Pneumonic Plague: The Darker Side of Yersinia pestis

Pechous, Roger D.; Sivaraman, Vijay; Stasulli, Nikolas M.; Goldman, William E.

doi:10.1016/j.tim.2015.11.008

Cited by 131 publications

(141 citation statements)

References 56 publications

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“…Y. pestis is likely to have caused three major pandemics which led to significant loss of life. In the first in the 6th century AD it is thought that in some regions, between 50 and 60% of the population may have perished [41]. According to the WHO, currently there are high rates of plague in the Democratic Republic of Congo, Madagascar and Peru.…”

Section: Yersinia Pestismentioning

confidence: 99%

Pneumonia in the tropics: Report from the Task Force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine

Nor

Richards

McGloughlin

et al. 2017

Journal of Critical Care

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The aetiology of community acquired pneumonia varies according to the region in which it is acquired. This review discusses those causes of CAP that occur in the tropics and might not be readily recognizable when transplanted to other sites. Various forms of pneumonia including the viral causes such as influenza (seasonal and avian varieties), the coronaviruses and the Hantavirus as well as bacterial causes, specifically the pneumonic form of Yersinia pestis and melioidosis are discussed.

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Section: Yersinia Pestismentioning

confidence: 99%

Pneumonia in the tropics: Report from the Task Force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine

Nor

Richards

McGloughlin

et al. 2017

Journal of Critical Care

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“…It has a note worthy impact on the mortality rates, morbidity rates and the financial burden associated. Although various novel antibacterial drugs had been introduced into the market in the past decades, the prevalence of multidrug-resistant pathogens remains among the major health problems which raises severe concern around the globe (Bassetti et al, 2013;Butler et al, 2013;Kumarasamy et al, 2010;Lewis, 2013;Pendleton et al, 2013). Staphylococci and Enterococci are Gram-positive bacteria that are responsible for several community and hospital acquired infections.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, the gram-negative bacterium Yersinia pestis is the causative agent of pneumonic plague; which is the most severe manifestation of plague. The mortality rates of pneumonic plague are approximately 100% in untreated cases (Pechous et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antibacterial activity of novel 2-(arylimino)thiazolidin-4-one and 2-(benzylidenehydrazono)-3-arylthiazolidin-4-one derivatives

El‐Hossary¹,

Nissan²,

Edkins³

et al. 2016

J App Pharm Sci

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The ongoing spread of multidrug-resistant bacteria demands an intensive search for new antibacterial agents. In the present study, a series of new 1,3-thiazolidin-4-ones has been synthesized and investigated for its in vitro antibacterial activity. The most potent antibacterial compound 4c was found to be active, at low micromolar range, against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and the pneumonic plague causative agent Yersinia pestis with minimum inhibitory concentrations of 5 µM, 2.5 µM, 2.5 µM and 5 µM, respectively. Compound 4c showed the ability to kill E. faecalis JH212 strain with a minimum bactericidal concentration of 5 µM. Furthermore, compounds 9b and 10a inhibited the biofilm formation in S. epidermidis, where they showed 70% to 80% inhibition at a concentration of 40 µM.

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“…Y. pestis is transmitted through blood by fleas from its natural reservoirs, mainly rodents, squirrels, chipmunks or rabbits, and leads to the bubonic form of plague (Achtman et al 2004). The inhalation of the infectious respiratory droplets of bacteria Y. pestis results in the most severe primary pneumonic plague, with mortality rates approaching 100 percent in the absence of treatment (Pechous et al 2016). Both forms can lead to infection of the blood, causing bacteremia and septicemic plague.…”

Section: Introductionmentioning

confidence: 99%

“…The risk of utilizing of Yersinia by unauthorized groups as a biological weapon of terror (Pechous et al 2016; Hawley and Eitzen 2001), the climate change increasing the risk of plague outbreaks (Ben-Ari et al 2011), as well as the growing resistance of humans to antibiotics, are the reasons to search for new treatment options. The virulence factor YopH is a perfect candidate for a new drug target as it is essential for virulency of Yersinia bacteria (Bohmer et al 2012; Liang et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Aurintricarboxylic acid structure modifications lead to reduction of inhibitory properties against virulence factor YopH and higher cytotoxicity

Kuban–Jankowska

Sahu

Górska

et al. 2016

World J Microbiol Biotechnol

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Yersinia sp. bacteria owe their viability and pathogenic virulence to the YopH factor, which is a highly active bacterial protein tyrosine phosphatase. Inhibition of YopH phosphatase results in the lack of Yersinia sp. pathogenicity. We have previously described that aurintricarboxylic acid inhibits the activity of YopH at nanomolar concentrations and represents a unique mechanism of YopH inactivation due to a redox process. This work is a continuation of our previous studies. Here we show that modifications of the structure of aurintricarboxylic acid reduce the ability to inactivate YopH and lead to higher cytotoxicity. In the present paper we examine the inhibitory properties of aurintricarboxylic acid analogues, such as eriochrome cyanine R (ECR) and pararosaniline. Computational docking studies we report here indicate that ATA analogues are not precluded to bind in the YopH active site and in all obtained binding conformations ECR and pararosaniline bind to YopH active site. The free binding energy calculations show that ECR has a stronger binding affinity to YopH than pararosaniline, which was confirmed by experimental YopH enzymatic activity studies. We found that ATA analogues can reversibly reduce the enzymatic activity of YopH, but possess weaker inhibitory properties than ATA. The ATA analogues induced inactivation of YopH is probably due to oxidative mechanism, as pretreatment with catalase prevents from inhibition. We also found that ATA analogues significantly decrease the viability of macrophage cells, especially pararosaniline, while ATA reveals only slight effect on cell viability.

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Pneumonic Plague: The Darker Side of Yersinia pestis

Cited by 131 publications

References 56 publications

Pneumonia in the tropics: Report from the Task Force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine

Pneumonia in the tropics: Report from the Task Force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine

Synthesis and antibacterial activity of novel 2-(arylimino)thiazolidin-4-one and 2-(benzylidenehydrazono)-3-arylthiazolidin-4-one derivatives

Aurintricarboxylic acid structure modifications lead to reduction of inhibitory properties against virulence factor YopH and higher cytotoxicity

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