Point- and frequency-specific response of the testicular artery to abdominal electroacupuncture in humans

Cakmak, Yusuf Özgür; Akpınar, İhsan; Ekinci, Gazanfer; Bekiroğlu, Nural

doi:10.1016/j.fertnstert.2007.08.013

Cited by 42 publications

(47 citation statements)

References 17 publications

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“…was selected for application of Ac/EAc, based on the study of Cakmak et al 8 . We used the same electrical current intensities and frequencies for acupoint stimulation, hoping to attain the same effects observed in humans in a rat model.…”

Section: Discussionmentioning

confidence: 99%

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Protective effects of abdominal electroacupuncture on oxidative stress and inflammation due to testis torsion/detorsion in rats

Acioli

Albuquerque²,

Guimarães³

et al. 2014

Acta Cir. Bras.

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Conception, design, intellectual and scientific content of the study, critical revision, final approval of the manuscript. ABSTRACT PURPOSE:To evaluate the effects of acupuncture (Ac) and electroacupuncture (EAc) on oxidative stress and inflammation in testis torsion/detorsion (T/D) model in rats. METHODS:Thirty male Wistar rats were randomized into five groups. G1 Group (Sham) served as control. The remaining groups were submitted to spermatic cord torsion (720°) for 3 hours, followed by detorsion and reperfusion for 4 hours. Before detorsion G3, G4 and G5 rats were treated with Ac, EAc 2Hz and EAc 10 Hz, respectively, applied to acupoint Gulai (S-29) bilaterally under anesthesia for 5 minutes. Next, the testes were detorsioned and reperfused for 4 hours. Afterwards, blood samples and the right testis were collected for biochemical assays: reduced Glutathione (GSH), Malonaldehyde (MDA), Myeloperoxidase (MPO). RESULTS:EAc stimulation (2 and 10 Hz) promoted significant increase in concentrations of GSH in plasma and testis of G4-G5 rats, compared with G1. There was significant increase of tissue MDA in groups G4-G5 and plasma MDA in all groups, compared with G1.There was a significant reduction in MPO activity in groups G4-G5 compared with G1. CONCLUSION:Electroacupuncture stimulation (2 and 10 Hz) attenuates oxidative stress and inflammatory response in rats subjected to testicular torsion/detorsion. Key words: Spermatic Cord Torsion. Ischemia. Reperfusion Injury. Electroacupuncture. Rats. Protective effects of abdominal electroacupuncture on oxidative stress and inflammation due to testis torsion/detorsion in rats

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Section: Discussionmentioning

confidence: 99%

“…Time of stimulation and the selection of acupoint were based on work by Cakmak et al 8 . In the rat, the acupoint S-25 is located lateral to the umbilical scar at the midpoint between the navel and the nipple line 15 .…”

Section: Application Of Acupuncture/eletroacupuncturementioning

confidence: 99%

Protective effects of abdominal electroacupuncture on oxidative stress and inflammation due to testis torsion/detorsion in rats

Acioli

Albuquerque²,

Guimarães³

et al. 2014

Acta Cir. Bras.

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“…He et al [35] demonstrated AP stimulations were increased the ovarian expression of vascular endothelial growth factor (VEGF), VEGF mRNA and luteinizing hormone receptor (LHR) mRNA in rats. Besides EAP increased the blood flow of the target organs in genital tract [18,45] . AP shows this effect by reflecting the ovarian sympathetic nerves, and systemic circulation respectively [46] .…”

Section: Discussionmentioning

confidence: 97%

“…Effect of AP on fertility is explained with three different mechanisms: 1) AP may mediate the release of neurotransmitters to stimulate the secretion of the gonadotropin-releasing hormone (GnRH) 2) AP may stimulate blood flow to the uterus by inhibiting uterine central sympathetic nerve activity and 3) AP may stimulate the production of endogenous opioids, which may inhibit the central nervous system outflow and the biological stress response [12] . Thus this method has been used in treating different reproductive disorders such as; pseudopregnancy, silent heat, repeat breeder syndrome, cystic ovaries, uterine prolapse, retained fetal membranes [13] , polycystic ovaries [14,15] , induction of cyclicity in anestrus mares [16] , induction of ovulation [17] , and increasing the blood flow to uterus and ovaries [18] . AP stimulation of certain points historically associated with reproduction significantly alters plasma levels of sex hormones, such as Luteinizing hormone (LH), Folliclestimulating hormone (FSH), estradiol (E 2 ) and progesterone (P 4 ) [19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

Sütçü İneklerde Akupunktur Stimülasyonlarının Korpus Luteum Büyüklüğü, Kan Akımı ve Progesteron Değerleri Üzerine Etkilerinin İncelenmesi

