Pola Kuman dan Sensitifitas Antibiotik di Ruang Perinatologi

Kardana, I Made

doi:10.14238/sp12.6.2011.381-5

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…There are several factors that can influence the shift in bacterial patterns, that is: differences in immune responses, population genetic factors, differences in the way of microbiological analysis, differences in levels of education, and health services as well as changes in the pattern of antibiotic use (inappropriate administration of antimicrobials in empirical therapy and inappropriate infection control strategies) [13]. Hence, the differences in the types of bacteria could possibly be caused by several factors including research methods, research tools and media used, room and air conditions, and the quantity of bacterial colonies that grew differently.…”

Section: Discussionmentioning

confidence: 99%

Bacterial Profile of Chronic Kidney Failure Patients and their Sensitivity to Meropenem at General Hospital

Isnawati¹,

Prayitno

2023

Open Access Maced J Med Sci

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BACKGROUND: Patients with chronic kidney disease (CKD) tend to have low immunity so they are easily infected. Treatment using meropenem is relatively safe but must be based on antibiotic sensitivity testing to prevent resistance. AIM: The aim of the study was to determine the bacterial profile and its sensitivity to the antibiotic meropenem in patients with end-stage chronic renal failure. METHODS: This was a quantitative, descriptive, and cross-sectional research. Data derived from medical records of selected hospitals. The sample was based on inclusion and exclusion criteria with ICD10 N18.0 and N18.5 codes in January–December 2016. Data are processed with descriptive statistics. RESULTS: There were 39 CKD patient at Hospital X and 29 respondents at Hospital Y that received meropenem. There were only 14 CKD patients at hospital X and 22 CKD patients at hospital Y with culture tests and results. There were nine samples in Hospital X and 29 samples in Hospital Y that showed bacterial growth. There were 31 (81.58%) g negative bacteria, 6 (15.79%) g positive bacteria, and 1 (2.63%) aerob bacteria. Citrobacter from samples of pus and Acinetobacter baumannii (×1) from urine samples were resistant to meropenem. CONCLUSION: The majority of bacterial culture results are Gram-negative. Eschericia coli bacteria are the most commonly Gram-negative bacteria. Citrobacter bacteria and A. baumannii bacteria are resistant to meropenem.

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Section: Discussionmentioning

confidence: 99%

Bacterial Profile of Chronic Kidney Failure Patients and their Sensitivity to Meropenem at General Hospital

Isnawati¹,

Prayitno

2023

Open Access Maced J Med Sci

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“…Kepmenkes, 2017). Namun, di negara maju didapatkan hasil yang berlawanan, penyebab sepsis terutama sepsis neonatorum awitan dini paling sering disebabkan oleh bakteri gram positif (Kardana, 2011). Perbedaan ini dapat terjadi karena pola bakteri penyebab sepsis berbeda-beda antar negara dan selalu berubah dari waktu ke waktu.…”

Section: Karakteristik Hasil Kultur Bakteriunclassified

Evaluasi Ketepatan Antibiotik pada Pasien Sepsis

2021

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The administration of early intravenous antibiotics was one of the fundamental procedures in sepsis. Inappropriate of antibiotics in septic patients has an impact on mortality and prolongs treatment. The purpose of this study was to evaluate the appropriateness of antibiotics therapy in hospitalized sepsis patients in Central Java based on the parameters right indication, right patient, right drug, and the right dose. This study was observational. Data collected retrospectively and analyzed descriptively. Sampling was done by purposive sampling. The inclusion criteria were inpatients diagnosed with sepsis who received antibiotics therapy with complete medical record data. The exclusion criteria were patients who died of sepsis. Antibiotics analyzed using the DIH 25th edition 2016, IONI 2014, Tata Laksana Sepsis Pada Anak IDAI 2016, Neofax 2014, Kepmenkes PNPK Tata Laksana Sepsis 2017, PPK RS, and SHC Antimicrobial Dosing 2017. Based on data from 108 patients who fulfilled the inclusion criteria obtained results right indication 100%, right patient 97.22%, right drug 90.74%, and the right dose 48.15%. The most used antibiotic was a combination of ampicillin and gentamicin (41.67%), while the single antibiotic was ceftriaxone (12.96%).

