Pointwise Univariate Linear Regression of Perimetric Sensitivity Against Follow-up Time in Glaucoma

Wild, J. Martin; Hutchings, Natalie; Hussey, Matthew; Flanagan, John G.; Trope, Graham E.

doi:10.1016/s0161-6420(97)30229-2

Cited by 48 publications

(26 citation statements)

References 24 publications

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“…However, from the data shown here, it is clear that criteria such as 1 point changing with a slope of 1 dB/year and Po0.001 8-10 would probably detect change over shorter periods of follow-up (Figure 1). Previous work has also noted the detection of improvement using PLR; [8][9][10][11] however, some early work assumed that those patients without points with significant negative slope should be labelled as not changing. 7,12 What is clear from the data in this study is the appearance of patients showing both progression and improvement when lax criteria are used.…”

Section: Discussionmentioning

confidence: 99%

“…6 Early PLR criteria were arbitrary, and the investigators using them had no 'gold standard' to use, a situation that persists. The criteria chosen required one [6][7][8][9][10][11] or two points 12,13 to be changing. The minimum critical slope was specified as being o0 dB/year, 8,9,13 oÀ1 dB/ year, 6,10,12 oÀ2.4 dB/year 7 or onormal age decline.…”

Section: Introductionmentioning

confidence: 99%

“…The minimum critical slope was specified as being o0 dB/year, 8,9,13 oÀ1 dB/ year, 6,10,12 oÀ2.4 dB/year 7 or onormal age decline. 11 The level of significance or P-value used has not always been reported; 11,12 but where it has, the values chosen have been Po0.0009, 13 Po0.001, [8][9][10] and Po0.05. 6,7 Criteria from some of the studies mentioned above were used to analyse the visual fields from the UK Medical Research Council (MRC)/Moorfields 5-FU Filtration (More flow) Surgery Study.…”

Section: Introductionmentioning

confidence: 99%

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Pointwise linear progression criteria and the detection of visual field change in a glaucoma trial

Wilkins

Fitzke²,

Khaw

2005

Eye

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Background Current pointwise linear regression (PLR) change criteria for visual field analysis are largely empirical. Methods Two independent sets of Humphrey Field Analyzer fields were analysed using PLR. Set i, 56 patients, and set ii, 97 patients, were followed over 16 months. Criteria were tested against set i, and then validated using set ii. Each criterion specified a fixed critical slope of 1 dB/year and with a range of significance from Po0.001 to 0.05. The criteria were varied by altering location number, cluster arrangement, and by requiring points to show change over both 12 and 16 months. True glaucomatous change was differentiated from noise by looking for exclusive progression (EP), the detection of progression without detection of improvement. Results Set i required 1 point to have a slope of 1 dB/year and Po0.05 labelled 64% progressing and 58% improving, whereas several stricter criteria were capable of detecting EP. Two points in a perimetric nerve fibre bundle (PNFB) cluster gave optimal EP detection, labelling 8.9% progressing in set i and 7.2% progressing in set ii with a cutoff P-value of 0.026 inset i and 0.013 inset ii. Conclusion Lax PLR criteria detect large amounts of change. Validating criteria using two data sets allow selection of better criteria, capable of detecting EP. The criterion involving 2 points changing in a PNFB cluster offers the best option for exclusively detecting progression.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pointwise linear progression criteria and the detection of visual field change in a glaucoma trial

Wilkins

Fitzke²,

Khaw

2005

Eye

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“…By far the most common approach is to use pointwise univariate linear regression (PWLR) to detect trends in individual locations [2,8,20,22,23,27]. Typically this is applied to each individual location, and if the slope of the fitted line is significantly less than zero the patient is classified as progressing.…”

Section: Determining Progressionmentioning

confidence: 99%

“…Typically this is applied to each individual location, and if the slope of the fitted line is significantly less than zero the patient is classified as progressing. Several variations on this theme have been investigated, the most notable being to correct for natural age-related decline in thresholds [27]. Performing PWLR on each of the 76 locations introduces a multiple-comparison problem.…”

Section: Determining Progressionmentioning

confidence: 99%

Determining Progression in Glaucoma Using Visual Fields

Turpin

Frank

Hall

et al. 2001

Advances in Knowledge Discovery and Data Mining

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Abstract. The standardized visual field assessment, which measures visual function in 76 locations of the central visual area, is an important diagnostic tool in the treatment of the eye disease glaucoma. It helps determine whether the disease is stable or progressing towards blindness, with important implications for treatment. Automatic techniques to classify patients based on this assessment have had limited success, primarily due to the high variability of individual visual field measurements. The purpose of this paper is to describe the problem of visual field classification to the data mining community, and assess the success of data mining techniques on it. Preliminary results show that machine learning methods rival existing techniques for predicting whether glaucoma is progressing-though we have not yet been able to demonstrate improvements that are statistically significant. It is likely that further improvement is possible, and we encourage others to work on this important practical data mining problem.

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Initial Treatment for Open-Angle Glaucoma—Medical, Laser, or Surgical?

Hitchings

1998

Arch Ophthalmol

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Pointwise Univariate Linear Regression of Perimetric Sensitivity Against Follow-up Time in Glaucoma

Cited by 48 publications

References 24 publications

Pointwise linear progression criteria and the detection of visual field change in a glaucoma trial

Pointwise linear progression criteria and the detection of visual field change in a glaucoma trial

Determining Progression in Glaucoma Using Visual Fields

Initial Treatment for Open-Angle Glaucoma—Medical, Laser, or Surgical?

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