Pneumothorax in hospitalized COVID-19 patients with severe respiratory failure: Risk factors and outcome

Ragnoli, B.; Cena, Tiziana; Radaeli, A.; Pochetti, Patrizia; Conti, Lorenzo; Calareso, A.; Morjaria, J.; Malerba, Mario

doi:10.1016/j.rmed.2023.107194

Cited by 3 publications

(2 citation statements)

References 48 publications

(49 reference statements)

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“…This appears to be very important from a clinical point of view as recent data show that dementia can predict the severity of COVID-19 infection. In fact, patients with dementia are more exposed to the severe form of the infection and are more likely to require hospitalization and to have severe sequelae or fatal outcomes compared with patients who do not [5,121]. Finally, the racial variance of ACE I/D genotype polymorphism seems to be correlated with different outcomes during COVID-19 infection; in fact, populations with higher D allele frequency (e.g., Italian) experienced higher fatality [122].…”

Section: Coagulation Biomarkers In Sars-cov-2 Infection: a Predictive...mentioning

confidence: 99%

“…To date, there have been more than 762 million confirmed cases of COVID-19 infection, including almost 6.8 million deaths reported to WHO, while a total of 13,340,275,493 vaccine doses have been administered [2]. Among the wide range of SARS-CoV-2 clinical manifestations (cough, fever, pharyngodynia, myoarthralgia, fatigue), a respiratory tract involvement has been observed, potentially evolving with pneumonia, acute respiratory distress syndrome (ARDS), hyperinflammation, and COVID-19-associated-coagulopathy [3][4][5]. The hypercoagulable state is strongly associated with COVID-19 infection and may explain several phenomena observed in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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Interrelationship between COVID-19 and Coagulopathy: Pathophysiological and Clinical Evidence

Ragnoli

Galantino

et al. 2023

IJMS

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Since the first description of COVID-19 infection, among clinical manifestations of the disease, including fever, dyspnea, cough, and fatigue, it was observed a high incidence of thromboembolic events potentially evolving towards acute respiratory distress syndrome (ARDS) and COVID-19-associated-coagulopathy (CAC). The hypercoagulation state is based on an interaction between thrombosis and inflammation. The so-called CAC represents a key aspect in the genesis of organ damage from SARS-CoV-2. The prothrombotic status of COVID-19 can be explained by the increase in coagulation levels of D-dimer, lymphocytes, fibrinogen, interleukin 6 (IL-6), and prothrombin time. Several mechanisms have been hypothesized to explain this hypercoagulable process such as inflammatory cytokine storm, platelet activation, endothelial dysfunction, and stasis for a long time. The purpose of this narrative review is to provide an overview of the current knowledge on the pathogenic mechanisms of coagulopathy that may characterize COVID-19 infection and inform on new areas of research. New vascular therapeutic strategies are also reviewed.

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Section: Coagulation Biomarkers In Sars-cov-2 Infection: a Predictive...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interrelationship between COVID-19 and Coagulopathy: Pathophysiological and Clinical Evidence

Ragnoli

Galantino

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

Comparison of the risk of pneumothorax in COVID-19 and seasonal influenza

Song,

Kang,

Song

et al. 2024

Sci Rep

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Interrelationship between COVID-19 and coagulopathy: pathophysiological and clinical evidence

Ragnoli¹,

Re²,

Galantino³

et al. 2023

Preprint

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Since the first description of COVID-19 infection, among clinical manifestations of the disease including fever, dispnea, cough, fatigue, it was observed a high incidence of thromboembolic events potentially evolving towars ARDS and COVID-associated-coagulopathy (CAC).The hypercoagulation state is based on an interaction between thrombosis and inflammation. The so-called CAC represents a key aspect in the genesis of organ damage from SARS-CoV-2. The prothrombotic status in COVID-19 disease can be explained by the increase of coagulation levels of D-dimer, lymphocytes, fibrinogen, IL-6 and prothrombin time. Several mechanisms have been hypothesized to explain this hypercoagulable process such as inflammatory cytokine storm, platelet activation, endothelial dysfunction and stasis for a long time. The purpose of this narrative review is to provide an overview of the current knowledge on the pathogenic mechanisms of coagulopathy that may characterize COVID-19 infection and inform on new areas of research. New vascular therapeutic strategies are also reviewed.

show abstract

Pneumothorax in hospitalized COVID-19 patients with severe respiratory failure: Risk factors and outcome

Cited by 3 publications

References 48 publications

Interrelationship between COVID-19 and Coagulopathy: Pathophysiological and Clinical Evidence

Interrelationship between COVID-19 and Coagulopathy: Pathophysiological and Clinical Evidence

Comparison of the risk of pneumothorax in COVID-19 and seasonal influenza

Interrelationship between COVID-19 and coagulopathy: pathophysiological and clinical evidence

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