Poisonings with diphenhydramine—A survey of 68 clinical and 55 death cases

Pragst, F.; Herre, Sieglinde; Bakdash, Abdulsallam

doi:10.1016/j.forsciint.2006.01.019

Cited by 82 publications

(49 citation statements)

References 27 publications

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“…It was present in lethal quantities in 14% of all suicides. There have been numerous case reports of diphenhydramine toxicity resulting in death and at least 1 larger study, 16 over a 13-year period in Berlin, where 55 fatal diphenhydramine poisonings were reported with an unspecified majority of those being suicides. Historically, acetaminophen has tended to be the most common OTC medication used worldwide in intentional overdose 17 and, in England and Wales, it accounted for at least 200 deaths in 1997 alone.…”

Section: Lethal Substances Usedmentioning

confidence: 99%

Substances Used in Completed Suicide by Overdose in Toronto: An Observational Study of Coroner's Data

et al. 2012

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Objective: To identify the substances used by people who die from suicide by overdose in Toronto and to determine the correlates of specific categories of substances used. Method:Coroner's records for all cases of suicide by overdose in Toronto, Ontario, during a 10-year period (1998 to 2007) were examined. Data collected included demographic data, all substances detected, and those determined by the coroner to have caused death. Logistic regression analyses were used to examine demographic and clinical factors associated with suicide by different drug types.Results: There were 397 documented suicides by overdose (mean age 49.1 years, 50% female). Most substances detected were psychotropic prescription medications (n = 245), followed by other prescription medications (n = 143) and over-the-counter (OTC) medications (n = 83). More than one-half of all suicides by overdose were determined to have only one specific substance as the cause of death (n = 206). In suicides where only one class of substance was present in lethal amounts, OTC medication (n = 48), opioid analgesics (n = 44), and tricyclic antidepressants (n = 44) were most common. Conclusions:Suicides by overdose involved the use of different classes of substances, including psychotropic prescription medication, other prescription medications, as well as OTC medications. Physicians and pharmacists should be aware of commonly used prescription and OTC medications in overdose and exercise increased vigilance in prescribing or dispensing them to at-risk patients. W W WObjectif : Identifier les substances utilisées par les personnes qui meurent d'un suicide par surdose à Toronto et déterminer les corrélats des catégories spécifiques des substances utilisées.Méthode : Les dossiers du coroner pour tous les cas de suicide par surdose à Toronto, Ontario, durant une période de 10 ans (de 1998 à 2007) ont été examinés. Les données recueillies comprenaient les données démographiques, toutes les substances détectées, et celles que le coroner a déterminé avoir causé la mort. Les analyses de régression logistique ont servi à examiner les facteurs démographiques et cliniques associés au suicide par différents types de drogues.Résultats : Il y a eu 397 suicides par surdose documentés (âge moyen 49,1 ans, 50 % féminins). La plupart des substances détectées étaient des médicaments psychotropes sur ordonnance (n = 245), suivies d'autres médicaments sur ordonnance (n = 143) et de médicaments en vente libre (EVL; n = 83). Il a été déterminé que plus de la moitié de tous les suicides par surdose n'avaient qu'une seule substance spécifique comme cause du décès (n = 206). Dans les suicides où une seule classe de substance était présente en quantité mortelle, un médicament EVL (n = 48), un analgésique opioïde (n = 44), et un antidépresseur tricyclique (n = 44) étaient les plus communs. Conclusions :Les suicides par surdose comportaient l'utilisation de différentes classes de substances, dont des médicaments psychotropes sur ordonnance, d'autres médicaments sur ordonnance, ainsi q...

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Section: Lethal Substances Usedmentioning

confidence: 99%

Substances Used in Completed Suicide by Overdose in Toronto: An Observational Study of Coroner's Data

et al. 2012

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“…Tolerance does exist with this OTC medication, and withdrawal results in sedation and memory impairment. 42,43 Hydroxycut Because herbal products are not subject to the same rigorous Food and Drug Administration regulations that are required for prescription and OTC products, consumers unknowingly risk adverse effects when taking these products. A 22-year-old man was hospitalized after unexplained seizure-like activity and unresponsiveness.…”

Section: Diphenhydraminementioning

confidence: 99%

Abuse of Prescription and Over-the-Counter Medications

Lessenger

Feinberg

2008

The Journal of the American Board of Family Medicine

143

124

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The nonmedical use of prescription or over-the-counter (OTC) medications implies that the user is using them for reasons other than those indicated in the prescribing literature or on the box label. The abuse of these medications is a national issue.Intentional The nonmedical use of a prescription or over-thecounter (OTC) medication implies that the user is using it for reasons other than those indicated in the prescribing literature or on the box label.1 The abuse of these medications is a national issue. Prescription medications are those pharmaceuticals dispensed by a pharmacist on the presentation of a prescription written by a physician, dentist, or other health care provider who is legally authorized to write prescriptions. OTC medications are pharmaceuticals that do not require a prescription and are sold on the shelves of markets, stores, and pharmacies.

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“…Tramadol, diphenhydramine, paracetamol, nicotine and cotinine (purchased from LGC Promochem (Wesel, Germany)) were quantitatively analyzed in femoral venous blood by protein precipitation with acetonitrile as well as by high-performance liquid chromatography (RP-HPLC) using a Purospher RP-18 microm column with a flow rate of 1.2 mL in the system acetonitrile/phosphoric acid (0.072%), obtained from Merck (Darmstadt, Germany) [15,16].…”

Section: Toxicological Examinationmentioning

confidence: 99%