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“…1,2 Adanya resistensi antibiotik di lingkungan rumah sakit memiliki beberapa dampak negatif, di antaranya adalah dapat memperpanjang waktu rawat di rumah sakit hingga 35%, meningkatkan biaya rawat, dan meningkatkan mortalitas. [1][2][3][4][5] Data epidemiologi di Indonesia memperlihatkan bahwa angka resistensi antibiotik lini pertama (ampisilin dan gentamisin) pada kasus sepsis neonatus awitan dini (SNAD) di beberapa unit perinatologi rumah sakit di Indonesia cukup tinggi, misalnya di Rumah Sakit Umum Pusat (RSUP) Sanglah Denpasar (ampisilin 63%, gentamisin 60%), 6 RSUP H. Adam Malik Medan (ampisilin 72%, gentamisin 53%), 7 dan Rumah Sakit Cipto Mangunkusumo (RSCM) Jakarta (ampisilin 80%, gentamisin 33%). 8 Secara khusus pada populasi neonatus, penggunaan antibiotik yang tidak rasional dapat meningkatkan kejadian infeksi jamur (candidiasis), necrotizing enterocolitis (NEC), dan sepsis neonatus awitan lambat (SNAL).…”

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Laporan kasus berbasis bukti: Antibiotic Stewardship Sebagai Upaya Mengurangi Pemakaian Antibiotik pada Sepsis Neonatus Awitan Dini

Rohsiswatmo

Samsudin

2021

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Latar belakang. Pemberian antibiotik secara tidak rasional meningkatkan resistensi. Antibiotic stewardship program (ASP) adalah strategi untuk mengurangi pemakaian antibiotik pada kasus sepsis neonatus awitan dini (SNAD) di unit perinatologi.Tujuan. Mengurangi pemakaian antibiotik di unit perinatologi dengan ASP. Metode. Penelusuran literatur elektronik PubMed, Cochrane dan Google Scholar dengan kata kunci ”antibiotic stewardship” atau “antibiotic duration” dan “perinatology” dan “neonatal sepsis” dalam 6 tahun terakhir (2013-2019). Hasil. Uji klinis acak terkontrol oleh Rohatgi dkk mencakup 132 bayi dengan SNAD, diberikan antibiotik empiris selama 7 dan 10 hari. Tidak ditemukan perbedaan bermakna pada durasi pemakaian oksigen, inotropik, transfusi darah dan waktu minum enteral penuh (p>0,05). Cantey dkk melakukan studi time series prospektif dengan menghentikan antibiotik setelah 48 jam terhadap 2502 bayi berat lahir <2100 gram dengan SNAD, hari pemakaian antibiotik menurun 27% (p<0,0001). Studi time series restrospektif pada 537 bayi dengan diagnosis SNAD oleh Grant dkk melakukan pemeriksaan c-reactive protein (CRP) pada usia 36 jam dan pemberhentian antibiotik empiris setelah 48 jam. Angka kepatuhan tenaga medis pada akhir penelitian mencapai 97,5%, dan pemakaian antibiotik lebih dari 48 jam menurun dari 50,4% menjadi 0,8% (p<0,0001). Kesimpulan. Antibiotic Stewardship Program dapat mengurangi pemakaian antibiotik untuk kasus SNAD pada unit perinatologi.

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Pola Kuman dan Sensitifitas Antibiotik di Ruang Perinatologi

Abstract: orld Health Organization (WHO) memperkirakan setiap tahun terdapat 130 juta bayi baru lahir di seluruh dunia, dan diperkirakan 4 juta bayi meninggal pada usia empat minggu pertama kehidupan. Penyebab kematian neonatal adalah kelahiran kurang bulan (28%), infeksi (26%), asfiksia

Cited by 6 publications

References 7 publications

Bacterial Profile of Chronic Kidney Failure Patients and their Sensitivity to Meropenem at General Hospital

Bacterial Profile of Chronic Kidney Failure Patients and their Sensitivity to Meropenem at General Hospital

Evaluasi Ketepatan Antibiotik pada Pasien Sepsis

Laporan kasus berbasis bukti: Antibiotic Stewardship Sebagai Upaya Mengurangi Pemakaian Antibiotik pada Sepsis Neonatus Awitan Dini

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