Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives

Intérêt des lignanes dans la prévention et le traitement de cancers

“…Dans cette optique, le genre Linum apparaît comme un bon modèle pour la poursuite des études sur les lignanes. En effet, des lins sauvages tels que Linum album ou Linum flavum (Figure 2) accumulent respectivement de la PTOX et de la 6-méthoxy-PTOX [43]. La voie du génie génétique, qui nécessite le clonage des gènes codant les enzymes limitantes de cette voie métabolique, couplée à des méthodes de supplémentation en précurseurs simples pourrait également offrir de nouvelles perspectives.…”

Avaliação da atividade antimicobacteriana da lignana diidrocubebina extraída da Piper cubeba e de seus derivados semissintéticos

“…Neste sentido, a necessidade de novos agentes antimicrobianos que apresentem menos efeitos colaterais e menor tempo de tratamento tem levado pesquisadores a focarem suas pesquisas em moléculas de ocorrência natural assim como tem sido feito para muitas outras doenças (Verg et al, 1998, Damayanthi & Lown 1998Gordaliza et al, 2004;Akinyemi et al, 2005;Dey et al, 2014). Garcí et al (2012) publicaram um artigo de revisão sobre produtos naturais com atividade in vitro sobre cepas sensíveis e resistentes de Mycobacterium.…”

Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity

“…Due to these biological activities, lignans, and especially neolignans, have been the subject of numerous studies aimed at developing better and safer anticancer drugs. 17 In the development of new inhibitors, natural products such as neolignans from Licaria chrysophylla and Licaria aurea can be a valuable source of inhibitors and may also serve as a suitable lead for the production of semisynthetic active agents. One benzofuranoid-type lignan (1) and six neolignans (2-7) were isolated from Licaria chrysophylla [18][19][20][21] while the tetrahydrofuran-type neolignan grandisin (8) was isolated from Licaria aurea (Figure 1).…”