Intérêt des lignanes dans la prévention et le traitement de cancers

Lamblin, Frédéric; Hano, Christophe; Fliniaux, Ophélie; Mesnard, François; Fliniaux, Marc‐André; Lainé, Éric

doi:10.1051/medsci/2008245511

Cited by 19 publications

(13 citation statements)

References 37 publications

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“…Flaxseed or pure lignans showed anticarcinogenic effects in many types of cancer, and flaxseed oil could inhibit the growth and development of tumors in the breast of laboratory animals (Lamblin et al, 2008). The influence of flaxseed lignans and oil components in reducing breast cancer risk and tumor growth was reviewed (Mason and Thompson, 2014).…”

Section: The Statistical Analysismentioning

confidence: 99%

Preparation of Bioactive Kefir with Added Flaxseed (Linum usitatissimumL.) Extract

Jeong¹,

Kim²,

Chon³

et al. 2017

J. Milk Sci. Biotechnol.

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Flaxseed (Linum usitatissimum L.) is an important food, oil, and fiber crop of the family Linaceae. Although flaxseed has been consumed as a food ingredient for several centuries, its nutritional benefits have not yet been completely established. Flaxseed is a good source of lignans, nonstarch polysaccharides, and high-quality proteins. Hence, in this study, we aimed to prepare a bioactive kefir containing flaxseed and to examine the physicochemical characteristics of kefir containing different concentrations of flaxseed. We investigated the pH, and sensory evaluation of bioactive Kefir containing different concentrations of flaxseed. We investigated the pH, total anthocyanins (TAs), and sensory evaluation of bioactive Kefir containing different concentrations of flaxseed. The pH of this bioactive kefir decreased, whereas the TA content increased with increasing incubation time; however, these parameters were not affected by the amount of added flaxseed. As the addition rate of flaxseed increased, the scores for overall acceptability, texture, color, flavor, and taste in sensory evaluations were generally the same as or lower than the control. There were no significant differences in overall acceptability, texture, color, flavor, and taste between the control and treated groups. Therefore, further studies are needed to develop methods for production of health-improving kefir as a dietary supplement based on the functional properties of flaxseed.

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Section: The Statistical Analysismentioning

confidence: 99%

Preparation of Bioactive Kefir with Added Flaxseed (Linum usitatissimumL.) Extract

Jeong¹,

Kim²,

Chon³

et al. 2017

J. Milk Sci. Biotechnol.

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“…Lignans are mainly described as defensive molecules with antifungal and antibacterial properties [11,12]. One of the main interests in lignans is due to Lignan classification in eight groups their preventive and/or curative, biological activities towards promoting human health [13][14][15][16].…”

Section: Atlmentioning

confidence: 99%

Bioproduction of Anticancer Podophyllotoxin and Related Aryltretralin-Lignans in Hairy Root Cultures of Linum Flavum L.

Mikac

Markulin

Drouet

et al. 2020

Reference Series in Phytochemistry

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Podophyllotoxin (PPT) is the unique natural precursor of Etoposide, a topoisomerase II inhibitor drug, used in more than a dozen anticancer chemotherapy treatments. Etoposide is appearing on the list of essential medicines of the World Health Organization. PPT is still exclusively extracted from the rhizome of Podophyllum species, its main natural source. The supply of Podophyllum hexandrum plants is limited, since the occurrence of these plant species is scarce, collection is destructive, and the plants need a long regeneration period. As a consequence, this species is now endangered and listed on Appendix II of the Convention on International Trading of Endangered Species. Chemical synthesis of PPT is difficult due to the presence of four contiguous chiral centers and the presence of a base sensitive trans-lactone moiety. Alternatives are being actively searched, but so far, no wild plants have been described with similar PPT production capacity as compared to Podophyllum. However, several plants producing PPT or other related aryltetralin lignans (ATL) have been identified in recent decades, including the Linaceae. Given its high lignan accumulation capacity, Linum flavum is considered a promising alternative source of PPT and other related ATL. However, unlike the common flax L. usitatissimum, L. flavum has a low agricultural potential (e.g., slow growth and dehiscence of fruits). Therefore, in vitro cultures of plant cells and/or tissues provide an interesting alternative to whole L. flavum plants for the production of these valuable ATL. In particular, L. flavum hairy roots (HRs) accumulate high levels of ATL and it is also possible to further increase this ATL accumulation by the selection of the best genotype, optimization of cultures media and conditions and choice of carbon sources, use of plant growth regulators, elicitor treatments, or precursors' addition. To date, the ATL accumulation levels can still be perceived insufficient for L. flavum HRs before being used as a commercially viable biotechnological production system. To reach this goal, a better knowledge of the mechanisms that regulate the metabolic flux of intermediates in the different branches of the ATL metabolic pathway will be an important prerequisite to direct the biosynthesis toward the production of a high amount of the desired PPT. In the future, metabolic engineering aiming at constructing the PPT pathway in a heterologous host is very appealing, but for that approach in-depth knowledge of the biosynthetic pathway toward PPT and other related ATL is necessary.

