Podosomes at a glance

The metastatic process, i.e. the dissemination of cancer cells throughout the body to seed secondary tumors at distant sites, requires cancer cells to leave the primary tumor and to acquire migratory and invasive capabilities. In a process of epithelial-mesenchymal transition (EMT), besides changing their adhesive repertoire, cancer cells employ developmental processes to gain migratory and invasive properties that involve a dramatic reorganization of the actin cytoskeleton and the concomitant formation of membrane protrusions required for invasive growth. The molecular processes underlying such cellular changes are still only poorly understood, and the various migratory organelles, including lamellipodia, filopodia, invadopodia and podosomes, still require a better functional and molecular characterization. Notably, direct experimental evidence linking the formation of migratory membrane protrusions and the process of EMT and tumor metastasis is still lacking. In this review, we have summarized recent novel insights into the molecular processes and players underlying EMT on one side and the formation of invasive membrane protrusions on the other side.

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“…3 a). The multimeric adhesive ring complex is connected to the actin core via radial actin filaments [188][189][190][191].…”

Section: Podosomes and Invadopodiamentioning

confidence: 99%

EMT, the cytoskeleton, and cancer cell invasion

Yilmaz

Christofori

2009

Cancer Metastasis Rev

1,505

1,321

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“…Podosomes are typically formed in monocytic cells (monocytes, macrophages, dendritic cells and osteoclasts), endothelial cells and smooth muscle cells, whereas invadopodia are mostly found in cancer cells (Buccione et al, 2004;Linder and Kopp, 2005;Ayala et al, 2006;Gimona and Buccione, 2006;Weaver, 2006;Linder, 2007). Invadosomes in fibroblasts that have been transformed with tyrosine kinases such as Src show features of both podosomes and invadopodia, and their exact identity is currently unclear.…”

Section: Open Questions In Invadosome Biologymentioning

confidence: 99%

“…Signaling downstream of integrins is mediated by various cytoskeleton-associated kinases such as protein kinase C (PKC), phosphoinositide 3-kinase (PI3K), Src or focal adhesion kinase (FAK) (reviewed by Linder and Kopp, 2005). Src, in particular, seems to be a master switch for invadosome formation (Cortesio et al, 2008;Destaing et al, 2008;Oikawa et al, 2008), and inhibition of Src-family proteins using inhibitors such as PP2 (Linder et al, 2000a) has proven to be a useful tool for their manipulation.…”

Section: The Cytoskeletal Backbonementioning

confidence: 99%

Invadosomes at a glance

Linder

2009

Journal of Cell Science

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145

171

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“…Furthermore, both these structures are transient and regulate the spatial and temporal communication between cells. Podosomes (reviewed by Linder and Kopp, 2005;Linder, 2007) and invadopodia (Vignjevic and Montagnac, 2008) are known to form adhesion structures between the filopodia and the extracellular matrix (ECM) and to be involved in matrix degradation that ultimately can lead to invasion. Both of these structures have recently been compared to the immunological synapse (reviewed by Wernimont et al, 2008).…”

Section: Comparision Of Transient Adhesive Structures: the Furmas Immentioning

confidence: 99%

FuRMAS: triggering myoblast fusion in Drosophila

Önel

Renkawitz‐Pohl

2009

Developmental Dynamics

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In Drosophila, as in mammals, myoblast fusion is fundamental for development. This fusion process has two distinct phases that share common ultrastructural features and at least some molecular players between Drosophila and vertebrates. Here, we integrate the latest data on the key molecular players and ultrastructural features found during myoblast fusion into a new working model to explain this fundamental cellular process. At cell-cell contact sites, a protein complex (

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Podosomes at a glance

Cited by 189 publications

References 36 publications

EMT, the cytoskeleton, and cancer cell invasion

EMT, the cytoskeleton, and cancer cell invasion

Invadosomes at a glance

FuRMAS: triggering myoblast fusion in Drosophila

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