Global Health Journal Club: Is Honey Effective as a Treatment for Chemotherapy-induced Mucositis in Paediatric Oncology Patients?

Friend, Amanda; Rubagumya, Fidel; Cartledge, Peter

doi:10.1093/tropej/fmx092

Cited by 20 publications

(13 citation statements)

References 14 publications

(7 reference statements)

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“…Friend et al specifically examined pediatric trials and identified 4 trials 62 , 71 , 77 , 79 with grade C evidence that honey was effective as a preventative and adjunctive therapy for chemotherapy-induced oral mucositis in children. 121 Honey was found to reduce the frequency, duration, and stage of chemotherapy-induced mucositis.…”

Section: Resultsmentioning

confidence: 99%

“…Recent interventions have continued to explore and to further build the scientific and clinical understanding of oral and intestinal mucositis preventative and treatment options that may be available to clinicians and patients. 13 , 112 , 121 , 133 The prevention and treatment of oral and intestinal mucositis that seeks to decrease the risk of formation and/or progression of these deleterious sequela of chemoradiotherapy regimens are important factors that impinge on patient quality of life and clinical decisions relevant to treatment. While it is acknowledged that oral and intestinal mucositis represent significant burdens of antineoplasitic therapies, the implementation of adjunctive treatments still remain a challenge.…”

Section: Discussionmentioning

confidence: 99%

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Adjunctive Treatments for the Prevention of Chemotherapy- and Radiotherapy-Induced Mucositis

2018

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Background: Chemoradiotherapy-associated mucositis can manifest as pain, inflammation, dysphagia, diarrhea, weight loss, rectal bleeding, and infection. Mucositis is a major dose-limiting side effect of chemotherapy, affecting nutritional intake and oral and intestinal function. Despite several interventions being available, there is a need for safe and effective preventative and treatment options for treatment-induced mucositis. The goals of this review are to discuss interventions based on foods and natural products and present the research to date. Methods: A narrative literature review identified 60 clinical studies examining various nutritional compounds and 20 examining probiotics. 9 studies on probiotics for the prevention of diarrhea were also assessed on methodological quality and limitations identified. Results: Several compounds have been posited as useful adjuvants for cancer treatment–related mucositis. Probiotics demonstrate efficacy for the prevention and treatment of chemoradiotherapy-induced gastrointestinal toxicity without significant side effects. Glutamine and activated charcoal were reported to reduce chemotherapy-induced diarrhea but not radiation-induced intestinal mucositis. Honey has been reported to decrease treatment interruptions, weight loss, and delays the onset of oral mucositis. Zinc, glutamine, and topical vitamin E were demonstrated efficacy for oral mucositis. Conclusion: There is plausible clinical evidence for the administration of several adjunctive treatments for the prevention and treatment of mucositis. Probiotics were reported to reduce the burden of intestinal mucositis and treatment-induced diarrhea. Activated charcoal and glutamine are beneficial for chemotherapy-induced diarrhea, whereas the administration of honey, zinc, and glutamine reduce the risk of developing oral mucositis during chemotherapy or radiotherapy.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Adjunctive Treatments for the Prevention of Chemotherapy- and Radiotherapy-Induced Mucositis

2018

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“…There is a systematic review on honey for the treatment of chemotherapy-induced mucositis in paediatric oncology patients [14]. It summarizes four papers on the topic and provides Grade C evidence that honey is effective as a preventative and therapeutic measure in paediatric oncology patients.…”

Section: Resultsmentioning

confidence: 99%

Using Bee Products for the Prevention and Treatment of Oral Mucositis Induced by Cancer Treatment

Münstedt

Männle

2019

Molecules

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Oral mucositis is one of the most frequent complications after chemotherapy or radiotherapy or a combination of both. There is no standard therapy for its prevention or treatment. Considering that some bee products have been found to be of value in this situation, we decided to analyze the scientific literature on the subject. Scientific publications on bee products were identified by a literature search on Pubmed, Scopus and Google Scholar. There is a lot of evidence regarding the use of honey for oral mucositis due to chemotherapy or radiotherapy or a combination of both. Unfortunately, the quality of several meta-analyses on the topic is very low. There is some evidence on propolis, a little on royal jelly and none whatsoever on pollen and other bee products like apilarnil or bee venom. Bee products such as honey, propolis and royal jelly may be well suited to be integrated into a general concept for the prevention and treatment of oral mucositis which should also include other established concepts like oral care, oral cryotherapy, topical vitamin E and low-level-laser therapy. Bee products could become an integral part in the treatment of chemotherapy, radiotherapy and radio chemotherapy. High-quality meta-analyses and further studies, especially on the combinations of various strategies, are needed.

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“…A meta-analysis indicates that honey can effectively reduce the incidence of chemotherapy and radiotherapy-induced oral mucositis (Xu et al, 2016 ). Further clinical evidence demonstrates its effectiveness as a preventative and therapeutic measure for chemotherapy-associated oral mucositis in pediatric oncology patients (Friend et al, 2018 ). There is potential interaction between oral microenvironment and mucositis development.…”

Section: Prevention Of Oral Mucositis Partly By Reducing Oxidative Stmentioning

confidence: 99%

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

et al. 2018

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Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy are the common cancer treatments. However, the development of adverse effects resulting from chemotherapy and radiotherapy hinders the clinical use, and negatively reduces the quality of life in cancer patients. Natural products including crude extracts, bioactive components-enriched fractions and pure compounds prepared from herbs as well as herbal formulas have been proved to prevent and treat cancer. Of significant interest, some natural products can reduce chemotherapy and radiotherapy-induced oral mucositis, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, hematopoietic system injury, cardiotoxicity, and neurotoxicity. This review focuses in detail on the effectiveness of these natural products, and describes the possible mechanisms of the actions in reducing chemotherapy and radiotherapy-induced side effects. Recent advances in the efficacy of natural dietary supplements to counteract these side effects are highlighted. In addition, we draw particular attention to gut microbiotan in the context of prebiotic potential of natural products for the protection against cancer therapy-induced toxicities. We conclude that some natural products are potential therapeutic perspective for the prevention and treatment of chemotherapy and radiotherapy-induced side effects. Further studies are required to validate the efficacy of natural products in cancer patients, and elucidate potential underlying mechanisms.

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Global Health Journal Club: Is Honey Effective as a Treatment for Chemotherapy-induced Mucositis in Paediatric Oncology Patients?

Cited by 20 publications

References 14 publications

Adjunctive Treatments for the Prevention of Chemotherapy- and Radiotherapy-Induced Mucositis

Adjunctive Treatments for the Prevention of Chemotherapy- and Radiotherapy-Induced Mucositis

Using Bee Products for the Prevention and Treatment of Oral Mucositis Induced by Cancer Treatment

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

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