Point-of-care COPD diagnostics: biomarkers, sampling, paper-based analytical devices, and perspectives

He, Guozhen; Dong, Tao; Yang, Zhaochu; Branstad, Are; Huang, Lan; Jiang, Zhuangde

doi:10.1039/d1an01702k

Cited by 12 publications

(14 citation statements)

References 219 publications

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“…Under physiological conditions, the saliva crystals have a branched shape due to the presence in the oral fluid of the micelles Са3 (РO4) 2, protected by the aggregation of mucin with a branched form. Mucins participate in the transepithelial transport of ions (Na +, K +, CI-), as well as in the biocrystallization process in which Са2 + ions are involved, constituting the organic matrix that regulates the volume and configuration of crystalline structures and the În decursul ultimilor decenii s-au făcut primii pași în studierea manifestărilor diverselor maladii în organizarea structurală a FO [1,2,4,11,13,20]. Luând în considerație conceptul cristalografiei clasice, în diagnosticul timpuriu sau prenozologic al afecțiunilor stomatologice și al maladiilor sistemice, s-a propus aplicarea metodei cristalografice de cercetare a celui mai accesibil lichid biologic -a fluidului oral [5,17].…”

Section: Discussionunclassified

“…Studiul modificărilor cristalografice ale FO a fost efectuat după metoda elaborată de Leous P. Fluidul of the studied pathology [1,2,4]. Human body fluids are widely used in laboratory diagnosis.…”

Section: Materiale șI Metodeunclassified

“…According to the objectives of evidence-based medicine, there is a need to apply clinical and laboratory investigation methods that ensure the obtaining of high-precision quantitative parameters for the argumentation and rational selection of the treatment studiate [1,2,4]. Lichidele organismului uman sunt utilizate pe scară largă în diagnosticul de laborator.…”

Section: Introductionmentioning

confidence: 99%

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The relationship between oral fluid microcrystalization and child affection by dental caries

Dimitriu¹,

Spinei²

2023

JSM

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The aim of the paper was to study the microcrystallization of oral fluid and to affect children through tooth decay. 148 children between the ages of 7 and 10 were clinically examined. Indices of tooth decay frequency and carious experience were estimated. Salivary flow rate, saliva pH and salivary buffering capacity were studied using the Saliva–Check Buffer Kit, GC. The study of microcrystallization of oral fluid (OF) was performed by the method of drop dehydration. The study was performed in accordance with the requirements of the Code of Ethics in scientific research. A direct relationship was established between intense carious activity and the decrease of the degree of microcrystallization of OF. Conclusions: the main advantages of the research of the crystallographic properties of OF are the non–invasiveness, the simplicity of the realization and the accessibility of the sampling of the studied substrate, thus offering new perspectives in clinical trials. The study of OF microcrystallization in children with dental caries elucidated a series of markers of changes in the oral cavity that can be used later in screening research, in dental practice, in the development of preventive measures and evaluation of their effectiveness.

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Section: Discussionunclassified

Section: Materiale șI Metodeunclassified

Section: Introductionmentioning

confidence: 99%

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The relationship between oral fluid microcrystalization and child affection by dental caries

Dimitriu¹,

Spinei²

2023

JSM

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“…Finally, not to be underestimated are the indirect costs of the disease (i.e., within the profile of COPD/asthma patients) due to the loss of productivity and premature retirement of patients. The importance of these aspects is highlighted by the vast amount of literature dealing with the magnitude of resources needed to treat patients with these severe disorders, and with the public health measures taken by the world governments to face their impact on human psychology, the educational system, and the global economy [ 74 , 75 , 76 , 77 , 78 ]. How can proteomics alleviate these issues?…”

Section: Exploring the Role Of Biomarkersmentioning

confidence: 99%

Proteomic Analysis of Human Sputum for the Diagnosis of Lung Disorders: Where Are We Today?

