Invadosomes at a glance

Linder, Stefan

doi:10.1242/jcs.032631

Cited by 147 publications

(178 citation statements)

References 73 publications

(77 reference statements)

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“…Their assembly is strongly dependent on RhoGTPase activities (Linder, 2009). Podosomes consist of a densely packed actin core and actin-regulatory proteins [gelsolin, cortactin, Arp2/3 (actin-related protein 2/3), WASP (Wiskott-Aldrich syndrome protein)/N-WASP (neuronal WASP)] surrounded by a ring of components commonly found in focal adhesion structures such as vinculin, integrins and signalling proteins.…”

Section: Introductionmentioning

confidence: 99%

Sodium fluoride induces podosome formation in endothelial cells

Tatin

Grise

Reuzeau

et al. 2010

Biology of the Cell

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Background information. Fluoride is a well‐known G‐protein activator. Exposure of cultured cells to its derivatives results in actin cytoskeleton remodelling. Podosomes are actin‐based structures endowed with adhesion and matrix‐degradation functions. This study investigates actin cytoskeleton reorganization induced by fluoride in endothelial cells.Results. Treatment of cultured endothelial cells with sodium fluoride (NaF) results in a rapid and potent stimulation of podosome formation. Furthermore, we show that Cdc42 (cell‐division cycle 42), Rac1 and RhoA activities are stimulated in NaF‐treated cells. However, podosome assembly is dependent on Cdc42 and Rac1, but not RhoA. Although the sole activation of Cdc42 is sufficient to induce individual podosomes, a balance between RhoGTPase activities regulates podosome formation in response to NaF, which in this case are often found in groups or rosettes. As in other models, podosome formation in endothelial cells exposed to NaF also involves Src. Finally, we demonstrate that NaF‐induced podosomes are fully competent for matrix protein degradation.Conclusions. Taken together, our findings establish NaF as a novel inducer of podosomes in endothelial cells in vitro.

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Section: Introductionmentioning

confidence: 99%

Sodium fluoride induces podosome formation in endothelial cells

Tatin

Grise

Reuzeau

et al. 2010

Biology of the Cell

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“…The contribution of invadopodia to digestive cancer is an evolving area of research [66]. Invadopodia are cell-matrix contacts, similar to focal adhesions, established in the context of "invading" cellular protusions [66].…”

Section: Remodeling Of the Bm And Ecm In Cancermentioning

confidence: 99%

“…Invadopodia are cell-matrix contacts, similar to focal adhesions, established in the context of "invading" cellular protusions [66]. Invadopodia can promote ECM proteolysis through their associated proteases, particularly MT1-MMP [67], and thus have been implicated in cancer invasion, both neoplastic cells moving out and cancer-associated fibroblasts moving in [66]. The cause and consequences of invadopodia unites many of the key themes from the discussion above, including ECM remodeling, matrix proteases, cell motility and mechanical forces [66].…”

Section: Remodeling Of the Bm And Ecm In Cancermentioning

confidence: 99%

“…Invadopodia can promote ECM proteolysis through their associated proteases, particularly MT1-MMP [67], and thus have been implicated in cancer invasion, both neoplastic cells moving out and cancer-associated fibroblasts moving in [66]. The cause and consequences of invadopodia unites many of the key themes from the discussion above, including ECM remodeling, matrix proteases, cell motility and mechanical forces [66]. Whilst, invadosomes have been examined primarily in 2-dimensional cell culture, there is now evidence for their role in 3-dimensional cell culture studies [68].…”

Section: Remodeling Of the Bm And Ecm In Cancermentioning

confidence: 99%

“…Whilst, invadosomes have been examined primarily in 2-dimensional cell culture, there is now evidence for their role in 3-dimensional cell culture studies [68]. Their in vivo contribution to the digestive cancer microenvironment, however, remains to be established [66].…”

Section: Remodeling Of the Bm And Ecm In Cancermentioning

confidence: 99%

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The extracellular components of the cancer microenvironment play a critical role in tumor initiation, progression and invasion. In this review we examine the normal formation and function of the basement membrane and extracellular matrix. We characterize the interactions between the matrix and the epithelium and explore the causes and consequences of the extracellular remodeling that accompanies carcinogenesis. Finally, we address the therapeutic possibilities of incorporating matrix as well as epithelial strategies in the management of digestive cancer.

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Invadosomes at a glance

Cited by 147 publications

References 73 publications

Sodium fluoride induces podosome formation in endothelial cells

Sodium fluoride induces podosome formation in endothelial cells

The Extracellular Matrix in Digestive Cancer

The relationship between mesenchymal stromal cells and endothelial cells

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