PO22 Honey reduces chemoradiotherapy-induced mucositis in pediatric cancer patients

Jaouni, Soad Al; Hussein, Atif M.; Muhayawi, M. Al; Ibrahim, Karim; Elfiki, Inas

doi:10.1016/s1040-8428(12)70036-7

Cited by 2 publications

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“…Abdulrhman (1) found that in grade 2 and 3 mucositis, honey improved recovery time by nearly 2 days (6.10 versus 4.25 days) compared to standard care alone. Al Jaouni (14,15) found that children given regular honey had fever episodes of OM and that length of hospitalisation was shorter in the honey group (7 versus 13 days). Kobya Bulut (16) found an even more dramatic improvement in recovery time, although their baseline of 19 days seems unusually long.…”

Section: Commentarymentioning

confidence: 99%

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Global Health Journal Club: Is Honey Effective as a Treatment for Chemotherapy-induced Mucositis in Paediatric Oncology Patients?

Friend¹,

Rubagumya

Cartledge³

2017

Journal of Tropical Pediatrics

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Oral mucositis (OM) is an inflammatory response of mucosal epithelium to the cytotoxic effects of chemotherapy and radiotherapy causing severe oral pain and ulceration, which may complicate the management of cancer. The Mucositis Prevention Guideline Development Group has developed an international guideline for the prevention of mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation. Evidence-based preventative strategies include cryotherapy, low-level light therapy and keratinocyte growth factor. However, these strategies are often not available in resource-poor settings. There is some evidence that honey may be a suitable treatment for OM in adult patients. We performed a literature search of 11 databases to find papers exploring the use of honey to treat chemotherapy-associated mucositis in paediatric oncology patients. We found four papers, which provide Grade C evidence that honey is effective as a preventative and therapeutic measure for OM in paediatric oncology patients.

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Section: Commentarymentioning

confidence: 99%

“…PICO you note that Al Jaouni (14) reported the rate of candida and bacterial positive blood cultures reduced markedly in patients who were prophylactically given oral honey. However, the culture positive rates in the control group were alarmingly high and may question this result.…”

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confidence: 97%

Global Health Journal Club: Is Honey Effective as a Treatment for Chemotherapy-induced Mucositis in Paediatric Oncology Patients?

Friend¹,

Rubagumya

Cartledge³

2017

Journal of Tropical Pediatrics

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Antimicrobial Properties of Honey

Israili¹

2014

American Journal of Therapeutics

181

144

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Honey has been widely accepted as food and medicine by all generations, traditions, and civilizations, both ancient and modern. For at least 2700 years, honey has been used by humans to treat a variety of ailments through topical application, but only recently have the antiseptic and antimicrobial properties of honey been discovered. Honey has been reported to be effective in a number of human pathologies. Clinical studies have demonstrated that application of honey to severely infected cutaneous wounds rapidly clears infection from the wound and improves tissue healing. A large number of in vitro and limited clinical studies have confirmed the broad-spectrum antimicrobial (antibacterial, antifungal, antiviral, and antimycobacterial) properties of honey, which may be attributed to the acidity (low pH), osmotic effect, high sugar concentration, presence of bacteriostatic and bactericidal factors (hydrogen peroxide, antioxidants, lysozyme, polyphenols, phenolic acids, flavonoids, methylglyoxal, and bee peptides), and increase in cytokine release, and to immune modulating and anti-inflammatory properties of honey; the antimicrobial action involves several mechanisms. Despite a large amount of data confirming the antimicrobial activity of honey, there are no studies that support the systemic use of honey as an antibacterial agent.

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PO22 Honey reduces chemoradiotherapy-induced mucositis in pediatric cancer patients

Cited by 2 publications

References 0 publications

Global Health Journal Club: Is Honey Effective as a Treatment for Chemotherapy-induced Mucositis in Paediatric Oncology Patients?

Global Health Journal Club: Is Honey Effective as a Treatment for Chemotherapy-induced Mucositis in Paediatric Oncology Patients?

Antimicrobial Properties of Honey

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