Podejrzenie nowotworu pęcherzykowego czy nowotwór pęcherzykowy? Dylemat patologa i chirurga

Abstract

Introduction: Cytological material obtained from Fine Needle Aspiration Biopsy (FNAB) does not permit us to distinguish between follicular carcinomas, adenomas, and hyperplastic nodules. The limitations of the method are: lack of possibility to assess the presence of tumour capsule, eventual capsular invasion, and angioinvasion. An unequivocal conclusion of whether what we have to deal with is a neoplastic or benign lesion is possible only after histopathological examination. The aim of the study was to confirm justification for using the term "Suspicious for Follicular Neoplasm" (SFN) in cytological diagnostics of thyroid carcinoma.

The predictive value of sonographic images of follicular lesions – a comparison with nodules unequivocal in FNA – single centre prospective study

“…In our centre, where cytological diagnostics is performed in the population which had been exposed to iodine deficiency until only 20 years ago [23], the risk of malignancy in FLUS nodules, as determined with the results of histopathological examination, does not exceed 6% [24, 25]. This risk is concordant with the assumptions made when the FLUS category was created and is significantly lower than that in SFN nodules, which show a 10-20% malignancy risk [25, 26]. …”

Rekomendacje Polskich Towarzystw Naukowych „Diagnostyka i leczenie raka tarczycy”. Aktualizacja na rok 2018

“…Cytological classification of lesions subjected to FNAB should be based on NCI guidelines, referred to the Bethesda System for Reporting Thyroid Cytopathology called "Bethesda Classification" in these "Recommendations" (Table II) [17,18] It is recommended that six classes of cytological diagnosis be used, according to the Bethesda Classification [18,20]. [25,26]. 14.4.1.…”

Transcriptional activity of TGFβ1 and its receptors genes in thyroid gland

“…On the one hand, thyroid nodules and lesions being one of the commonest clinical situations rarely prove to be malignant, and on the other hand the diagnostic accuracy of FNAB is limited. FNAB is a highly sensitive method in the differential diagnosis of thyroid nodules and lesions; however, a large percentage of thyroid FNABs give a considerable proportion of non-diagnostic results, so there is a need to find new tools for more precise preoperative assessment [32][33][34][35][36][37]. Patients would benefit from improved preoperative diagnosis, which could reduce the number or extent of surgeries, long-term health costs, and postsurgical complications.…”