Poisoning from henna dye and para-phenylenediamine mixtures in children in Khartoum

Hashim, Mohammed; Hamza, Yaser; Yahia, B. Ben; Khogali, F M; Sulieman, G I

doi:10.1080/02724936.1992.11747539

Cited by 71 publications

(56 citation statements)

References 8 publications

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“…Many cases of toxicity and mortality either due to its accidental or deliberate ingestion were reported in Egypt, Sudan, Israel, Morocco, Saudi Arabia, India and Tunisia (Sir Hashim et al, 1992). PPD is well known as a skin irritant and sensitizer, and allergic contact dermatitis may occur after exposure to PPD in hair dye (Picardo et al, 1996;McFadden et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen

et al. 2016

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-Paraphenylene daimine (PPD) is an aromatic amine that is widely used in several industrial products; however, its toxicity has been reported in several cases of cardiac arrests. As platelets play a key role in cardiovascular diseases, we aimed to determine the impact of PPD in vitro and in vivo on platelet function. Our findings demonstrated that platelet activation and aggregation were strongly enhanced by PPD. Treatment with PPD primed human platelets that became more reactive in response to low doses of collagen. Furthermore, PPD exacerbated thrombus formation in rats in comparison with those untreated. Our results suggest that PPD is an important platelet primer predisposing platelets to promote thrombus formation in response to vascular injury. This should prompt the authorities to consider controlling the marketing of this product.

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Section: Introductionmentioning

confidence: 99%

Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen

et al. 2016

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“…Morbidity and mortality are directly proportional to renal failure. It was as high as 41%in study by Hashim et al [6] The mortality rate was 9 per 100 and 8 out of 9 deaths occurred in patients with renal failure.…”

Section: Discussionmentioning

confidence: 88%

“…Except for a study in sudan by Sir Hashim M et al, ere children were mostly intoxicated hair dye poison is usually common in young adults. [6] The mean time to reach the hospital in our study was 3 hours 20 minutes. It was as high as 32hours in a study conducted by Anugrah cristpal et al [7] The predicted quantity of hair dye consumed for development of symptoms and to undertake tracheostomy was 60 ml.…”

Section: Discussionmentioning

confidence: 99%

Tracheostomy in Hair Dye Poisoning - Indications and Clinical Outcome

D¹,

M²,

Aishwarya³

et al. 2017

AIMDR

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Background: Hair dye ingestion is an attractive means of deliberate self harm because of its low cost and unrestricted availability and is common in rural south India. Patients present with compromised airway due to upper respiratory tract edema, facial and neck edema. Aim: To determine the criteria for managing airway by tracheostomy in patients with hair dye poisoning. Methods: This study was conducted in Tirunelveli medical college and patients with alleged history of consuming hair dye were included in study. Patients who mixed other poisons with hair dye were excluded from study. ENT examination to identify edema of oral cavity, pharynx, larynx and neck and facial edema was routinely performed. If the patient had edema with fall in SpO2 and breathing difficulty, tracheostomy was done. Results: The mean duration between consumption of hair dye to development of symptoms was 3.0 ±1.5 hours and the same to tracheostomy was 5± 2.2 hrs. Tracheostomy increased the need for hospitalization 16.4 ± 9.4 days. Patients had swallowing problems due to pharyngeal edema and tracheostomy further delayed the initiation of oral feeds 8.3±5.3 days. Conclusion: The amount of hair dye consumed and time of presentation to the hospital are an important risk factor for developing oropharyngeal edema, which in turn determines the risk of mortality.

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“…6 High mortality within 24 hrs was noted in Hashim et al study 41% (13 out of 31). 13 In our study, the proportion of mortality in 165 patients is 21 (12.72 %), in tracheosomty patients 7 (6.08%) and in non tracheostomy patients 14 (28%). In study by Nirmala the propotion of mortality in 108 patients is 24 (22.2 %), in tracheosomty patients 7 (21.2%) and in non tracheostomy patients 17 (22.7%).…”

Section: Discussionmentioning

confidence: 95%

“…Chronic illness 10 6.06 Other social problems 13 Out of 115, tracheostomy done 108 patients were alive and 7 expired while patients in whom tracheostomy was not done 36 were alive and 14 died (Table 5).…”

Section: Resultsmentioning

confidence: 99%

Pathar dye (paraphenyldiamine) poisoning: our experience of this lethal emerging health problem in a tertiary care centre

Nautiyal

Tiwari

Ashutosh

2017

Int J Otorhinolaryngol Head Neck Surg

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<div class="page" title="Page 1"><div class="section"><div class="layoutArea"><div class="column"><p class="abstract"><strong>Background:</strong> The aim of this case series study is to share our experiences regarding paraphenylenediamine (PPD) poisoning, its otolaryngological clinical presentation ,outcomes and need of tracheostomy in patients of hair dye poisoning at GSVM Medical College, Kanpur, U.P.</p><p class="abstract"><strong>Methods:</strong> This prospective study was carried out on 165 patients who presented in GSVM medical college Kanpur in period of December 2012 till December 2014. Data including demographic features (age, sex, marital status, socio-economic status), clinical features, laboratory findings, mode of intoxication (accidental or suicide) were collected and recorded. </p><p class="abstract"><strong>Results:</strong> A majority of the patients were young females (21-30 years) and belonged to a low socioeconomic class. The main cause was intentional suicidal ingestion. Cervicofacial edema, stridor, hoarseness of voice and pain in throat were initial symptoms. Tracheostomy was needed in 115 (69.69%) patients. Mortality of 21 (12.72%) patients was observeds.</p><p><strong>Conclusions:</strong> It is a major emerging health problem with high mortality. It is a medical emergency and early intervention is needed to save patient's life. It is imperative to raise public awareness of the potential toxicity of the dye as well as to educate physicians about the need for aggressive and early treatment. </p></div></div></div></div>

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Poisoning from henna dye and para-phenylenediamine mixtures in children in Khartoum

Cited by 71 publications

References 8 publications

Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen

Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen

Tracheostomy in Hair Dye Poisoning - Indications and Clinical Outcome

Pathar dye (paraphenyldiamine) poisoning: our experience of this lethal emerging health problem in a tertiary care centre

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