Küçükaslan¹,

Kaya²,

Wollgarten³

et al. 2015

Kafkas Univ Vet Fak Derg

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In this study, effect of acupuncture (AP) on the luteal size (LS), luteal blood flow (LBF) and progesterone (P4) levels were investigated in the presence of corpus luteum (CL) in cows. Seven days after 14-days interval PGF2α estrus synchronization protocol, CL positive animals were assigned either to a control group (AP-, n=10) or to an AP group (AP+, n=10) stimulated by using B22 and B23 sensitive acupoints. LS and LBF examinations were carried out before the stimulation (0h) and at 1st, 3rd, 6th hour on d7 and thereafter on d9, d10, d11, d12 and d13 following the AP stimulation in each group with a portable color Doppler ultrasonography. Blood samples for P4 measurement were collected during each examination. There was no significant difference in LS, LBF, or P4 mean values between groups. However, LBF significantly increased at 6h after stimulation (P<0.05) in AP+ group but it increased at d11 in AP-group (P<0.05). The significant increase in LS was observed earlier in AP+ group (on d9; P<0.01) than AP-(on d11; P<0.05). Serum P4 concentrations increased at 3h, d9 and d10 in AP+ group (P<0.05), however a significant difference was only observed at 3h in AP-group (P<0.05). In conclusion, AP stimulation induces earlier increases in LS, LBF and P4 parameters in cows during luteal phase. Keywords: Acupuncture, Cow, Luteal size, Luteal blood flow, Progesterone Sütçü İneklerde Akupunktur Stimülasyonlarının Korpus Luteum Büyüklüğü, Kan Akımı ve Progesteron Değerleri Üzerine Etkilerinin İncelenmesi ÖzetBu çalışmada akupunkturun (AP) ineklerde korpus luteum (CL) varlığında luteal büyüklük (LS), luteal kan akımı (LBF) ve progesteron (P4) seviyeleri üzerindeki etkisi incelendi. 14 gün aralıklı PGF2α östrus senkronizasyon protokolünden 7 gün sonra, CL tespit edilen hayvanlar kontrol (AP-, n=10) ve duyarlı B22 ve B23 kullanılarak stimüle edilen akupunktur gruplarına ayrıldı (AP+, n=10). LS ve LBF incelemeleri taşınabilir bir renkli Doppler ultrasonografi ile 7. günde stimülasyon öncesi (0. saat), izleyen 1, 3, 6. saatler ve 9, 10, 11, 12 ve 13. günlerde yapıldı. Her muayenede P4 ölçümleri için kan örnekleri alındı. Gruplar arasında LS, LBF ve P4 ortalama değerleri farklı değildi. Bununla birlikte, LBF AP+ grubunda stimülasyon sonrası 6. saatte (P<0.05) ancak AP-grubunda 11. günde arttı (P<0.05). LS'deki önemli artış ise AP+ grubunda (9. gün; P<0.01), AP-grubuna göre (11. gün; P<0.05) daha erken gözlendi. Serum P4 konsantrasyonları AP+ grubunda 3. saat, 9. gün ve 10. günde artış gösterdi (P<0.05). Ancak AP-grubunda sadece 3. saatte önemli değişim gözlendi (P<0.05). Sonuç olarak, luteal faz sırasında akupunktur stimülasyonu LS, LBF ve P4 değerlerinde daha erken artışa neden olmaktadır.

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“…Therefore, electrical stimulation may be an efective alternative to medications to regulate the HPG axis [67]. Another clinical trial in humans showed that 10-Hz EA stimulation of the abdominal acupuncture points ST-29 (guilai) increased testicular blood low (TBF), but simple needle insertion and 2-Hz EA stimulation did not [68]. The combination of acupuncture and moxibustion treatment has also been shown to increase the percentage of normal-form sperm in infertile patients with oligoastenoteratozoospermia in a prospective, controlled, and blinded study, but the mechanisms remain unknown [69].…”

Section: Male Infertilitymentioning

confidence: 99%

Complementary and Alternative Therapy with Traditional Chinese Medicine for Infertility

Liao¹,

Hu²,

Hung³

2017

Chinese Medical Therapies for Diabetes, Infertility, Silicosis and the Theoretical Basis

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Infertility results in a country with a low birth rate and an aging population, and thus there is vested interest in treating this problem by using both complementary and alternative therapies, in addition to conventional western medicine. Traditional Chinese medicine (TCM) has been widely used for healthcare in the Eastern world for thousands of years. This chapter describes the evidence to support the role of TCM in the management of male and female infertility.

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Point- and frequency-specific response of the testicular artery to abdominal electroacupuncture in humans

Cited by 42 publications

References 17 publications

Protective effects of abdominal electroacupuncture on oxidative stress and inflammation due to testis torsion/detorsion in rats

Protective effects of abdominal electroacupuncture on oxidative stress and inflammation due to testis torsion/detorsion in rats

Sütçü İneklerde Akupunktur Stimülasyonlarının Korpus Luteum Büyüklüğü, Kan Akımı ve Progesteron Değerleri Üzerine Etkilerinin İncelenmesi

Complementary and Alternative Therapy with Traditional Chinese Medicine for Infertility

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