August-October 2021, 32 patients met the study sample category, where the most were men (56.25%), age range 46-55 years (31.25%), and outcome recovered as much as 81.25%. The culture results showed that only 1 (one) person out of 32 samples had bacterial growth. The only bacteria that grew in the sputum culture was Enterobacter aerogenes, susceptible to meropenem but resistant to levofloxacin. The highest quantity of antibiotics in this study was levofloxacin 71,16; meropenem 32.25; moxifloxacin 21.84 DDD/ 100 bed days. Conclusions: Most of the cases of COVID-19 occurred in men; the age range was 46-55 years, and the outcome recovered was more than those who died. Bacterial co-infection occurred in 3.12% of patients who received meropenem and levofloxacin during their hospitalization. The largest quantity of antibiotics used was levofloxacin, meropenem, and moxifloxacin. The combination of meropenem and levofloxacin should be re-evaluated because levofloxacin is resistant but still susceptible to meropenem.

show abstract

“…Penelitian yang dilakukan di instalasi rawat inap Rumah Sakit Nasional Diponegoro (RSND) terhadap 141 peresepan antibiotik memperlihatkan bahwa antibiotik yang paling banyak digunakan pada pasien Covid-19 adalah azitromisin, levofloksasin, dan ceftriakson dengan nilai DDD/100 pasienhari masing-masing 48,12; 44,01; dan 21,13. Berdasarkan kriteria gyssens, terdapat 51.1% antibiotik digunakan dengan tidak rasional dan 13.5% tidak ada indikasi penggunaan antibiotik (Putra et al, 2021).…”

Section: Pendahuluanunclassified

“…Meskipun insiden rendah (8%) dari koinfeksi yang dilaporkan diantara pasien dengan Covid-19, 72% pasien menerima terapi antibiotik (Rawson et al, 2020) Antibiotik yang paling banyak diresepkan adalah levofloxacin i.v dengan persentase 35,59% dan antibiotik kedua terbanyak adalah ceftriakson i.v sebesar 30,35%. Levofloksasin dan ceftriakson merupakan antibiotik yang paling sering diresepkan pada pasien Covid-19 (Putra et al, 2021;Khan et al, 2022;Cong et al, 2022). Kedua antibiotik tersebut berasal dari kategori Watch (kategori WHO AWaRe).…”

Section: Hasilunclassified

EVALUASI PENGGUNAAN ANTIBIOTIK PASIEN COVID-19 MENGGUNAKAN METODA GYSSENS DAN ATC/DDD DI RSAU Dr. M. SALAMUN KOTA BANDUNG

Dewi¹,

Sitorus

2023

View full text Add to dashboard Cite

Potensi penggunaan antibiotik yang berlebih dan tidak tepat pada era pandemi Covid-19 menjadi ancaman global terhadap meningkatnya kejadian resisten antibiotik dan berdampak pada peningkatan morbiditas, mortalitas, dan biaya kesehatan. Terlebih lagi, patogen yang menyebabkan infeksi resisten berkembang di fasilitas kesehatan, yang berisiko bagi pasien dan berpengaruh pada manajemen Covid-19. Penelitian ini bertujuan untuk mengevaluasi penggunaan antibiotik secara kuantitas dan kualitas di RSAU Dr. M. Salamun Kota Bandung. Penilaian kuantitas dan kualitas penggunaan antibiotik dilakukan berdasarkan DDD (Defined Daily Dose)/100 pasien-hari dan kriteria van der Meer–Gyssens. Penelitian menggunakan metoda consecutive sampling dan dilakukan secara retrospektif terhadap 271 rekam medis. Terdapat 458 peresepan antibiotik, dengan antibiotik yang paling banyak diresepkan pada pasien Covid-19 rawat inap adalah levofloksasin intravena dengan persentase 35,59% dan antibiotik kedua terbanyak adalah ceftriakson intravena sebesar 30,35%. Berdasarkan DDD/100 pasien-hari, kuantitas antibiotik yang paling banyak digunakan adalah levofloksasin intravena dengan 53,416 DDD/100 patient-days. Tipe terapi pada keseluruhan peresepan antibiotik bersifat empiris (Antimicrobial Drug Empiric Therapy). Berdasarkan kriteria Gyssens, 63,97% penggunaan antibiotik secara rasional, 31,01% penggunaan antibiotik tidak rasional, dan 5,02% tanpa indikasi. Dapat disimpulkan bahwa secara kuantitas, antibiotik yang paling banyak digunakan adalah levofloksasin intravena dan ceftriakson intravena. Secara kualitas, 63,97% antibiotik digunakan secara rasional berdasarkan kriteria Gyssens. Kata kunci : Covid-19; Antibiotik; DDD/100 pasien-hari; kriteria Gyssens

show abstract

Pola Pemberian Antibiotik Di Era Pandemi Covid-19 (Studi Kasus Di Rumah Sakit Nasional Diponegoro)

Cited by 6 publications

References 0 publications

Quantity of antibiotic use and its association with clinical outcomes in COVID-19 patients: A snapshot from a provincial referral hospital in Indonesia

Quantity of antibiotic use and its association with clinical outcomes in COVID-19 patients: A snapshot from a provincial referral hospital in Indonesia

Analysis of Antibiotic Use in COVID-19 Patients at a Hospital in Sidoarjo

EVALUASI PENGGUNAAN ANTIBIOTIK PASIEN COVID-19 MENGGUNAKAN METODA GYSSENS DAN ATC/DDD DI RSAU Dr. M. SALAMUN KOTA BANDUNG

Contact Info

Product

Resources

About