Iadarola

Viglio

2022

IJMS

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The identification of markers of inflammatory activity at the early stages of pulmonary diseases which share common characteristics that prevent their clear differentiation is of great significance to avoid misdiagnosis, and to understand the intrinsic molecular mechanism of the disorder. The combination of electrophoretic/chromatographic methods with mass spectrometry is currently a promising approach for the identification of candidate biomarkers of a disease. Since the fluid phase of sputum is a rich source of proteins which could provide an early diagnosis of specific lung disorders, it is frequently used in these studies. This report focuses on the state-of-the-art of the application, over the last ten years (2011–2021), of sputum proteomics in the investigation of severe lung disorders such as COPD; asthma; cystic fibrosis; lung cancer and those caused by COVID-19 infection. Analysis of the complete set of proteins found in sputum of patients affected by these disorders has allowed the identification of proteins whose levels change in response to the organism’s condition. Understanding proteome dynamism may help in associating these proteins with alterations in the physiology or progression of diseases investigated.

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“…However, they have stimulated the search for novel biomarkers that may complement the clinical information currently gathered from physical examination, lung function tests, and imaging procedures [ 3 ]. The established role of infection, inflammation, and immunity in the pathophysiology and the clinical progression of COPD has led to the identification of a number of biomarkers within these pathways, e.g., eosinophils, procalcitonin, neutrophil elastase, and serum amyloid A, which can be characterised from different biological matrices, blood, saliva, or sputum [ 3 , 4 , 5 , 6 ]. Though some of these biomarkers, e.g., eosinophils and procalcitonin, appear particularly promising to enhance clinical and therapeutic decisions in patients with stable COPD and AECOPD [ 7 ], the availability of additional biomarkers from routine laboratory tests might also further improve patient care in those settings that have limited access to expensive and complex analytical facilities.…”

Section: Introductionmentioning

confidence: 99%

The Emerging Clinical Significance of the Red Cell Distribution Width as a Biomarker in Chronic Obstructive Pulmonary Disease: A Systematic Review

Zinellu

Mangoni

2022

JCM

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There is an intense focus on the identification of novel biomarkers of chronic obstructive pulmonary disease (COPD) to enhance clinical decisions in patients with stable disease and acute exacerbations (AECOPD). Though several local (airway) and circulatory inflammatory biomarkers have been proposed, emerging evidence also suggests a potential role for routine haematological parameters, e.g., the red cell distribution width (RDW). We conducted a systematic literature search in PubMed, Web of Science, and Scopus, from inception to April 2022, for articles investigating the diagnostic and prognostic role of the RDW in stable COPD and AECOPD. The risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. Significant associations between the RDW and the presence and severity of disease, outcomes (mortality, hospital readmission), and other relevant clinical parameters (right heart failure, pulmonary arterial hypertension) were reported in 13 out of 16 studies in stable COPD (low risk of bias in 11 studies), and 17 out of 21 studies of AECOPD (low risk of bias in 11 studies). Pending further research, our systematic review suggests that the RDW might be useful, singly or in combination with other parameters, for the diagnosis and risk stratification of patients with stable COPD and AECOPD (PROSPERO registration number: CRD42022348304).

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Point-of-care COPD diagnostics: biomarkers, sampling, paper-based analytical devices, and perspectives

Abstract: Chronic Obstructive pulmonary disease (COPD) has become the third leading causes of global death. Insufficiency in early-diagnosis and treatment of COPD, especially COPD exacerbation, leads to tremendous economic burden and...

Cited by 12 publications

References 219 publications

The relationship between oral fluid microcrystalization and child affection by dental caries

The relationship between oral fluid microcrystalization and child affection by dental caries

Proteomic Analysis of Human Sputum for the Diagnosis of Lung Disorders: Where Are We Today?

The Emerging Clinical Significance of the Red Cell Distribution Width as a Biomarker in Chronic Obstructive Pulmonary Disease: A Systematic Review

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