Po11-302 Activity of Inflammatory-Destructive Changes During of Unstable Atherosclerotic Plaque Formation

Blood Levels of Inflammatory and Destructive Biomarkers in Coronary Atherosclerosis of Different Severity

“…The key role in destabilization of the atherosclerotic plaque is played by infl ammatory and destructive changes induced by activated monocytes/macrophages producing infl ammatory mediators and cytokines, including IL-1β, IL-6, IL-8, TNF-α, etc. [1,2,7,14,15]. Along with infl ammatory cytokines, activated macrophages produce destructive matrix metalloproteinases (MMP) inducing degradation of extracellular matrix of the plaque cap [2,5,7].…”

“…[1,2,7,14,15]. Along with infl ammatory cytokines, activated macrophages produce destructive matrix metalloproteinases (MMP) inducing degradation of extracellular matrix of the plaque cap [2,5,7]. These data were confi rmed by clinical studies detecting high levels of some infl ammatory-destructive biomarkers, in particular IL-6, highly-sensitive C-reactive protein (CRP), MMP-3, and MMP-9, in patients with ACS [3][4][5], therefore they are now considered by many authors as biomarkers of atherosclerotic plaque instability [2][3][4][5]10,11].…”