Podophyllin 0.5% or 2.0% v podophyllotoxin 0.5% for the self treatment of penile warts: a double blind randomised study.

White, David; Billingham, C; Chapman, Shavaun; Drake, Susan M.; Jayaweera, Dushyantha; Jones, Stephen A.; Opaneye, A A; Temple, Claire

doi:10.1136/sti.73.3.184

Cited by 7 publications

(14 citation statements)

References 4 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is a plant resin that causes an inflammatory tissue reaction, which leads to keratinocyte necrosis (8) and attenuation of cells in mitosis (9). It has a shelf life of at least 3 months, but active ingredient concentrations begin to vary as the preparation ages (10). Podophyllin is applied in the physician's office directly to the lesion as a 10–25% solution, washed off 1–4 h later, and repeated once per week for 4–6 weeks.…”

Section: External Genital Wartsmentioning

confidence: 99%

“…Podophyllin is moderately effective in the treatment of EGWs, but recurrence rates are highly variable (Table 1). In randomized controlled trials, podophyllin monotherapy yields clearance rates of 41–77% and recurrence rates of 25–70% (10–18). Podophyllin therapy is associated with local skin reactions, such as erythema, tenderness, pruitis, burning, edema, and pain (19), and since podophyllin is absorbed into the body, its use should be limited to small treatment areas (4–10 cm 2 ).…”

Section: External Genital Wartsmentioning

confidence: 99%

See 1 more Smart Citation

Therapy of external anogenital warts and molluscum contagiosum: a literature review

Ting

Dytoc

2004

Dermatol Ther

View full text Add to dashboard Cite

Anogenital warts and mollusca contagiosum are virally induced, benign skin tumors for which there is no single preferable therapy. Treatments include physical and chemical destruction, surgical removal, and biological response modifiers to enhance the natural immune response. The choice of therapy is an art, and depends upon patient preference, finances, number of lesions, and lesional morphology. However, the therapy of these lesions can sometimes be very painful and expensive, and therapy should not be worse than the disease.

show abstract

Section: External Genital Wartsmentioning

confidence: 99%

Section: External Genital Wartsmentioning

confidence: 99%

Therapy of external anogenital warts and molluscum contagiosum: a literature review

Ting

Dytoc

2004

Dermatol Ther

View full text Add to dashboard Cite

show abstract

“…Penile warts can be safely treated with 0.5-2.0% podophyllin self applied by the patient at a fraction of the cost of commercially available podophyllotoxin. The shelf life of podophyllin extract is at least 3 months, this is relevant for countries where resources for health care are limited (White et al, 1997). A mixture of natural and semisynthetic glycosides from Podophyllum hexandrum has been used for many years for the treatment of rheumatoid arthritis but it shows gastrointestinal side effects.…”

Section: Uses Of Podophyllotoxinmentioning

confidence: 99%

Untitled

2000

View full text Add to dashboard Cite

Podophyllum hexandrum Royle of family Berberidaceae is an endangered medicinal plant. Rhizome ofP.hexandrum contains several lignans which posses antitumor activity. Podphyllotoxin is the most active cytotoxic natural product. It is used as starting compound for the synthesis of anticancer drug etoposide and teniposide. Podophyllotoxin acts as an inhibitor of microtubule assembly. These drugs are used for lung cancer, testicular cancer, neuroblastoma, hepatoma and other tumors. Besides this, it also shows antiviral activities by interfering with some critical viral processes. Availabilityof podophyllotoxin from plants has its limitations because of its intense collection from nature and lack of organized cultivation. The chemical synthesis of podophyllotoxin is considered to be very complicated as yet. The use of biotechnological approaches for the production of podophyllotoxin using cell cultures, organ cultures, and biotransformation route or by manipulating biosynthetic pathway proves to be an attractive alternative for production of podophyllotoxin. The present paper discusses the current status of research, limitations and future prospects for theproduction of podophyllotoxinin vitro.

show abstract

“…It has been used in the treatment of genital infection to sterilize noncervical human papilloma virus [4]. Penile warts can be safely treated with 0.5–2.0% podophyllin self applied [5]. Goel et al .…”

Section: Introductionmentioning

confidence: 99%

Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome

Zhou

Yang

et al. 2012

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundPodophyllum hexandrum Royle (P. hexandrum) is a perennial herb and widely used in clinic. The present study was designed to separate and identify the biochemical composition and antioxidant capacity of extracts from P. hexandrum rhizome.MethodsThe ethyl acetate and ethanol extracts from P. hexandrum rhizome were analyzed by GC-MS (gas chromatography–mass spectrometry), and the antioxidant capacity of the extracts and the components was tested by using the DPPH (2, 2-diphenylpicrylhydrazyl) and FRAP (Ferric reducing/antioxidant power) assays.ResultsThe rhizome extracts had greater antioxidant capacity than the petiole extracts in DPPH and FRAP assays. About 16 kinds of main reactive oxygen components were identified in the extracts. Components of PADE (Phthalic acid, diisobutyl ester), BADE (1,2-Benzenedicarboxylic acid, diisooctyl ester), Polyneuridine, PODD (Podophyllotoxin, deoxy), β-Sitosterol and POD (Podophyllotoxin) showed the antioxidant capacity in some degree. PODD, POD, and Polyneuridine showed stronger antioxidant capacity with the IC50 and FRAP values of 9.61 ± 0.81 and 2923.98 ± 21.89 μM, 9.98 ± 0.24 and 2847.27 ± 14.82 μM, and 13.37 ± 0.35 and 2404.32 ± 36.88 μM, respectively, than the positive control ASA (Ascorbic acid) with the values of 60.78 ± 1.22 and 1267.5 ± 30.24 μM (P < 0.01).ConclusionsPODD, POD, and Polyneuridine are very critical for the antioxidant capacity in the extract of P. hexandrum rhizome. These results provide useful biochemical basis and information for the potential use of this plant.

show abstract

Podophyllin 0.5% or 2.0% v podophyllotoxin 0.5% for the self treatment of penile warts: a double blind randomised study.

Cited by 7 publications

References 4 publications

Therapy of external anogenital warts and molluscum contagiosum: a literature review

Therapy of external anogenital warts and molluscum contagiosum: a literature review

Untitled

Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome

Contact Info

Product

Resources

About