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“…Flax (Linum usitatissimum L.) is one of the oldest annual crops and presents numerous benefits to human health [1][2][3][4][5]. Its average production of 1.6 million metric tons of flax produced worldwide shows that its economic importance is still relevant [6].…”

Section: Introductionmentioning

confidence: 99%

“…Among the nutritionally important components of flaxseed omega-3 fatty acids, polyphenols (in particular, lignans), proteins and dietary fibers are included [7]. Flax has also been served for medicinal purposes for a long time, as it contains medicinally important lignans, which demonstrate pronounced antioxidant and phytoestrogenic activities [1][2][3]. The pharmacologically active lignans in flaxseeds include secoisolariciresinol (SECO), lariciresinol diglucoside (LDG) and secoisolariciresinol diglucoside (SDG) (Figure 1), which represent over 95% of the total lignan components from flaxseeds [8,9].…”

Section: Introductionmentioning

confidence: 99%

Feasible Production of Lignans and Neolignans in Root-Derived In Vitro Cultures of Flax (Linum usitatissimum L.)

Anjum

Komal

Drouet

et al. 2020

Plants

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Flax lignans and neolignans impart health benefits, particularly in treating different types of cancers, due to their strong phytoestrogenic and antioxidant properties. The present study enhances the comprehension on the biosynthesis of antioxidant lignans and neolignans in root-derived in vitro cultures of flax (both callus and adventitious root). The results presented here clearly showed that the adventitious root culture efficiently produced a higher amount of lignans (at day 40) and neolignans (at day 30) than callus culture of flax. High performance liquid chromatography (HPLC) analysis revealed that the accumulations of secoisolariciresinol diglucoside (SDG, 5.5 mg g−1 DW (dry weight)) and dehydrodiconiferyl alcohol glucoside (DCG, 21.6 mg/g DW) were 2-fold higher, while guaiacylglycerol-β-coniferyl alcohol ether glucoside (GGCG, 4.9 mg/g DW) and lariciresinol glucoside (LDG, 11.9 mg/g DW) contents were 1.5-fold higher in adventitious root culture than in callus culture. Furthermore, the highest level of total phenolic production (119.01 mg/L), with an antioxidant free radical scavenging activity of 91.01%, was found in adventitious root culture at day 40, while the maximum level of total flavonoid production (45.51 mg/L) was observed in callus culture at day 30 of growth dynamics. These results suggest that adventitious root culture can be a good candidate for scaling up to industrial level to commercially produce these pharmacologically and nutritionally valuable metabolites.

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Intérêt des lignanes dans la prévention et le traitement de cancers

Cited by 19 publications

References 37 publications

Preparation of Bioactive Kefir with Added Flaxseed (Linum usitatissimumL.) Extract

Preparation of Bioactive Kefir with Added Flaxseed (Linum usitatissimumL.) Extract

Bioproduction of Anticancer Podophyllotoxin and Related Aryltretralin-Lignans in Hairy Root Cultures of Linum Flavum L.

Feasible Production of Lignans and Neolignans in Root-Derived In Vitro Cultures of Flax (Linum usitatissimum L.)

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