Initial Treatment for Open-Angle Glaucoma—Medical, Laser, or Surgical?

HSP47 Deletion Inhibits TGF-<i>β</i>1 Stimulation on Proliferation and Collagen Synthesis of Human Tenon Fibroblasts

“…Scarring is a major reason for failure of filtration surgery. Several studies showed that sub conjunctival scarring of the scar tissue formation in a rabbit model of glaucoma filtration surgery [1] [2]. HTF perform an essential role in conjunctival scarring and provide a useful in vitro model of cellular activity during the scarring response [3] [4].…”

HSP47 Deletion Inhibits TGF-<i>β</i>1 Stimulation on Proliferation and Collagen Synthesis of Human Tenon Fibroblasts

“…Scarring is a major reason for failure of filtration surgery. Several studies showed that sub conjunctival scarring of the scar tissue formation in a rabbit model of glaucoma filtration surgery [1] [2]. HTF perform an essential role in conjunctival scarring and provide a useful in vitro model of cellular activity during the scarring response [3] [4].…”

Chemical Insights into Topical Agents in Intraocular Pressure Management: From Glaucoma Etiopathology to Therapeutic Approaches

“…Estimates suggest that topical instillation of pilocarpine can result in IOP reductions ranging from 20 to 30% [ 287 ]. Based on these notions, researchers have investigated the therapeutic potential of pilocarpine against PACG and acute angle closure glaucoma [ 288 ]. The exact therapeutic effects of pilocarpine in treating narrow-angle glaucoma, however, remain controversial.…”

Pilocarpine 1.25% and the changing landscape of presbyopia treatment

“…The impact of Vuity use on pharmacological dilation, whether for dilated fundus exams or cataract surgery is also unclear, however, we expect to have a better understanding as clinical use becomes more widespread. Pilocarpine is an established treatment for pupillary block and acute angle closure glaucoma; however, a paradoxical effect of anterior chamber narrowing has been reported [32][33][34][35]. Anterior displacement of the lens-iris diaphragm and the increase in convexity of the crystalline lens following pilocarpine use has induced rare cases of angle closure glaucoma [36].…”

“…Anterior displacement of the lens-iris diaphragm and the increase in convexity of the crystalline lens following pilocarpine use has induced rare cases of angle closure glaucoma [36]. The concentration of pilocarpine used these cases was 2-4% [32][33][34][35][36]. No cases of angle closure glaucoma were reported in the Gemini 1 or Gemini 2 trials; however, a conservative recommendation would be to avoid treatment in patients with preexisting occludable angles.…”

HSP47 Deletion Inhibits TGF-<i>β</i>1 Stimulation on Proliferation and Collagen Synthesis of Human Tenon Fibroblasts

“…Scarring is a major reason for failure of filtration surgery. Several studies showed that sub conjunctival scarring of the scar tissue formation in a rabbit model of glaucoma filtration surgery [1] [2]. HTF perform an essential role in conjunctival scarring and provide a useful in vitro model of cellular activity during the scarring response [3] [4].…”

Chemical Insights into Topical Agents in Intraocular Pressure Management: From Glaucoma Etiopathology to Therapeutic Approaches

“…Estimates suggest that topical instillation of pilocarpine can result in IOP reductions ranging from 20 to 30% [ 287 ]. Based on these notions, researchers have investigated the therapeutic potential of pilocarpine against PACG and acute angle closure glaucoma [ 288 ]. The exact therapeutic effects of pilocarpine in treating narrow-angle glaucoma, however, remain controversial.…”

Pilocarpine 1.25% and the changing landscape of presbyopia treatment

“…The impact of Vuity use on pharmacological dilation, whether for dilated fundus exams or cataract surgery is also unclear, however, we expect to have a better understanding as clinical use becomes more widespread. Pilocarpine is an established treatment for pupillary block and acute angle closure glaucoma; however, a paradoxical effect of anterior chamber narrowing has been reported [32][33][34][35]. Anterior displacement of the lens-iris diaphragm and the increase in convexity of the crystalline lens following pilocarpine use has induced rare cases of angle closure glaucoma [36].…”

“…Anterior displacement of the lens-iris diaphragm and the increase in convexity of the crystalline lens following pilocarpine use has induced rare cases of angle closure glaucoma [36]. The concentration of pilocarpine used these cases was 2-4% [32][33][34][35][36]. No cases of angle closure glaucoma were reported in the Gemini 1 or Gemini 2 trials; however, a conservative recommendation would be to avoid treatment in patients with preexisting occludable angles.…”

HSP47 Deletion Inhibits TGF-<i>β</i>1 Stimulation on Proliferation and Collagen Synthesis of Human Tenon Fibroblasts

“…Scarring is a major reason for failure of filtration surgery. Several studies showed that sub conjunctival scarring of the scar tissue formation in a rabbit model of glaucoma filtration surgery [1] [2]. HTF perform an essential role in conjunctival scarring and provide a useful in vitro model of cellular activity during the scarring response [3] [4].…”

Chemical Insights into Topical Agents in Intraocular Pressure Management: From Glaucoma Etiopathology to Therapeutic Approaches

“…Estimates suggest that topical instillation of pilocarpine can result in IOP reductions ranging from 20 to 30% [ 287 ]. Based on these notions, researchers have investigated the therapeutic potential of pilocarpine against PACG and acute angle closure glaucoma [ 288 ]. The exact therapeutic effects of pilocarpine in treating narrow-angle glaucoma, however, remain controversial.…”

Pilocarpine 1.25% and the changing landscape of presbyopia treatment

“…The impact of Vuity use on pharmacological dilation, whether for dilated fundus exams or cataract surgery is also unclear, however, we expect to have a better understanding as clinical use becomes more widespread. Pilocarpine is an established treatment for pupillary block and acute angle closure glaucoma; however, a paradoxical effect of anterior chamber narrowing has been reported [32][33][34][35]. Anterior displacement of the lens-iris diaphragm and the increase in convexity of the crystalline lens following pilocarpine use has induced rare cases of angle closure glaucoma [36].…”

“…Anterior displacement of the lens-iris diaphragm and the increase in convexity of the crystalline lens following pilocarpine use has induced rare cases of angle closure glaucoma [36]. The concentration of pilocarpine used these cases was 2-4% [32][33][34][35][36]. No cases of angle closure glaucoma were reported in the Gemini 1 or Gemini 2 trials; however, a conservative recommendation would be to avoid treatment in patients with preexisting occludable angles.…”